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Blood-Stage Malaria Parasite Antigens: Structure, Function, and Vaccine Potential

Journal of molecular biology, 2019-10, Vol.431 (21), p.4259-4280

2019

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Structure-based design of a strain transcending AMA1-RON2L malaria vaccine

Nature communications, 2023-09, Vol.14 (1), p.5345-5345, Article 5345

2023

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Structure‐based design of a Plasmodium vivax Duffy‐binding protein immunogen focuses the antibody response to functional epitopes

Protein science, 2024-08, Vol.33 (8), p.e5095-n/a

2024

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A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

Nature communications, 2021-03, Vol.12 (1), p.1750-12, Article 1750

2021

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Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine

PLoS pathogens, 2024-03, Vol.20 (3), p.e1011879-e1011879

2024

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Implications of conformational flexibility, lipid binding, and regulatory domains in cell-traversal protein CelTOS for apicomplexan migration

The Journal of biological chemistry, 2022-09, Vol.298 (9), p.102241-102241, Article 102241

2022

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Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein

Proceedings of the National Academy of Sciences - PNAS, 2016-05, Vol.113 (22), p.6277-6282

2016

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Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion

Proceedings of the National Academy of Sciences - PNAS, 2017-04, Vol.114 (16), p.4225-4230

2017

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Plasmodium falciparum exploits CD44 as a coreceptor for erythrocyte invasion

Blood, 2023-12, Vol.142 (23), p.2016-2028

2023

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Structural analysis of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for Plasmodium vivax malaria vaccine design

PLoS neglected tropical diseases, 2015-03, Vol.9 (3), p.e0003644-e0003644

2015

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Multistage protective anti-CelTOS monoclonal antibodies with cross-species sterile protection against malaria

Nature communications, 2024-08, Vol.15 (1), p.7487-14, Article 7487

2024

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A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine

Immunity (Cambridge, Mass.), 2023-02, Vol.56 (2), p.433-443.e5

2023

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Immunological characterization of a VIR protein family member (VIR-14) in Plasmodium vivax-infected subjects from different epidemiological regions in Africa and South America

PLoS neglected tropical diseases, 2023-04, Vol.17 (4), p.e0011229-e0011229

2023

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Red cell receptors as access points for malaria infection

Current opinion in hematology, 2016-05, Vol.23 (3), p.215-223

2016

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Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro

Scientific reports, 2024-01, Vol.14 (1), p.1260-1260, Article 1260

2024

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Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines

Cell reports (Cambridge), 2023-03, Vol.42 (3), p.112266, Article 112266

2023

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DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism

Blood, 2017-09, Vol.130 (12), p.1441-1444

2017

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Defining the interaction of the protease CpaA with its type II secretion chaperone CpaB and its contribution to virulence in Acinetobacter species

The Journal of biological chemistry, 2017-12, Vol.292 (48), p.19628-19638

2017

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A quantitative assay for binding and inhibition of Plasmodium falciparum Erythrocyte Binding Antigen 175 reveals high affinity binding depends on both DBL domains

Protein expression and purification, 2014-03, Vol.95, p.188-194

2014

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Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine

npj vaccines, 2023-02, Vol.8 (1), p.20-20, Article 20

2023

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RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination

Antiviral research, 2024-08, Vol.228, p.105937, Article 105937

2024

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Moderately Neutralizing Epitopes in Nonfunctional Regions Dominate the Antibody Response to Plasmodium falciparum EBA-140

Infection and immunity, 2019-04, Vol.87 (4)

2019

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The structure of Acinetobacter-secreted protease CpaA complexed with its chaperone CpaB reveals a novel mode of a T2SS chaperone–substrate interaction

The Journal of biological chemistry, 2019-09, Vol.294 (36), p.13344-13354

2019

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Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption

eLife, 2016-12, Vol.5

2016

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Duffy antigen is expressed during erythropoiesis in Duffy-negative individuals

Cell host & microbe, 2023-12, Vol.31 (12), p.2093-2106.e7

2023

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Blood-Stage Malaria Parasite Antigens: Structure, Function, and Vaccine Potential

Structure-based design of a strain transcending AMA1-RON2L malaria vaccine

Structure‐based design of a Plasmodium vivax Duffy‐binding protein immunogen focuses the antibody response to functional epitopes

A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine

Implications of conformational flexibility, lipid binding, and regulatory domains in cell-traversal protein CelTOS for apicomplexan migration

Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein

Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion

Plasmodium falciparum exploits CD44 as a coreceptor for erythrocyte invasion

Structural analysis of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for Plasmodium vivax malaria vaccine design

Multistage protective anti-CelTOS monoclonal antibodies with cross-species sterile protection against malaria

A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine

Immunological characterization of a VIR protein family member (VIR-14) in Plasmodium vivax-infected subjects from different epidemiological regions in Africa and South America

Red cell receptors as access points for malaria infection

Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro

Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines

DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism

Defining the interaction of the protease CpaA with its type II secretion chaperone CpaB and its contribution to virulence in Acinetobacter species

A quantitative assay for binding and inhibition of Plasmodium falciparum Erythrocyte Binding Antigen 175 reveals high affinity binding depends on both DBL domains

Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine

RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination

Moderately Neutralizing Epitopes in Nonfunctional Regions Dominate the Antibody Response to Plasmodium falciparum EBA-140

The structure of Acinetobacter-secreted protease CpaA complexed with its chaperone CpaB reveals a novel mode of a T2SS chaperone–substrate interaction

Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption

Duffy antigen is expressed during erythropoiesis in Duffy-negative individuals

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