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Dysregulation of RNA polymerase I transcription during disease

Biochimica et biophysica acta, 2013-03, Vol.1829 (3-4), p.342-360

2013

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A novel role for Top2α as a mediator of resistance to ribosomal DNA transcription inhibition

European journal of cancer (1990), 2016-07, Vol.61, p.S134-S135

2016

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513 A Fra-1-regulated Gene Expression Network Required for Maintenance of Epithelial-mesenchymal Transition in Human Colon Cancer Cells

European journal of cancer (1990), 2012-07, Vol.48, p.S122-S122

2012

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First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Cancer discovery, 2019-08, Vol.9 (8), p.1036-1049

2019

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ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway

Human molecular genetics, 2003-02, Vol.12 (3), p.247-255

2003

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Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

The EMBO journal, 2020-11, Vol.39 (21), p.e105111-n/a

2020

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Ets-2 Is Induced by Oxidative Stress and Sensitizes Cells to H2O2-Induced Apoptosis: Implications for Down's Syndrome

Biochemical and biophysical research communications, 2001-10, Vol.287 (4), p.1003-1008

2001

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606 - A novel role for Top2α as a mediator of resistance to ribosomal DNA transcription inhibition

European journal of cancer (1990), 2016-07, Vol.61, p.S134-S135

2016

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Characterization and transcriptional analysis of the mouse Chromosome 16 cytokine receptor gene cluster

Mammalian genome, 2003-02, Vol.14 (2), p.105-118

2003

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Transformation induced by Ewing's sarcoma associated EWS FLI-1 is suppressed by KRAB FLI-1

British journal of cancer, 2003-01, Vol.88 (1), p.137-145

2003

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Ets-2 Is Induced by Oxidative Stress and Sensitizes Cells to H2O2-Induced Apoptosis: Implications for Down's Syndrome

Biochemical and biophysical research communications, 2002-02, Vol.291 (1), p.191

2002

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Ets-2 Is Induced by Oxidative Stress and Sensitizes Cells to H2O2-Induced Apoptosis: Implications for Down's Syndrome: Volume 287, Number 4 (2001), pages 1003–1008

Biochemical and biophysical research communications, 2002-02, Vol.291 (1), p.191-191

2002

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Epstein-Barr virus LMP1 blocks p16 super(INK4a)-RB pathway by promoting nuclear export of E2F4/5

The Journal of cell biology, 2003-07, Vol.162 (2), p.173-183

2003

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Ets-2 is induced by oxidative stress and sensitizes cells to H(2)O(2)-induced apoptosis: implications for Down's syndrome

Biochemical and biophysical research communications, 2001-10, Vol.287 (4), p.1003

2001

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Ets-2 Is Induced by Oxidative Stress and Sensitizes Cells to H sub(2)O sub(2)-Induced Apoptosis: Implications for Down's Syndrome

Biochemical and biophysical research communications, 2001-10, Vol.287 (4), p.1003-1008

2001

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Characterization of monoclonal antibodies specific to the transcription factor ETS-2 protein

Immunology letters, 2003-03, Vol.86 (1), p.63-70

2003

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Study of energy storage systems and environmental challenges of batteries

Renewable & sustainable energy reviews, 2019-04, Vol.104, p.192-208

2019

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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Nature communications, 2020-05, Vol.11 (1), p.2641-18, Article 2641

2020

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Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (36), p.17990-18000

2019

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The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

British journal of cancer, 2021-02, Vol.124 (3), p.616-627

2021

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Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Oncotarget, 2016-08, Vol.7 (31), p.49800-49818

2016

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Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

Cancer research (Chicago, Ill.), 2011-02, Vol.71 (4), p.1418-1430

2011

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Canada’s Geothermal Energy Update in 2023

Energies (Basel), 2024-04, Vol.17 (8), p.1807

2024

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Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses

mBio, 2017-10, Vol.8 (5)

2017

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Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance

International journal of cancer, 2018-05, Vol.142 (10), p.2139-2152

2018

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Dysregulation of RNA polymerase I transcription during disease

A novel role for Top2α as a mediator of resistance to ribosomal DNA transcription inhibition

513 A Fra-1-regulated Gene Expression Network Required for Maintenance of Epithelial-mesenchymal Transition in Human Colon Cancer Cells

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

Ets-2 Is Induced by Oxidative Stress and Sensitizes Cells to H2O2-Induced Apoptosis: Implications for Down's Syndrome

606 - A novel role for Top2α as a mediator of resistance to ribosomal DNA transcription inhibition

Characterization and transcriptional analysis of the mouse Chromosome 16 cytokine receptor gene cluster

Transformation induced by Ewing's sarcoma associated EWS FLI-1 is suppressed by KRAB FLI-1

Ets-2 Is Induced by Oxidative Stress and Sensitizes Cells to H2O2-Induced Apoptosis: Implications for Down's Syndrome

Ets-2 Is Induced by Oxidative Stress and Sensitizes Cells to H2O2-Induced Apoptosis: Implications for Down's Syndrome: Volume 287, Number 4 (2001), pages 1003–1008

Epstein-Barr virus LMP1 blocks p16 super(INK4a)-RB pathway by promoting nuclear export of E2F4/5

Ets-2 is induced by oxidative stress and sensitizes cells to H(2)O(2)-induced apoptosis: implications for Down's syndrome

Ets-2 Is Induced by Oxidative Stress and Sensitizes Cells to H sub(2)O sub(2)-Induced Apoptosis: Implications for Down's Syndrome

Characterization of monoclonal antibodies specific to the transcription factor ETS-2 protein

Study of energy storage systems and environmental challenges of batteries

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

Canada’s Geothermal Energy Update in 2023

Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses

Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance

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