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Resistance to beta-lactam antibiotics: structure and mechanism based design of beta-lactamase inhibitors

Current medicinal chemistry, 2002-06, Vol.9 (12), p.1145-1165

2002

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Abstract 1335: Dual MCT1/4 inhibition promotes anti-tumor immunity in triple-negative breast cancer

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1335-1335

2021

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Spirocyclopropyl β-Lactams as Mechanism-Based Inhibitors of Serine β-Lactamases. Synthesis by Rhodium-Catalyzed Cyclopropanation of 6-Diazopenicillanate Sulfone

Journal of medicinal chemistry, 2003-06, Vol.46 (13), p.2569-2571

2003

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Synthesis and Structure−Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2376-2396

2003

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Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

Blood, 2012-11, Vol.120 (23), p.4621-4634

2012

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Abstract 1268: A novel treatment approach for melanoma by dually targeting MCT1 and MCT4 lactate transporters

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1268-1268

2021

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Dipolar Cycloaddition of Novel 6-(Nitrileoxidomethyl) Penam Sulfone: An Efficient Route to a New Class of β-Lactamase Inhibitors

Organic letters, 2000-10, Vol.2 (20), p.3087-3090

2000

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An Approach toward the Illudin Family of Sesquiterpenes Using the Tandem Cyclization−Cycloaddition Reaction of Rhodium Carbenoids

Journal of organic chemistry, 1997-03, Vol.62 (5), p.1317-1325

1997

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Abstract 5412: Expression and inhibition of monocarboxylate transporters in canine osteosarcoma

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.5412-5412

2017

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1355 Novel pharmacological approach to induce direct killing of cancer and activate antitumor immunity via inhibition of monocarboxylate transporters

Journal for immunotherapy of cancer, 2022-11, Vol.10 (Suppl 2), p.A1406-A1406

2022

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1381 Lactate modulation in cancer and immune cells is associated with antitumor efficacy of dual MCT1/MCT4 inhibitor NGY-091

Journal for immunotherapy of cancer, 2022-11, Vol.10 (Suppl 2), p.A1435-A1435

2022

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Abstract 5126: Modulation of lactate in the tumor microenvironment with lactate transporter inhibitor in a melanoma syngeneic mouse model

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.5126-5126

2018

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Abstract P3-07-21: Therapeutic efficacy of NGY-091 against triple negative breast cancer is mediated by direct cell killing and activation of antitumor immunity

Cancer research (Chicago, Ill.), 2023-03, Vol.83 (5_Supplement), p.P3-P3-07-21

2023

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Generation and Cycloaddition Behavior of Spirocyclic Carbonyl Ylides. Application to the Synthesis of the Pterosin Family of Sesquiterpenes

Journal of organic chemistry, 1996-01, Vol.61 (1), p.73-81

1996

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Synthetic studies toward Illudins and Ptaquilosin. A highly convergent approach via the dipolar cycloaddition of carbonyl ylides

Journal of the American Chemical Society, 1994-03, Vol.116 (6), p.2667-2668

1994

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Abstract 4053: NGY-B is a novel inhibitor of MCT transporters blocking lactate and glucose metabolisms

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.4053-4053

2022

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An efficient method to prepare α-sulfonyl hydroxamic acid derivatives

Tetrahedron letters, 2001-07, Vol.42 (28), p.4605-4607

2001

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Abstract 2652: Efficacy of a small molecule MCT1 and MCT4 transporter inhibitor in cancer

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2652-2652

2022

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Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new β-lactamase inhibitors

Bioorganic & medicinal chemistry letters, 2001-04, Vol.11 (8), p.997-1000

2001

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Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis

Journal of medicinal chemistry, 2010-01, Vol.53 (2), p.573-585

2010

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Abstract 1841: Selective inhibitors of nuclear export (SINE) activate multiple tumor suppressor pathways and kill prostate cancer cells across multiple genotypes in vitro and in vivo

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.1841-1841

2012

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Studies on Intramolecular Higher-Order Cycloaddition Reactions

Journal of organic chemistry, 1996-02, Vol.61 (3), p.842-850

1996

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Abstract 2580: Discovery of SINE: Selective inhibitors of nuclear export increase levels of regulatory proteins p53, p21, FOXO and IκB leading to apoptosis of malignant cells

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.2580-2580

2011

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Prelinical evaluation of selective inhibitors of nuclear export (SINE) CRM1 (XPO1) inhibitors in prostate cancer (PrCa)

Journal of clinical oncology, 2012-05, Vol.30 (15_suppl), p.e15200-e15200

2012

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Abstract 3775: Pharmacokinetic (PK) / pharmacodynamic (PD) and efficacy relationship of selective inhibitors of nuclear export (KPT-SINE)

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.3775-3775

2012

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Resistance to beta-lactam antibiotics: structure and mechanism based design of beta-lactamase inhibitors

Abstract 1335: Dual MCT1/4 inhibition promotes anti-tumor immunity in triple-negative breast cancer

Spirocyclopropyl β-Lactams as Mechanism-Based Inhibitors of Serine β-Lactamases. Synthesis by Rhodium-Catalyzed Cyclopropanation of 6-Diazopenicillanate Sulfone

Synthesis and Structure−Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

Abstract 1268: A novel treatment approach for melanoma by dually targeting MCT1 and MCT4 lactate transporters

Dipolar Cycloaddition of Novel 6-(Nitrileoxidomethyl) Penam Sulfone: An Efficient Route to a New Class of β-Lactamase Inhibitors

An Approach toward the Illudin Family of Sesquiterpenes Using the Tandem Cyclization−Cycloaddition Reaction of Rhodium Carbenoids

Abstract 5412: Expression and inhibition of monocarboxylate transporters in canine osteosarcoma

1355 Novel pharmacological approach to induce direct killing of cancer and activate antitumor immunity via inhibition of monocarboxylate transporters

1381 Lactate modulation in cancer and immune cells is associated with antitumor efficacy of dual MCT1/MCT4 inhibitor NGY-091

Abstract 5126: Modulation of lactate in the tumor microenvironment with lactate transporter inhibitor in a melanoma syngeneic mouse model

Abstract P3-07-21: Therapeutic efficacy of NGY-091 against triple negative breast cancer is mediated by direct cell killing and activation of antitumor immunity

Generation and Cycloaddition Behavior of Spirocyclic Carbonyl Ylides. Application to the Synthesis of the Pterosin Family of Sesquiterpenes

Synthetic studies toward Illudins and Ptaquilosin. A highly convergent approach via the dipolar cycloaddition of carbonyl ylides

Abstract 4053: NGY-B is a novel inhibitor of MCT transporters blocking lactate and glucose metabolisms

An efficient method to prepare α-sulfonyl hydroxamic acid derivatives

Abstract 2652: Efficacy of a small molecule MCT1 and MCT4 transporter inhibitor in cancer

Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new β-lactamase inhibitors

Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis

Abstract 1841: Selective inhibitors of nuclear export (SINE) activate multiple tumor suppressor pathways and kill prostate cancer cells across multiple genotypes in vitro and in vivo

Studies on Intramolecular Higher-Order Cycloaddition Reactions

Abstract 2580: Discovery of SINE: Selective inhibitors of nuclear export increase levels of regulatory proteins p53, p21, FOXO and IκB leading to apoptosis of malignant cells

Prelinical evaluation of selective inhibitors of nuclear export (SINE) CRM1 (XPO1) inhibitors in prostate cancer (PrCa)

Abstract 3775: Pharmacokinetic (PK) / pharmacodynamic (PD) and efficacy relationship of selective inhibitors of nuclear export (KPT-SINE)

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