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Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation

Journal of the American College of Cardiology, 2016-10, Vol.68 (16), p.1756-1764

2016

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Mutation of an A-kinase-anchoring protein causes long-QT syndrome

Proceedings of the National Academy of Sciences - PNAS, 2007-12, Vol.104 (52), p.20990-20995

2007

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Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity

Cell stem cell, 2020-11, Vol.27 (5), p.813-821.e6

2020

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Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

eLife, 2023-08, Vol.12

2023

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KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate

Proceedings of the National Academy of Sciences - PNAS, 2010-12, Vol.107 (52), p.22710-22715

2010

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Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels

Frontiers in physiology, 2022-11, Vol.13, p.902224-902224

2022

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Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (18), p.7103-7108

2012

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Potassium Channels as Therapeutic Targets in Pulmonary Arterial Hypertension

Biomolecules (Basel, Switzerland), 2022-09, Vol.12 (10), p.1341

2022

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Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements

Frontiers in physiology, 2022-07, Vol.13, p.903050-903050

2022

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Molecular basis of ranolazine block of LQT‐3 mutant sodium channels: evidence for site of action

British journal of pharmacology, 2006-05, Vol.148 (1), p.16-24

2006

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Cardiac Delayed Rectifier Potassium Channels in Health and Disease

Cardiac electrophysiology clinics, 2016-06, Vol.8 (2), p.307-322

2016

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Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers

Channels (Austin, Tex.), 2022-12, Vol.16 (1), p.173-184

2022

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Modeling tissue- and mutation- specific electrophysiological effects in the long QT syndrome: role of the Purkinje fiber

PloS one, 2014-06, Vol.9 (6), p.e97720-e97720

2014

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The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery

Journal of the American Heart Association, 2017-09, Vol.6 (9), p.n/a

2017

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Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry

The Journal of physiology, 2011-12, Vol.589 (24), p.6093-6104

2011

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cardiac IKs channel, complex indeed

Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (44), p.18751-18752

2010

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Electrotonic influences on action potential duration dispersion in small hearts: a simulation study

American journal of physiology. Heart and circulatory physiology, 2005-07, Vol.289 (1), p.H350-H360

2005

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Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1

The Journal of general physiology, 2012-02, Vol.139 (2), p.135-144

2012

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Molecular mechanisms of adrenergic stimulation in the heart

Heart rhythm, 2010-08, Vol.7 (8), p.1151-1153

2010

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A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response

PloS one, 2007-12, Vol.2 (12), p.e1258-e1258

2007

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Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics

The Journal of general physiology, 2013-01, Vol.141 (1), p.61-72

2013

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KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps

Nature communications, 2014-04, Vol.5 (1), p.3750-3750, Article 3750

2014

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Adrenergic regulation of a key cardiac potassium channel can contribute to atrial fibrillation: evidence from an IKs transgenic mouse

The Journal of physiology, 2008-01, Vol.586 (2), p.627-637

2008

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Human iPSC-derived cardiomyocytes and pyridyl-phenyl mexiletine analogs

Bioorganic & medicinal chemistry letters, 2021-08, Vol.46, p.128162-128162, Article 128162

2021

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An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval

Drug safety, 2016-05, Vol.39 (5), p.433-441

2016

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Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation

Mutation of an A-kinase-anchoring protein causes long-QT syndrome

Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate

Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels

Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels

Potassium Channels as Therapeutic Targets in Pulmonary Arterial Hypertension

Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements

Molecular basis of ranolazine block of LQT‐3 mutant sodium channels: evidence for site of action

Cardiac Delayed Rectifier Potassium Channels in Health and Disease

Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers

Modeling tissue- and mutation- specific electrophysiological effects in the long QT syndrome: role of the Purkinje fiber

The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery

Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry

cardiac IKs channel, complex indeed

Electrotonic influences on action potential duration dispersion in small hearts: a simulation study

Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1

Molecular mechanisms of adrenergic stimulation in the heart

A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response

Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics

KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps

Adrenergic regulation of a key cardiac potassium channel can contribute to atrial fibrillation: evidence from an IKs transgenic mouse

Human iPSC-derived cardiomyocytes and pyridyl-phenyl mexiletine analogs

An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval

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