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Inhibition of CD45 Phosphatase Activity Induces Cell Cycle Arrest and Apoptosis of CD45 + Lymphoid Tumors Ex Vivo and In Vivo

Molecular pharmacology, 2018-06, Vol.93 (6), p.575-580

2018

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BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss

PloS one, 2019-10, Vol.14 (10), p.e0224022-e0224022

2019

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Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm

Neurobiology of disease, 2017-01, Vol.97 (Pt B), p.139-155

2017

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Modulation of diabetic kidney disease markers by an antagonist of p75NTR in streptozotocin-treated mice

Gene, 2022-09, Vol.838, p.146729-146729, Article 146729

2022

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UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans

Scientific reports, 2018-05, Vol.8 (1), p.6860-15, Article 6860

2018

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An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma

Investigative ophthalmology & visual science, 2010-09, Vol.51 (9), p.4722-4731

2010

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The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy

PloS one, 2018-06, Vol.13 (6), p.e0199079-e0199079

2018

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Antagonism of proNGF or its receptor p75NTR reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction

Diabetologia, 2020-09, Vol.63 (9), p.1932-1946

2020

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Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy

Frontiers in immunology, 2020-09, Vol.11, p.564499-564499

2020

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Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology

PloS one, 2015-08, Vol.10 (8), p.e0134255-e0134255

2015

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Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation

PloS one, 2019-06, Vol.14 (6), p.e0218036-e0218036

2019

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Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo

Molecular pharmacology, 2014-04, Vol.85 (4), p.553-563

2014

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Neuronal injury external to the retina rapidly activates retinal glia, followed by elevation of markers for cell cycle re-entry and death in retinal ganglion cells

PloS one, 2014-07, Vol.9 (7), p.e101349-e101349

2014

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Effective chimeric antigen receptor T cells against SARS-CoV-2

iScience, 2021-11, Vol.24 (11), p.103295-103295, Article 103295

2021

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GD2 and GD3 gangliosides as diagnostic biomarkers for all stages and subtypes of epithelial ovarian cancer

Frontiers in oncology, 2023-04, Vol.13, p.1134763-1134763

2023

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Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors

PloS one, 2014-03, Vol.9 (3), p.e89617

2014

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The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS

PloS one, 2016-10, Vol.11 (10), p.e0162307

2016

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In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death

Investigative ophthalmology & visual science, 2010-12, Vol.51 (12), p.6639-6651

2010

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Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors

The Journal of biological chemistry, 2020-05, Vol.295 (19), p.6532-6542

2020

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Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies

Brain (London, England : 1878), 2022-08, Vol.145 (8), p.2806-2822

2022

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A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α2-Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to Neurodegeneration Ex Vivo and In Vivo

Molecular and cellular biology, 2015-10, Vol.35 (19), p.3396-3408

2015

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Differential roles of Trk and p75 neurotrophin receptors in tumorigenesis and chemoresistance ex vivo and in vivo

Cancer chemotherapy and pharmacology, 2010-05, Vol.65 (6), p.1047-1056

2010

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Prodrug chemotherapeutics bypass p-glycoprotein resistance and kill tumors in vivo with high efficacy and target-dependent selectivity

Oncogene, 2004-04, Vol.23 (20), p.3613-3621

2004

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kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin

The Journal of cell biology, 2006-04, Vol.173 (2), p.291-299

2006

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Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands

iScience, 2020-09, Vol.23 (9), p.101447-101447, Article 101447

2020

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Inhibition of CD45 Phosphatase Activity Induces Cell Cycle Arrest and Apoptosis of CD45 + Lymphoid Tumors Ex Vivo and In Vivo

BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss

Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm

Modulation of diabetic kidney disease markers by an antagonist of p75NTR in streptozotocin-treated mice

UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans

An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma

The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy

Antagonism of proNGF or its receptor p75NTR reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction

Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy

Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation

Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo

Neuronal injury external to the retina rapidly activates retinal glia, followed by elevation of markers for cell cycle re-entry and death in retinal ganglion cells

Effective chimeric antigen receptor T cells against SARS-CoV-2

GD2 and GD3 gangliosides as diagnostic biomarkers for all stages and subtypes of epithelial ovarian cancer

Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors

The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS

In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death

Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies

A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α2-Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to Neurodegeneration Ex Vivo and In Vivo

Differential roles of Trk and p75 neurotrophin receptors in tumorigenesis and chemoresistance ex vivo and in vivo

Prodrug chemotherapeutics bypass p-glycoprotein resistance and kill tumors in vivo with high efficacy and target-dependent selectivity

kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin

Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands

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