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Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction

CNS spectrums, 2014-04, Vol.19 (2), p.121-133

2014

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Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism

European neuropsychopharmacology, 2014-01, Vol.24 (1), p.160-171

2014

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Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs

Biochemical pharmacology, 2015-05, Vol.95 (2), p.81-97

2015

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Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function

CNS spectrums, 2016-04, Vol.21 (2), p.143-161

2016

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Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review

Progress in neuro-psychopharmacology & biological psychiatry, 2016-11, Vol.71, p.27-38

2016

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Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5‑HT Receptor Mechanisms and Concerted Effects of 5‑HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine

ACS chemical neuroscience, 2015-07, Vol.6 (7), p.970-986

2015

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Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice

Neuropharmacology, 2013-10, Vol.73, p.147-159

2013

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Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus

Journal of psychopharmacology (Oxford), 2014-10, Vol.28 (10), p.891-902

2014

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Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus

European neuropsychopharmacology, 2016-02, Vol.26 (2), p.234-245

2016

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Making spatial prioritizations robust to climate change uncertainties: a case study with North American birds

Ecological applications, 2015-10, Vol.25 (7), p.1819-1831

2015

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Vortioxetine Treatment Reverses Subchronic PCP Treatment-Induced Cognitive Impairments: A Potential Role for Serotonin Receptor-Mediated Regulation of GABA Neurotransmission

Frontiers in pharmacology, 2018-03, Vol.9, p.162

2018

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S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression

Frontiers in pharmacology, 2018-01, Vol.8, p.978-978

2018

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The Pharmacology of Citalopram Enantiomers: The Antagonism by R‐Citalopram on the Effect of S‐Citalopram

Basic & clinical pharmacology & toxicology, 2006-08, Vol.99 (2), p.91-95

SANCHEZ, Connie

2006

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Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data

Pharmacology & therapeutics (Oxford), 2015-01, Vol.145, p.43-57

2015

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Characterization of pain-, anxiety-, and cognition-related behaviors in the complete Freund's adjuvant model of chronic inflammatory pain in Wistar-Kyoto rats

Frontiers in pain research (Lausanne, Switzerland), 2023-04, Vol.4, p.1131069-1131069

2023

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Involvement of 5-HT3 receptors in the action of vortioxetine in rat brain: Focus on glutamatergic and GABAergic neurotransmission

Neuropharmacology, 2016-09, Vol.108, p.73-81

2016

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Blockade of the high‐affinity noradrenaline transporter (NET) by the selective 5‐HT reuptake inhibitor escitalopram: an in vivo microdialysis study in mice

British journal of pharmacology, 2013-01, Vol.168 (1), p.103-116

2013

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Role of 5-HT3 Receptors in the Antidepressant Response

Pharmaceuticals, 2011-04, Vol.4 (4), p.603-629

2011

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Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action

Psychopharmacologia, 2012, Vol.219 (1), p.1-13

2012

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P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood–brain barrier in vivo

Neuropharmacology, 2016-04, Vol.103, p.104-111

2016

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Vortioxetine Improves Context Discrimination in Mice Through a Neurogenesis Independent Mechanism

Frontiers in pharmacology, 2018-03, Vol.9, p.204-204

2018

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Vortioxetine Differentially Modulates MK-801-Induced Changes in Visual Signal Detection Task Performance and Locomotor Activity

Frontiers in pharmacology, 2018-09, Vol.9, p.1024-1024

2018

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Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice

Pharmacology, biochemistry and behavior, 2015-08, Vol.135, p.70-82

2015

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Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats

The international journal of neuropsychopharmacology, 2014-10, Vol.17 (10), p.1695-1706

2014

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Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats

Behavioural brain research, 2013-11, Vol.256, p.520-528

2013

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Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction

Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism

Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs

Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function

Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review

Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5‑HT Receptor Mechanisms and Concerted Effects of 5‑HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine

Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice

Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus

Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus

Making spatial prioritizations robust to climate change uncertainties: a case study with North American birds

Vortioxetine Treatment Reverses Subchronic PCP Treatment-Induced Cognitive Impairments: A Potential Role for Serotonin Receptor-Mediated Regulation of GABA Neurotransmission

S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression

The Pharmacology of Citalopram Enantiomers: The Antagonism by R‐Citalopram on the Effect of S‐Citalopram

Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data

Characterization of pain-, anxiety-, and cognition-related behaviors in the complete Freund's adjuvant model of chronic inflammatory pain in Wistar-Kyoto rats

Involvement of 5-HT3 receptors in the action of vortioxetine in rat brain: Focus on glutamatergic and GABAergic neurotransmission

Blockade of the high‐affinity noradrenaline transporter (NET) by the selective 5‐HT reuptake inhibitor escitalopram: an in vivo microdialysis study in mice

Role of 5-HT3 Receptors in the Antidepressant Response

Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action

P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood–brain barrier in vivo

Vortioxetine Improves Context Discrimination in Mice Through a Neurogenesis Independent Mechanism

Vortioxetine Differentially Modulates MK-801-Induced Changes in Visual Signal Detection Task Performance and Locomotor Activity

Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice

Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats

Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats

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