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Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A2-like proteins using functional, structural and bioinformatics approaches

Scientific reports, 2019-01, Vol.9 (1), Article 510

2019

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Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism

Scientific reports, 2018-07, Vol.8 (1), p.10317-15, Article 10317

2018

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Structural and functional studies with mytoxin II from Bothrops moojeni reveal remarkable similarities and differences compared to other catalytically inactive phospholipases A2-like

Toxicon (Oxford), 2013-09, Vol.72, p.52-63

2013

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The synthetic varespladib molecule is a multi-functional inhibitor for PLA2 and PLA2-like ophidic toxins

Biochimica et biophysica acta. General subjects, 2021-07, Vol.1865 (7), p.129913-129913, Article 129913

2021

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Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)

Scientific reports, 2019-11, Vol.9 (1), p.1-13, Article 17203

2019

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Structural studies with crotoxin B from Crotalus durissus collilineatus venom suggest a heterodimeric assembly formed by two new isoforms

Biochimie, 2024-03, Vol.218, p.46-56

2024

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Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib

Biochimie, 2023-04, Vol.207, p.1-10

2023

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BthTX-II from Bothrops jararacussu venom has variants with different oligomeric assemblies: An example of snake venom phospholipases A2 versatility

International journal of biological macromolecules, 2021-11, Vol.191, p.255-266

2021

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Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha

Biochemical journal, 2021-07, Vol.478 (13), p.2715-2732

2021

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Structural basis of phospholipase A2-like myotoxin inhibition by chicoric acid, a novel potent inhibitor of ophidian toxins

Biochimica et biophysica acta. General subjects, 2018-12, Vol.1862 (12), p.2728-2737

2018

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Biochemical, pharmacological and structural characterization of BmooMP-I, a new P–I metalloproteinase from Bothrops moojeni venom

Biochimie, 2020-12, Vol.179, p.54-64

2020

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Structural evidence for a fatty acid-independent myotoxic mechanism for a phospholipase A2-like toxin

Biochimica et biophysica acta. Proteins and proteomics, 2018-03, Vol.1866 (3), p.473-481

2018

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Crystal structure of a phospholipase A2 from Bothrops asper venom: Insights into a new putative “myotoxic cluster”

Biochimie, 2017-02, Vol.133, p.95-102

2017

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Secondary hemostasis studies of crude venom and isolated proteins from the snake Crotalus durissus terrificus

International journal of biological macromolecules, 2019-06, Vol.131, p.127-133

2019

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Malignant Hyperthermia in Bariatric Surgery: A Case Study With Clinical, Pathophysiological, Biochemical and Biophysical Correlations

Journal of medical cases, 2020-10, Vol.11 (12), p.379-387

2020

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Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin

Acta crystallographica. Section D, Biological crystallography., 2015-10, Vol.71 (10), p.2066-2078

2015

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Structural and phylogenetic studies with MjTX-I reveal a multi-oligomeric toxin--a novel feature in Lys49-PLA2s protein class

PloS one, 2013-04, Vol.8 (4), p.e60610

2013

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Crystallization and preliminary X-ray diffraction studies of BmooPLA 2 -I, a platelet-aggregation inhibitor and hypotensive phospholipase A 2 from Bothrops moojeni venom

Acta crystallographica. Section F, Structural biology and crystallization communications, 2011-08, Vol.67 (8), p.900-902

2011

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Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A2-like proteins using functional, structural and bioinformatics approaches

Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism

Structural and functional studies with mytoxin II from Bothrops moojeni reveal remarkable similarities and differences compared to other catalytically inactive phospholipases A2-like

The synthetic varespladib molecule is a multi-functional inhibitor for PLA2 and PLA2-like ophidic toxins

Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)

Structural studies with crotoxin B from Crotalus durissus collilineatus venom suggest a heterodimeric assembly formed by two new isoforms

Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib

BthTX-II from Bothrops jararacussu venom has variants with different oligomeric assemblies: An example of snake venom phospholipases A2 versatility

Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha

Structural basis of phospholipase A2-like myotoxin inhibition by chicoric acid, a novel potent inhibitor of ophidian toxins

Biochemical, pharmacological and structural characterization of BmooMP-I, a new P–I metalloproteinase from Bothrops moojeni venom

Structural evidence for a fatty acid-independent myotoxic mechanism for a phospholipase A2-like toxin

Crystal structure of a phospholipase A2 from Bothrops asper venom: Insights into a new putative “myotoxic cluster”

Secondary hemostasis studies of crude venom and isolated proteins from the snake Crotalus durissus terrificus

Malignant Hyperthermia in Bariatric Surgery: A Case Study With Clinical, Pathophysiological, Biochemical and Biophysical Correlations

Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin

Structural and phylogenetic studies with MjTX-I reveal a multi-oligomeric toxin--a novel feature in Lys49-PLA2s protein class

Crystallization and preliminary X-ray diffraction studies of BmooPLA 2 -I, a platelet-aggregation inhibitor and hypotensive phospholipase A 2 from Bothrops moojeni venom

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