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Friedlӓnder's synthesis of quinolines as a pivotal step in the development of bioactive heterocyclic derivatives in the current era of medicinal chemistry

Chemical biology & drug design, 2022-12, Vol.100 (6), p.1042-1085

2022

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Natural and synthetic naphthoquinones active against Trypanosoma cruzi: an initial step towards new drugs for Chagas disease

Current medicinal chemistry, 2011, Vol.18 (1), p.144

2011

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Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays

International journal of molecular sciences, 2019-12, Vol.21 (1), p.161

2019

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Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol

Molecules (Basel, Switzerland), 2023-05, Vol.28 (9), p.3959

2023

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N-Heterocyclic carbene copper( i ) complex-catalyzed synthesis of 2-aryl benzoxazoles and benzothiazoles

RSC advances, 2016-01, Vol.6 (85), p.82401-82408

2016

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Natural and Synthetic Naphthoquinones as Potential Anti-Infective Agents

Current topics in medicinal chemistry, 2021-01, Vol.21 (22), p.2046

2021

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Trypanothione Reductase: A Target for the Development of Anti- Trypanosoma cruzi Drugs

Mini reviews in medicinal chemistry, 2017-01, Vol.17 (11), p.939

2017

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Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs

Biomedicine & pharmacotherapy, 2023-08, Vol.164, p.114934-114934, Article 114934

2023

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A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo

International journal of molecular sciences, 2021-08, Vol.22 (16), p.8372

2021

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In Vivo and in vitro antitumor activity of tomatine in hepatocellular carcinoma

Frontiers in pharmacology, 2022-09, Vol.13, p.1003264-1003264

2022

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New Inhibitors of Bcr-Abl Based on 2,6,9-Trisubstituted Purine Scaffold Elicit Cytotoxicity in Chronic Myeloid Leukemia-Derived Cell Lines Sensitive and Resistant to TKIs

Pharmaceutics, 2024-05, Vol.16 (5), p.649

2024

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New Amino Naphthoquinone Derivatives as Anti-Trypanosoma cruzi Agents Targeting Trypanothione Reductase

Pharmaceutics, 2022-05, Vol.14 (6), p.1121

2022

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Synthesis and pharmacophore modelling of 2,6,9-trisubstituted purine derivatives and their potential role as apoptosis-inducing agents in cancer cell lines

Molecules (Basel, Switzerland), 2015-04, Vol.20 (4), p.6808-6826

2015

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Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia

Pharmaceutics, 2022-06, Vol.14 (6), p.1294

2022

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Substituted Purines as High-Affinity Histamine H3 Receptor Ligands

Pharmaceuticals (Basel, Switzerland), 2022-05, Vol.15 (5), p.573

2022

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(-)-Shikimic Acid as a Chiral Building Block for the Synthesis of New Cytotoxic 6-Aza-Analogues of Angucyclinones

Molecules (Basel, Switzerland), 2018-06, Vol.23 (6), p.1422

2018

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New short strategy for the synthesis of the dibenz[b,f]oxepin scaffold

Molecules (Basel, Switzerland), 2013-11, Vol.18 (12), p.14797-14806

2013

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Efficient indium-mediated dehalogenation of aromatics in ionic liquid media

Molecules (Basel, Switzerland), 2012-12, Vol.18 (1), p.398-407

2012

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Nature-inspired pyrrolo[2,3-d]pyrimidines targeting the histamine H 3 receptor

Bioorganic & medicinal chemistry, 2019-07, Vol.27 (14), p.3194

2019

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Studies on the Michael addition of naphthoquinones to sugar nitro olefins: first synthesis of polyhydroxylated hexahydro-11H-benzo[a]carbazole-5,6-diones and hexahydro-11bH-benzo[b]carbazole-6,11-diones

Tetrahedron, 2012-02, Vol.68 (5), p.1612-1621

2012

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State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures

Future medicinal chemistry, 2019-03, Vol.11 (6), p.617-638

2019

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Nature-inspired pyrrolo[2,3-d]pyrimidines targeting the histamine H3 receptor

Bioorganic & medicinal chemistry, 2019-07, Vol.27 (14), p.3194-3200

2019

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New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer

Bioorganic chemistry, 2024-10, Vol.151, p.107681, Article 107681

2024

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Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models

European journal of medicinal chemistry, 2023-01, Vol.246, p.114926-114926, Article 114926

2023

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New lead elements for histamine H 3 receptor ligands in the pyrrolo[2,3-d]pyrimidine class

Bioorganic & medicinal chemistry letters, 2018-09, Vol.28 (17), p.2890

2018

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Friedlӓnder's synthesis of quinolines as a pivotal step in the development of bioactive heterocyclic derivatives in the current era of medicinal chemistry

Natural and synthetic naphthoquinones active against Trypanosoma cruzi: an initial step towards new drugs for Chagas disease

Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays

Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol

N-Heterocyclic carbene copper( i ) complex-catalyzed synthesis of 2-aryl benzoxazoles and benzothiazoles

Natural and Synthetic Naphthoquinones as Potential Anti-Infective Agents

Trypanothione Reductase: A Target for the Development of Anti- Trypanosoma cruzi Drugs

Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs

A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo

In Vivo and in vitro antitumor activity of tomatine in hepatocellular carcinoma

New Inhibitors of Bcr-Abl Based on 2,6,9-Trisubstituted Purine Scaffold Elicit Cytotoxicity in Chronic Myeloid Leukemia-Derived Cell Lines Sensitive and Resistant to TKIs

New Amino Naphthoquinone Derivatives as Anti-Trypanosoma cruzi Agents Targeting Trypanothione Reductase

Synthesis and pharmacophore modelling of 2,6,9-trisubstituted purine derivatives and their potential role as apoptosis-inducing agents in cancer cell lines

Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia

Substituted Purines as High-Affinity Histamine H3 Receptor Ligands

(-)-Shikimic Acid as a Chiral Building Block for the Synthesis of New Cytotoxic 6-Aza-Analogues of Angucyclinones

New short strategy for the synthesis of the dibenz[b,f]oxepin scaffold

Efficient indium-mediated dehalogenation of aromatics in ionic liquid media

Nature-inspired pyrrolo[2,3-d]pyrimidines targeting the histamine H 3 receptor

Studies on the Michael addition of naphthoquinones to sugar nitro olefins: first synthesis of polyhydroxylated hexahydro-11H-benzo[a]carbazole-5,6-diones and hexahydro-11bH-benzo[b]carbazole-6,11-diones

State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures

Nature-inspired pyrrolo[2,3-d]pyrimidines targeting the histamine H3 receptor

New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer

Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models

New lead elements for histamine H 3 receptor ligands in the pyrrolo[2,3-d]pyrimidine class

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