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Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current

The Journal of pharmacology and experimental therapeutics, 2006-06, Vol.317 (3), p.1054-1063

2006

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Functional and pharmacological properties of canine ERG potassium channels

American journal of physiology. Heart and circulatory physiology, 2003-01, Vol.284 (1), p.H256-H267

2003

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Assessing use-dependent inhibition of the cardiac Na± current (INa) in the PatchXpress automated patch clamp

Journal of pharmacological and toxicological methods, 2010-09, Vol.62 (2), p.107-118

2010

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Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2493-2496

2010

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Improved throughput of PatchXpress hERG assay using intracellular potassium fluoride

Assay and drug development technologies, 2008-04, Vol.6 (2), p.235-241

2008

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MK-0448, a Specific Kv1.5 Inhibitor: Safety, Pharmacokinetics, and Pharmacodynamic Electrophysiology in Experimental Animal Models and Humans

Circulation. Arrhythmia and electrophysiology, 2012-12, Vol.5 (6), p.1193-1201

2012

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Saxitoxin is a gating modifier of HERG K+ channels

The Journal of general physiology, 2003-06, Vol.121 (6), p.583-598

2003

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The anesthetized guinea pig: An effective early cardiovascular derisking and lead optimization model

Journal of pharmacological and toxicological methods, 2013-07, Vol.68 (1), p.137-149

2013

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Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics

Journal of pharmacological and toxicological methods, 2008-09, Vol.58 (2), p.72-76

2008

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Halide ion effects on human Ether-à-go-go related gene potassium channel properties

Assay and drug development technologies, 2013-12, Vol.11 (9-10), p.544-550

2013

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Modeling of the adrenergic response of the human IKs current (hKCNQ1/hKCNE1) stably expressed in HEK-293 cells

American journal of physiology. Heart and circulatory physiology, 2008-11, Vol.295 (5), p.H1867-H1881

2008

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IV infusion rate affects pharmacokinetics and pharmacodynamic (QTc) response in pentobarbital-anesthetized guinea pigs

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e3-e3

2011

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A Novel Benzodiazepine that Activates Cardiac Slow Delayed Rectifier K+ Currents

Molecular pharmacology, 1998-07, Vol.54 (1), p.220-230

1998

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Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits

Circulation (New York, N.Y.), 2001-03, Vol.103 (11), p.1585-1590

2001

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Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (19), p.5390-5395

2007

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Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine

Circulation research, 1995, Vol.76 (1), p.110-119

1995

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Pharmacological Modulation of IKs: Potential for Antiarrhythmic Therapy

Current medicinal chemistry, 2004-01, Vol.11 (1), p.29-44

2004

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Flunarizine is a Highly Potent Inhibitor of Cardiac hERG Potassium Current

Journal of cardiovascular pharmacology, 2006-02, Vol.47 (2), p.211-220

2006

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Increasing IKs corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy

American journal of physiology. Heart and circulatory physiology, 2002-08, Vol.283 (2), p.H664

2002

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Increasing I Ks corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy

American journal of physiology. Heart and circulatory physiology, 2002-08, Vol.283 (2), p.H664-H670

2002

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Application of PatchXpress planar patch clamp technology to the screening of new drug candidates for cardiac KCNQ1/KCNE1 (I Ks) activity

Assay and drug development technologies, 2007-10, Vol.5 (5), p.617-628

2007

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Use-Dependent Effects of the Class III Antiarrhythmic Agent NE-10064 (Azimilide) on Cardiac Repolarization: Block of Delayed Rectifier Potassium and L-Type Calcium Currents

Journal of cardiovascular pharmacology, 1995-08, Vol.26 (2), p.259-271

1995

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Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective Iks-blocking class III antiarrhythmic agents

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1165-1168

2003

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In Vivo Canine Cardiac Electrophysiologic Profile of 1,4-Benzodiazepine Iks Blockers

Journal of cardiovascular pharmacology, 2003-07, Vol.42 (1), p.105-112

2003

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Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current

Functional and pharmacological properties of canine ERG potassium channels

Assessing use-dependent inhibition of the cardiac Na± current (INa) in the PatchXpress automated patch clamp

Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel

Improved throughput of PatchXpress hERG assay using intracellular potassium fluoride

MK-0448, a Specific Kv1.5 Inhibitor: Safety, Pharmacokinetics, and Pharmacodynamic Electrophysiology in Experimental Animal Models and Humans

Saxitoxin is a gating modifier of HERG K+ channels

The anesthetized guinea pig: An effective early cardiovascular derisking and lead optimization model

Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics

Halide ion effects on human Ether-à-go-go related gene potassium channel properties

Modeling of the adrenergic response of the human IKs current (hKCNQ1/hKCNE1) stably expressed in HEK-293 cells

IV infusion rate affects pharmacokinetics and pharmacodynamic (QTc) response in pentobarbital-anesthetized guinea pigs

A Novel Benzodiazepine that Activates Cardiac Slow Delayed Rectifier K+ Currents

Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits

Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP

Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine

Pharmacological Modulation of IKs: Potential for Antiarrhythmic Therapy

Flunarizine is a Highly Potent Inhibitor of Cardiac hERG Potassium Current

Increasing IKs corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy

Increasing I Ks corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy

Application of PatchXpress planar patch clamp technology to the screening of new drug candidates for cardiac KCNQ1/KCNE1 (I Ks) activity

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

Use-Dependent Effects of the Class III Antiarrhythmic Agent NE-10064 (Azimilide) on Cardiac Repolarization: Block of Delayed Rectifier Potassium and L-Type Calcium Currents

Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective Iks-blocking class III antiarrhythmic agents

In Vivo Canine Cardiac Electrophysiologic Profile of 1,4-Benzodiazepine Iks Blockers

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