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Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity

Current medicinal chemistry, 2021-01, Vol.28 (35), p.7247-7277

2021

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Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents

European journal of medicinal chemistry, 2015-07, Vol.100, p.257-269

2015

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Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-based Scaffolds en Route to Donepezil-Like Compounds

Molecules (Basel, Switzerland), 2020-01, Vol.25 (3), p.574

2020

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A novel organic semiconductor 4-phenylthiazol-2-yl-(phenylhydrazono) acetonitrile (PTPA) thin films: synthesis, optical and electrical properties

Scientific reports, 2023-08, Vol.13 (1), p.12973-12973, Article 12973

2023

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Hydroxypyridinone-Based Metal Chelators towards Ecotoxicity: Remediation and Biological Mechanisms

Molecules (Basel, Switzerland), 2022-03, Vol.27 (6), p.1966

2022

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New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease

Molecules (Basel, Switzerland), 2019-02, Vol.24 (3), p.587

2019

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Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy

Future medicinal chemistry, 2016-11, Vol.8 (17), p.2113-2142

2016

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Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies

Journal of medicinal chemistry, 2018-05, Vol.61 (10), p.4421-4435

2018

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Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

Molecules (Basel, Switzerland), 2020-02, Vol.25 (4), p.985

2020

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Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's Disease

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.211-226

2020

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Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates

Journal of enzyme inhibition and medicinal chemistry, 2018-01, Vol.33 (1), p.1212-1224

2018

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Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease

European journal of medicinal chemistry, 2018-03, Vol.148 (C), p.255-267

2018

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Exploring the chelating capacity of 2-hydroxyphenyl-benzimidazole based hybrids with multi-target ability as anti-Alzheimer's agents

New journal of chemistry, 2018-10, Vol.42 (2), p.1653-16515

2018

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A Multi-Technique Investigation of the Complex Formation Equilibria between Bis-Deferiprone Derivatives and Oxidovanadium (IV)

Molecules (Basel, Switzerland), 2022-02, Vol.27 (5), p.1555

2022

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Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease

European journal of medicinal chemistry, 2022-07, Vol.237, p.114358-114358, Article 114358

2022

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Multifunctional Small Molecules as Potential Anti-Alzheimer's Disease Agents

Molecules (Basel, Switzerland), 2021-10, Vol.26 (19), p.6015

2021

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Rivastigmine-Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases

International journal of molecular sciences, 2023-05, Vol.24 (9), p.8312

2023

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Novel Donepezil-Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer's Disease

Molecules (Basel, Switzerland), 2021-03, Vol.26 (6), p.1658

2021

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Exploiting the potential of rivastigmine-melatonin derivatives as multitarget metal-modulating drugs for neurodegenerative diseases

Journal of inorganic biochemistry, 2025-01, Vol.262, p.112734, Article 112734

2025

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Speciation Studies of Bifunctional 3-Hydroxy-4-Pyridinone Ligands in the Presence of Zn2+ at Different Ionic Strengths and Temperatures

Molecules (Basel, Switzerland), 2019-11, Vol.24 (22), p.4084

2019

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Design, synthesis and neuroprotective evaluation of novel tacrine–benzothiazole hybrids as multi-targeted compounds against Alzheimer’s disease

Bioorganic & medicinal chemistry, 2013-08, Vol.21 (15), p.4559-4569

2013

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Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer's agents: AChE inhibition, antioxidant activity and metal chelating capacity

Journal of inorganic biochemistry, 2016-10, Vol.163, p.266-277

2016

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Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization

Journal of inorganic biochemistry, 2020-05, Vol.206, p.111039-111039, Article 111039

2020

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New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation

Dalton transactions : an international journal of inorganic chemistry, 2019-11, Vol.48 (43), p.16167-16183

2019

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Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug

Metallomics, 2018-10, Vol.10 (10), p.1460-1475

2018

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Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity

Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents

Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-based Scaffolds en Route to Donepezil-Like Compounds

A novel organic semiconductor 4-phenylthiazol-2-yl-(phenylhydrazono) acetonitrile (PTPA) thin films: synthesis, optical and electrical properties

Hydroxypyridinone-Based Metal Chelators towards Ecotoxicity: Remediation and Biological Mechanisms

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease

Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy

Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's Disease

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease

Exploring the chelating capacity of 2-hydroxyphenyl-benzimidazole based hybrids with multi-target ability as anti-Alzheimer's agents

A Multi-Technique Investigation of the Complex Formation Equilibria between Bis-Deferiprone Derivatives and Oxidovanadium (IV)

Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease

Multifunctional Small Molecules as Potential Anti-Alzheimer's Disease Agents

Rivastigmine-Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases

Novel Donepezil-Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer's Disease

Exploiting the potential of rivastigmine-melatonin derivatives as multitarget metal-modulating drugs for neurodegenerative diseases

Speciation Studies of Bifunctional 3-Hydroxy-4-Pyridinone Ligands in the Presence of Zn2+ at Different Ionic Strengths and Temperatures

Design, synthesis and neuroprotective evaluation of novel tacrine–benzothiazole hybrids as multi-targeted compounds against Alzheimer’s disease

Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer's agents: AChE inhibition, antioxidant activity and metal chelating capacity

Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization

New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation

Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug

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