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Investigational IGF1R inhibitors in early stage clinical trials for cancer therapy

Expert opinion on investigational drugs, 2019-12, Vol.28 (12), p.1101-1112

2019

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Minireview: Nuclear Insulin and Insulin-like Growth Factor-1 Receptors: A Novel Paradigm in Signal Transduction

Endocrinology (Philadelphia), 2013-05, Vol.154 (5), p.1672-1679

2013

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Nuclear insulin-like growth factor-1 receptor (IGF1R) displays proliferative and regulatory activities in non-malignant cells

PloS one, 2017-09, Vol.12 (9), p.e0185164-e0185164

2017

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Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners

PloS one, 2013-04, Vol.8 (4), p.e61537

2013

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Transcriptional and epigenetic control of IGF1R gene expression: Implications in metabolism and cancer

Growth hormone & IGF research, 2014-08, Vol.24 (4), p.112-118

2014

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The Role of Nuclear Insulin and IGF1 Receptors in Metabolism and Cancer

Biomolecules (Basel, Switzerland), 2021-04, Vol.11 (4), p.531

2021

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Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action

Proceedings of the National Academy of Sciences - PNAS, 2018-01, Vol.115 (5), p.1045-1050

2018

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Laron Syndrome Research Paves the Way for New Insights in Oncological Investigation

Cells (Basel, Switzerland), 2020-11, Vol.9 (11), p.2446

2020

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Differential Effects of Insulin and IGF1 Receptors on ERK and AKT Subcellular Distribution in Breast Cancer Cells

Cells (Basel, Switzerland), 2019-11, Vol.8 (12), p.1499

2019

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Long-Term IGF1 Stimulation Leads to Cellular Senescence via Functional Interaction with the Thioredoxin-Interacting Protein, TXNIP

Cells (Basel, Switzerland), 2022-10, Vol.11 (20), p.3260

2022

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MicroRNA 132-3p Is Upregulated in Laron Syndrome Patients and Controls Longevity Gene Expression

International journal of molecular sciences, 2021-11, Vol.22 (21), p.11861

2021

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The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway

PloS one, 2011-09, Vol.6 (9), p.e24468-e24468

2011

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Insulin-like Growth Factor-I Receptor (IGF-IR) Translocates to Nucleus and Autoregulates IGF-IR Gene Expression in Breast Cancer Cells

The Journal of biological chemistry, 2012-01, Vol.287 (4), p.2766-2776

2012

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Systems Analysis of Insulin and IGF1 Receptors Networks in Breast Cancer Cells Identifies Commonalities and Divergences in Expression Patterns

Frontiers in endocrinology (Lausanne), 2020-07, Vol.11, p.435-435

2020

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The intricate involvement of the Insulin-like growth factor receptor signaling in mild traumatic brain injury in mice

Neurobiology of disease, 2010-05, Vol.38 (2), p.299-303

2010

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The Olfactory Receptor Gene Product, OR5H2, Modulates Endometrial Cancer Cells Proliferation via Interaction with the IGF1 Signaling Pathway

Cells (Basel, Switzerland), 2021-06, Vol.10 (6), p.1483

2021

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Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action

Cells (Basel, Switzerland), 2022-05, Vol.11 (10), p.1627

2022

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Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways

Cells (Basel, Switzerland), 2019-06, Vol.8 (6), p.596

2019

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p53 Regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy

European journal of cancer (1990), 2012-07, Vol.48 (10), p.1570-1580

2012

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Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer

Oncotarget, 2019-07, Vol.10 (43), p.4437-4448

2019

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ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease

Frontiers in endocrinology (Lausanne), 2021-06, Vol.12, p.688104

2021

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Genome-Wide Analyses Identify Filamin-A As a Novel Downstream Target for Insulin and IGF1 Action

Frontiers in endocrinology (Lausanne), 2018-03, Vol.9, p.105-105

2018

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IGF1R-directed targeted therapy enhances the cytotoxic effect of chemotherapy in endometrial cancer

Cancer letters, 2013-07, Vol.335 (1), p.153-159

2013

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Tumor suppressor p53 regulates insulin receptor ( INSR ) gene expression via direct binding to the INSR promoter

Oncotarget, 2020-06, Vol.11 (25), p.2424-2437

2020

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The WT1 Wilms' tumor suppressor gene is a downstream target for insulin‐like growth factor‐I (IGF‐I) action in PC12 cells

Journal of neurochemistry, 2006-11, Vol.99 (3), p.818-826

2006

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Investigational IGF1R inhibitors in early stage clinical trials for cancer therapy

Minireview: Nuclear Insulin and Insulin-like Growth Factor-1 Receptors: A Novel Paradigm in Signal Transduction

Nuclear insulin-like growth factor-1 receptor (IGF1R) displays proliferative and regulatory activities in non-malignant cells

Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners

Transcriptional and epigenetic control of IGF1R gene expression: Implications in metabolism and cancer

The Role of Nuclear Insulin and IGF1 Receptors in Metabolism and Cancer

Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action

Laron Syndrome Research Paves the Way for New Insights in Oncological Investigation

Differential Effects of Insulin and IGF1 Receptors on ERK and AKT Subcellular Distribution in Breast Cancer Cells

Long-Term IGF1 Stimulation Leads to Cellular Senescence via Functional Interaction with the Thioredoxin-Interacting Protein, TXNIP

MicroRNA 132-3p Is Upregulated in Laron Syndrome Patients and Controls Longevity Gene Expression

The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway

Insulin-like Growth Factor-I Receptor (IGF-IR) Translocates to Nucleus and Autoregulates IGF-IR Gene Expression in Breast Cancer Cells

Systems Analysis of Insulin and IGF1 Receptors Networks in Breast Cancer Cells Identifies Commonalities and Divergences in Expression Patterns

The intricate involvement of the Insulin-like growth factor receptor signaling in mild traumatic brain injury in mice

The Olfactory Receptor Gene Product, OR5H2, Modulates Endometrial Cancer Cells Proliferation via Interaction with the IGF1 Signaling Pathway

Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action

Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways

p53 Regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy

Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer

ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease

Genome-Wide Analyses Identify Filamin-A As a Novel Downstream Target for Insulin and IGF1 Action

IGF1R-directed targeted therapy enhances the cytotoxic effect of chemotherapy in endometrial cancer

Tumor suppressor p53 regulates insulin receptor ( INSR ) gene expression via direct binding to the INSR promoter

The WT1 Wilms' tumor suppressor gene is a downstream target for insulin‐like growth factor‐I (IGF‐I) action in PC12 cells

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