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Butyrate and Wnt signaling: a possible solution to the puzzle of dietary fiber and colon cancer risk?

Cell cycle (Georgetown, Tex.), 2008-05, Vol.7 (9), p.1178-1183

2008

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Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis

The Journal of clinical investigation, 2007-09, Vol.117 (9), p.2723-2734

2007

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ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux

JNCI : Journal of the National Cancer Institute, 2011-08, Vol.103 (16), p.1236-1251

2011

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Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors

Molecular cancer research, 2014-03, Vol.12 (3), p.381-393

2014

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Small-Molecule Multidrug Resistance―Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

Cancer research (Chicago, Ill.), 2009-08, Vol.69 (16), p.6573-6580

2009

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Disruption of cAMP and Prostaglandin E2 Transport by Multidrug Resistance Protein 4 Deficiency Alters cAMP-Mediated Signaling and Nociceptive Response

Molecular pharmacology, 2008-01, Vol.73 (1), p.243-251

2008

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Linear relationship between Wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate

International journal of cancer, 2004-07, Vol.110 (4), p.523-531

2004

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Stable Suppression of the R2 Subunit of Ribonucleotide Reductase by R2-targeted Short Interference RNA Sensitizes p53(–/–) HCT-116 Colon Cancer Cells to DNA-damaging Agents and Ribonucleotide Reductase Inhibitors

The Journal of biological chemistry, 2004-06, Vol.279 (26), p.27030-27038

2004

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Formation and Urinary Excretion of Arsenic Triglutathione and Methylarsenic Diglutathione

Chemical research in toxicology, 2004-02, Vol.17 (2), p.243-249

2004

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1,2-Bis(Methylsulfonyl)-1-(2-Chloroethyl)-2-[[1-(4-Nitrophenyl)Ethoxy]Carbonyl]Hydrazine: An Anticancer Agent Targeting Hypoxic Cells

Proceedings of the National Academy of Sciences - PNAS, 2005-06, Vol.102 (26), p.9282-9287

2005

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MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib

BMC cancer, 2016-07, Vol.16 (1), p.550-550, Article 550

2016

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Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine

Molecular cancer therapeutics, 2006-04, Vol.5 (4), p.969-976

2006

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Poly (ADP-ribose) polymerase inhibitors: on the horizon of tailored and personalized therapies for epithelial ovarian cancer

Current opinion in oncology, 2012-09, Vol.24 (5), p.564-571

2012

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Structure and Function Converge To Identify a Hydrogen Bond in a Group I Ribozyme Active Site

Angewandte Chemie (International ed.), 2009-01, Vol.48 (39), p.7171-7175

2009

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The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors

Experimental cell research, 2007-05, Vol.313 (8), p.1652-1666

2007

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4-Nitrobenzyloxycarbonyl Derivatives of O 6-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O 6-Alkylguanine-DNA Alkyltransferase (AGT), Which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine

Journal of medicinal chemistry, 2011-11, Vol.54 (21), p.7720-7728

2011

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Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair

British journal of cancer, 2016-03, Vol.114 (7), p.777-786

2016

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Comparison of DNA lesions produced by tumor-inhibitory 1,2-bis(sulfonyl)hydrazines and chloroethylnitrosoureas

Biochemical pharmacology, 2000-02, Vol.59 (3), p.283-291

2000

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Role of Tcf-DNA binding and the chromatin remodeling factor Brg-1 in the modulation of Wnt activity by butyrate

Cell cycle (Georgetown, Tex.), 2008-11, Vol.7 (21), p.3472-3473

2008

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Hypoxia-Selective O 6‑Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis, and Evaluation of 6‑(Benzyloxy)-2-(aryldiazenyl)‑9H‑purines as Prodrugs of O 6‑Benzylguanine

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.1355-1359

2013

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Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes

Biochemical pharmacology, 2014-10, Vol.91 (3), p.312-322

2014

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4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine

Journal of medicinal chemistry, 2011-11, Vol.54 (21), p.7720

2011

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Antitumor Sulfonylhydrazines: Design, Structure–Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.3639-3671

2015

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The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph Nodes

Cell, 2000-11, Vol.103 (5), p.757-768

2000

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Interim results of a randomized trial of mitomycin C as an adjunct to radical radiotherapy in the treatment of locally advanced squamous‐cell carcinoma of the cervix

International journal of cancer, 2000-08, Vol.90 (4), p.206-223

2000

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Butyrate and Wnt signaling: a possible solution to the puzzle of dietary fiber and colon cancer risk?

Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis

ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux

Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors

Small-Molecule Multidrug Resistance―Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

Disruption of cAMP and Prostaglandin E2 Transport by Multidrug Resistance Protein 4 Deficiency Alters cAMP-Mediated Signaling and Nociceptive Response

Linear relationship between Wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate

Stable Suppression of the R2 Subunit of Ribonucleotide Reductase by R2-targeted Short Interference RNA Sensitizes p53(–/–) HCT-116 Colon Cancer Cells to DNA-damaging Agents and Ribonucleotide Reductase Inhibitors

Formation and Urinary Excretion of Arsenic Triglutathione and Methylarsenic Diglutathione

1,2-Bis(Methylsulfonyl)-1-(2-Chloroethyl)-2-[[1-(4-Nitrophenyl)Ethoxy]Carbonyl]Hydrazine: An Anticancer Agent Targeting Hypoxic Cells

MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib

Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine

Poly (ADP-ribose) polymerase inhibitors: on the horizon of tailored and personalized therapies for epithelial ovarian cancer

Structure and Function Converge To Identify a Hydrogen Bond in a Group I Ribozyme Active Site

The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors

4-Nitrobenzyloxycarbonyl Derivatives of O 6-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O 6-Alkylguanine-DNA Alkyltransferase (AGT), Which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine

Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair

Comparison of DNA lesions produced by tumor-inhibitory 1,2-bis(sulfonyl)hydrazines and chloroethylnitrosoureas

Role of Tcf-DNA binding and the chromatin remodeling factor Brg-1 in the modulation of Wnt activity by butyrate

Hypoxia-Selective O 6‑Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis, and Evaluation of 6‑(Benzyloxy)-2-(aryldiazenyl)‑9H‑purines as Prodrugs of O 6‑Benzylguanine

Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes

4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine

Antitumor Sulfonylhydrazines: Design, Structure–Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility

The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph Nodes

Interim results of a randomized trial of mitomycin C as an adjunct to radical radiotherapy in the treatment of locally advanced squamous‐cell carcinoma of the cervix

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