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BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss

PloS one, 2019-10, Vol.14 (10), p.e0224022-e0224022

2019

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Inhibition of CD45 Phosphatase Activity Induces Cell Cycle Arrest and Apoptosis of CD45 + Lymphoid Tumors Ex Vivo and In Vivo

Molecular pharmacology, 2018-06, Vol.93 (6), p.575-580

2018

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Alpha-2-macroglobulin prevents platelet aggregation induced by brain-derived neurotrophic factor

Biochemical pharmacology, 2023-09, Vol.215, p.115701-115701, Article 115701

2023

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Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm

Neurobiology of disease, 2017-01, Vol.97 (Pt B), p.139-155

2017

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Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies

Brain (London, England : 1878), 2022-08, Vol.145 (8), p.2806-2822

2022

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Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors

The Journal of biological chemistry, 2020-05, Vol.295 (19), p.6532-6542

2020

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Modulation of diabetic kidney disease markers by an antagonist of p75NTR in streptozotocin-treated mice

Gene, 2022-09, Vol.838, p.146729-146729, Article 146729

2022

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A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α2-Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to Neurodegeneration Ex Vivo and In Vivo

Molecular and cellular biology, 2015-10, Vol.35 (19), p.3396-3408

2015

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UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans

Scientific reports, 2018-05, Vol.8 (1), p.6860-15, Article 6860

2018

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Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology

PloS one, 2015-08, Vol.10 (8), p.e0134255-e0134255

2015

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Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation

PloS one, 2019-06, Vol.14 (6), p.e0218036-e0218036

2019

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Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy

Frontiers in immunology, 2020-09, Vol.11, p.564499-564499

2020

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Antagonism of proNGF or its receptor p75NTR reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction

Diabetologia, 2020-09, Vol.63 (9), p.1932-1946

2020

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An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma

Investigative ophthalmology & visual science, 2010-09, Vol.51 (9), p.4722-4731

2010

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The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy

PloS one, 2018-06, Vol.13 (6), p.e0199079-e0199079

2018

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Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses

The Journal of clinical investigation, 2021-04, Vol.131 (8), p.1-18

2021

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Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor

Molecular pharmacology, 2021-11, Vol.100 (5), p.491-501

2021

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Neuronal injury external to the retina rapidly activates retinal glia, followed by elevation of markers for cell cycle re-entry and death in retinal ganglion cells

PloS one, 2014-07, Vol.9 (7), p.e101349-e101349

2014

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p75NTR and Its Ligand ProNGF Activate Paracrine Mechanisms Etiological to the Vascular, Inflammatory, and Neurodegenerative Pathologies of Diabetic Retinopathy

The Journal of neuroscience, 2016-08, Vol.36 (34), p.8826-8841

2016

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Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors

PloS one, 2014-03, Vol.9 (3), p.e89617

2014

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Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo

Molecular pharmacology, 2014-04, Vol.85 (4), p.553-563

2014

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The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS

PloS one, 2016-10, Vol.11 (10), p.e0162307

2016

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A neurotrophic rationale for the therapy of neurodegenerative disorders

Current Alzheimer research, 2009-10, Vol.6 (5), p.419-423

2009

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Vaccination with Tumor-Ganglioside Glycomimetics Activates a Selective Immunity that Affords Cancer Therapy

Cell chemical biology, 2019-07, Vol.26 (7), p.1013-1026.e4

2019

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Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease

Science advances, 2020-01, Vol.6 (4), p.eaax6646-eaax6646

2020

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BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss

Inhibition of CD45 Phosphatase Activity Induces Cell Cycle Arrest and Apoptosis of CD45 + Lymphoid Tumors Ex Vivo and In Vivo

Alpha-2-macroglobulin prevents platelet aggregation induced by brain-derived neurotrophic factor

Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies

Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors

Modulation of diabetic kidney disease markers by an antagonist of p75NTR in streptozotocin-treated mice

A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α2-Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to Neurodegeneration Ex Vivo and In Vivo

UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans

Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation

Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy

Antagonism of proNGF or its receptor p75NTR reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction

An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma

The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy

Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses

Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor

Neuronal injury external to the retina rapidly activates retinal glia, followed by elevation of markers for cell cycle re-entry and death in retinal ganglion cells

p75NTR and Its Ligand ProNGF Activate Paracrine Mechanisms Etiological to the Vascular, Inflammatory, and Neurodegenerative Pathologies of Diabetic Retinopathy

Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors

Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo

The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS

A neurotrophic rationale for the therapy of neurodegenerative disorders

Vaccination with Tumor-Ganglioside Glycomimetics Activates a Selective Immunity that Affords Cancer Therapy

Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease

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