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Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

Science (American Association for the Advancement of Science), 2005-02, Vol.307 (5712), p.1098-1101

2005

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Current biology, 2004-07, Vol.14 (14), p.1296-1302

2004

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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Molecular cell, 2006-04, Vol.22 (2), p.159-168

2006

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FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K-AKT Pathway

Cancer research (Chicago, Ill.), 2014-03, Vol.74 (6), p.1682-1693

2014

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Growing roles for the mTOR pathway

Current opinion in cell biology, 2005-12, Vol.17 (6), p.596-603

2005

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Redox Regulation of the Nutrient-sensitive Raptor-mTOR Pathway and Complex

The Journal of biological chemistry, 2005-11, Vol.280 (47), p.39505-39509

2005

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Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1

Molecular cell, 2015-06, Vol.58 (6), p.989-1000

2015

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ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies

Science signaling, 2016-02, Vol.9 (415), p.ra17

2016

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Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis

Breast cancer research : BCR, 2017-06, Vol.19 (1), p.74-74, Article 74

2017

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Rictor regulates cell migration by suppressing RhoGDI2

Oncogene, 2013-05, Vol.32 (20), p.2521-2526

2013

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The Vitamin C Enantiomers Possess a Comparable Potency in the Induction of Oxidative Stress in Cancer Cells but Differ in Their Toxicity

International journal of molecular sciences, 2024-02, Vol.25 (5), p.2531

2024

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Cell, 2002-07, Vol.110 (2), p.163-175

2002

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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML

Blood, 2007-04, Vol.109 (8), p.3509-3512

2007

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Formation of mammalian preribosomes proceeds from intermediate to composed state during ribosome maturation

The Journal of biological chemistry, 2019-07, Vol.294 (28), p.10746-10757

2019

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GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

Molecular cell, 2003-04, Vol.11 (4), p.895-904

2003

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Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation

Oncogene, 2009-07, Vol.28 (26), p.2436-2445

2009

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Enhancing an Oxidative "Trojan Horse" Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside

Cells (Basel, Switzerland), 2022-11, Vol.11 (21), p.3454

2022

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Autoregulation of the Mechanistic Target of Rapamycin (mTOR) Complex 2 Integrity Is Controlled by an ATP-dependent Mechanism

The Journal of biological chemistry, 2013-09, Vol.288 (38), p.27019-27030

2013

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High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia

Haematologica (Roma), 2017-09, Vol.102 (9), p.1537

2017

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Integrity of mTORC2 is dependent on the rictor Gly-934 site

Oncogene, 2012-04, Vol.31 (16), p.2115-2120

2012

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Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers

Cancer research (Chicago, Ill.), 2016-08, Vol.76 (16), p.4752-4764

2016

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Isolation of the mTOR complexes by affinity purification

Methods in molecular biology (Clifton, N.J.), 2012-01, Vol.821, p.59

2012

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Endoplasmic reticulum is a main localization site of mTORC2

Biochemical and biophysical research communications, 2011-09, Vol.413 (1), p.46-52

2011

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The mTOR (Mammalian Target of Rapamycin) Kinase Maintains Integrity of mTOR Complex 2

The Journal of biological chemistry, 2011-11, Vol.286 (46), p.40386-40394

2011

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A chirality‐dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics

International journal of cancer, 2020-05, Vol.146 (10), p.2822-2828

2020

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Proto-Oncogene Proteins C-Akt - Metabolism
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Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K-AKT Pathway

Growing roles for the mTOR pathway

Redox Regulation of the Nutrient-sensitive Raptor-mTOR Pathway and Complex

Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1

ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies

Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis

Rictor regulates cell migration by suppressing RhoGDI2

The Vitamin C Enantiomers Possess a Comparable Potency in the Induction of Oxidative Stress in Cancer Cells but Differ in Their Toxicity

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML

Formation of mammalian preribosomes proceeds from intermediate to composed state during ribosome maturation

GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation

Enhancing an Oxidative "Trojan Horse" Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside

Autoregulation of the Mechanistic Target of Rapamycin (mTOR) Complex 2 Integrity Is Controlled by an ATP-dependent Mechanism

High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia

Integrity of mTORC2 is dependent on the rictor Gly-934 site

Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers

Isolation of the mTOR complexes by affinity purification

Endoplasmic reticulum is a main localization site of mTORC2

The mTOR (Mammalian Target of Rapamycin) Kinase Maintains Integrity of mTOR Complex 2

A chirality‐dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics

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