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Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo

Biochemical journal, 2001-09, Vol.358 (Pt 3), p.615-626

2001

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Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats

Neuroscience, 2002-11, Vol.114 (4), p.1091-1101

2002

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Human genome-wide expression analysis reorients the study of inflammatory mediators and biomechanics in osteoarthritis

Osteoarthritis and cartilage, 2015-11, Vol.23 (11), p.1939-1945

2015

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A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis

Osteoarthritis and cartilage, 2006-02, Vol.14 (2), p.95-100

Sandy, J.D.

2006

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Deficiency of hyaluronan synthase 1 ( Has1 ) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage

Osteoarthritis and cartilage, 2015-11, Vol.23 (11), p.1879-1889

2015

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Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage

Osteoarthritis and cartilage, 2005-04, Vol.13 (4), p.269-277

2005

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The structure of aggrecan fragments in human synovial fluid : evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

The Journal of clinical investigation, 1992-05, Vol.89 (5), p.1512-1516

1992

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The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis

Osteoarthritis and cartilage, 2011-09, Vol.19 (9), p.1081-1090

2011

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The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination

Osteoarthritis and cartilage, 2010-03, Vol.18 (3), p.297-302

2010

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The effects of oral glucosamine on joint health: is a change in research approach needed?

Osteoarthritis and cartilage, 2010-01, Vol.18 (1), p.5-11

2010

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Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain

The Journal of biological chemistry, 1991-05, Vol.266 (14), p.8683-8685

1991

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Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5–hyaluronan complexes in articular cartilages

Osteoarthritis and cartilage, 2007-07, Vol.15 (7), p.719-734

2007

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Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage

The Journal of biological chemistry, 1992-01, Vol.267 (2), p.1008-1014

1992

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Effects of injurious compression on matrix turnover around individual cells in calf articular cartilage explants

Journal of orthopaedic research, 1998-07, Vol.16 (4), p.490-499

1998

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ADAMTS4 (Aggrecanase-1) Activation on the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated Proteinase to Chondroitin Sulfate and Heparan Sulfate on Syndecan-1

The Journal of biological chemistry, 2004-03, Vol.279 (11), p.10042-10051

2004

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The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1

Biochemical journal, 2000-10, Vol.351 (Pt 1), p.161-166

2000

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Biosynthetic response of cartilage explants to dynamic compression

Journal of orthopaedic research, 1989-09, Vol.7 (5), p.619-636

1989

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Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production

Archives of biochemistry and biophysics, 2009-09, Vol.489 (1), p.118-126

2009

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Activation of the Proteolytic Activity of ADAMTS4 (Aggrecanase-1) by C-terminal Truncation

The Journal of biological chemistry, 2002-03, Vol.277 (13), p.11034-11041

2002

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Regulated Expression of ADAMTS Family Members in Follicles and Cumulus Oocyte Complexes: Evidence for Specific and Redundant Patterns During Ovulation

Biology of reproduction, 2005-05, Vol.72 (5), p.1241-1255

2005

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Superficial zone chondrocytes in normal and osteoarthritic human articular cartilages synthesize novel truncated forms of inter-alpha-trypsin inhibitor heavy chains which are attached to a chondroitin sulfate proteoglycan other than bikunin

Osteoarthritis and cartilage, 2008-11, Vol.16 (11), p.1343-1355

2008

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Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid

Osteoarthritis and cartilage, 2007-11, Vol.15 (11), p.1318-1325

2007

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ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures

Osteoarthritis and cartilage, 2006-04, Vol.14 (4), p.392-402

2006

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Removal of O-linked and N-linked oligosaccharides is required for optimum detection of NITEGE neoepitope on ADAMTS4-digested fetal aggrecans: implications for specific N-linked glycan-dependent aggrecanolysis at Glu373–Ala374

Osteoarthritis and cartilage, 2009-06, Vol.17 (6), p.777-781

2009

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Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine

Biochemical journal, 1998-10, Vol.335 ( Pt 1) (1), p.59-66

1998

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Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo

Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats

Human genome-wide expression analysis reorients the study of inflammatory mediators and biomechanics in osteoarthritis

A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis

Deficiency of hyaluronan synthase 1 ( Has1 ) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage

Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage

The structure of aggrecan fragments in human synovial fluid : evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis

The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination

The effects of oral glucosamine on joint health: is a change in research approach needed?

Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain

Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5–hyaluronan complexes in articular cartilages

Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage

Effects of injurious compression on matrix turnover around individual cells in calf articular cartilage explants

ADAMTS4 (Aggrecanase-1) Activation on the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated Proteinase to Chondroitin Sulfate and Heparan Sulfate on Syndecan-1

The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1

Biosynthetic response of cartilage explants to dynamic compression

Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production

Activation of the Proteolytic Activity of ADAMTS4 (Aggrecanase-1) by C-terminal Truncation

Regulated Expression of ADAMTS Family Members in Follicles and Cumulus Oocyte Complexes: Evidence for Specific and Redundant Patterns During Ovulation

Superficial zone chondrocytes in normal and osteoarthritic human articular cartilages synthesize novel truncated forms of inter-alpha-trypsin inhibitor heavy chains which are attached to a chondroitin sulfate proteoglycan other than bikunin

Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid

ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures

Removal of O-linked and N-linked oligosaccharides is required for optimum detection of NITEGE neoepitope on ADAMTS4-digested fetal aggrecans: implications for specific N-linked glycan-dependent aggrecanolysis at Glu373–Ala374

Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine

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