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Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics

Annual review of neuroscience, 2016-07, Vol.39 (1), p.57-79

2016

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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

Cell, 2020-08, Vol.182 (4), p.976-991.e19

2020

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Stem-cell-derived human microglia transplanted in mouse brain to study human disease

Nature neuroscience, 2019-12, Vol.22 (12), p.2111-2116

2019

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Single-Cell Quantification of mRNA Expression in The Human Brain

Scientific reports, 2019-08, Vol.9 (1), p.12353-9, Article 12353

2019

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On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients

Alzheimer's & dementia, 2015-11, Vol.11 (11), p.1265-1276

2015

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A Self-Organizing miR-132/Ctbp2 Circuit Regulates Bimodal Notch Signals and Glial Progenitor Fate Choice during Spinal Cord Maturation

Developmental cell, 2014-08, Vol.30 (4), p.423-436

2014

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The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

Cell reports (Cambridge), 2019-04, Vol.27 (4), p.1293-1306.e6

2019

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Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans

Cell reports (Cambridge), 2020-09, Vol.32 (13), p.108189-108189, Article 108189

2020

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Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease

Nature neuroscience, 2023-03, Vol.26 (3), p.406-415

2023

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A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene

Brain (London, England : 1878), 2021-12, Vol.144 (12), p.3727-3741

2021

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Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease

Neurology, 2013-12, Vol.81 (24), p.2103-2106

2013

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Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: The need of larger datasets

Ageing research reviews, 2014-09, Vol.17, p.43-53

2014

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N‑Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42

Journal of the American Chemical Society, 2015-11, Vol.137 (46), p.14673-14685

2015

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Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease

PLoS biology, 2024-07, Vol.22 (7), p.e3002727

2024

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Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation

Neurobiology of aging, 2013-05, Vol.34 (5), p.1315-1327

2013

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β-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins

The FEBS journal, 2010-03, Vol.277 (6), p.1503-1518

2010

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An NSAID-like Compound, FT-9, Preferentially Inhibits γ-Secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1

Biochemistry (Easton), 2009-11, Vol.48 (46), p.10894-10904

2009

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γ-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons

Brain research, 2009-03, Vol.1262, p.89-99

2009

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Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease

Cell stem cell, 2021-10, Vol.28 (10), p.1805-1821.e8

2021

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Alteration of the micro RNA network during the progression of Alzheimer's disease

EMBO molecular medicine, 2013-10, Vol.5 (10), p.1613-1634

2013

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THU-203 Integrated spatial transcriptomics and machine learning derived histopathology measurements in steatotic liver disease unmasks biological heterogeneity of steatosis

Journal of hepatology, 2024-06, Vol.80, p.S567-S567

2024

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Alteration of the microRNA network during the progression of Alzheimer's disease

EMBO molecular medicine, 2013-10, Vol.5 (10), p.1613-1634

2013

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PLD3 gene and processing of APP

Nature (London), 2017-01, Vol.541 (7638), p.E1-E2

2017

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Unbiased profiling of miR‐132 targetome with implications in adult hippocampal neurogenesis and Alzheimer’s disease

Alzheimer's & dementia, 2021-12, Vol.17, p.e052013-n/a

2021

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Artificial intelligence for neurodegenerative experimental models

Alzheimer's & dementia, 2023-12, Vol.19 (12), p.5970-5987

2023

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Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

Stem-cell-derived human microglia transplanted in mouse brain to study human disease

Single-Cell Quantification of mRNA Expression in The Human Brain

On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients

A Self-Organizing miR-132/Ctbp2 Circuit Regulates Bimodal Notch Signals and Glial Progenitor Fate Choice during Spinal Cord Maturation

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene

Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease

Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: The need of larger datasets

N‑Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease

Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation

β-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins

An NSAID-like Compound, FT-9, Preferentially Inhibits γ-Secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1

γ-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease

Alteration of the micro RNA network during the progression of Alzheimer's disease

THU-203 Integrated spatial transcriptomics and machine learning derived histopathology measurements in steatotic liver disease unmasks biological heterogeneity of steatosis

Alteration of the microRNA network during the progression of Alzheimer's disease

PLD3 gene and processing of APP

Unbiased profiling of miR‐132 targetome with implications in adult hippocampal neurogenesis and Alzheimer’s disease

Artificial intelligence for neurodegenerative experimental models

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