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Impact of Phosphorothioate Chirality on Double‐Stranded siRNAs: A Systematic Evaluation of Stereopure siRNA Designs

Chembiochem : a European journal of chemical biology, 2020-05, Vol.21 (9), p.1304-1308

2020

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Identification of a Tricyclic PIII Chiral Auxiliary for Solid‐Supported Synthesis of Stereopure Phosphorothioate‐Containing Oligonucleotides

Chembiochem : a European journal of chemical biology, 2020-05, Vol.21 (9), p.1298-1303

2020

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Inhibitors of Ras/Raf-1 Interaction Identified by Two-Hybrid Screening Revert Ras-Dependent Transformation Phenotypes in Human Cancer Cells

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (22), p.14398-14403

2002

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ARX788, a Site-specific Anti-HER2 Antibody–Drug Conjugate, Demonstrates Potent and Selective Activity in HER2-low and T-DM1–resistant Breast and Gastric Cancers

Molecular cancer therapeutics, 2020-09, Vol.19 (9), p.1833-1843

2020

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Synthesis of 7-methoxybenzolactam-V8 using aminomercuration as a key reaction

Tetrahedron letters, 2001-06, Vol.42 (26), p.4317-4319

Sakamuri, Sukumar

2001

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Identification of a Tricyclic P III Chiral Auxiliary for Solid-Supported Synthesis of Stereopure Phosphorothioate-Containing Oligonucleotides

Chembiochem : a European journal of chemical biology, 2020-05, Vol.21 (9), p.1298-1303

2020

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Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors

Bioorganic & medicinal chemistry letters, 2001-05, Vol.11 (9), p.1113-1118

2001

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Synthesis of 7-methoxybenzolactam-V8 using a diastereoselective Strecker synthesis

Chemical communications (Cambridge, England), 2001-01 (5), p.475-476

2001

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Total Synthesis of Tubulysin U and V

Angewandte Chemie International Edition, 2006-11, Vol.45 (43), p.7235-7239

2006

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Abstract 5616: Tumor-targeted immune activation via a site-specific TLR7-agonist antibody-drug conjugate

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.5616-5616

2022

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Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors

Tetrahedron letters, 2000-12, Vol.41 (51), p.9949-9952

2000

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Total Synthesis of Tubulysin U and V

Angewandte Chemie International Edition, 2007-03, Vol.46 (14), p.2347-2348

2007

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Abstract 2849: Optimization and pharmacokinetic characterization of potent CXCR4 antagonist CovX-Bodies

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.2849-2849

2012

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Initial Design and Synthesis of Conformationally Restricted and Pharmacophore-Based Scaffold Hopping Analogs of a Ras Pathway Modulator and Evaluation of Their MAPK Inhibitory Activities

Letters in drug design & discovery, 2006-02, Vol.3 (1), p.44-48

2006

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Pharmacophore-Based discovery of substituted pyridines as novel dopamine transporter inhibitors

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (3), p.513-517

2003

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Design and modular parallel synthesis of a MCR derived α-helix mimetic protein–protein interaction inhibitor scaffold

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1740-1743

2006

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Discovery of a Novel Dopamine Transporter Inhibitor, 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-Methylphenyl Ketone, as a Potential Cocaine Antagonist through 3D-Database Pharmacophore Searching. Molecular Modeling, Structure−Activity Relationships, and Behavioral Pharmacological Studies

Journal of medicinal chemistry, 2000-02, Vol.43 (3), p.351-360

2000

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Total Synthesis of Tubulysin U and V

Angewandte Chemie, 2006-11, Vol.118 (43), p.7393-7397

2006

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Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (15), p.3957-3962

2004

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Total Synthesis of Tubulysin U and V

Angewandte Chemie, 2007-03, Vol.119 (14), p.2399-2400

2007

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Pharmacophore-Based discovery, synthesis, and biological evaluation of 4-phenyl-1-arylalkyl piperidines as dopamine transporter inhibitors

Bioorganic & medicinal chemistry letters, 2001-02, Vol.11 (4), p.495-500

2001

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Molecular Modeling, Structure–Activity Relationships and Functional Antagonism Studies of 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-Methylphenyl Ketones as a Novel Class of Dopamine Transporter Inhibitors

Bioorganic & medicinal chemistry, 2001-07, Vol.9 (7), p.1753-1764

2001

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Synthesis of novel spirocyclic cocaine analogs using the Suzuki coupling

Tetrahedron letters, 2000-03, Vol.41 (13), p.2055-2058

2000

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Synthesis and Modeling Study of (2S,5R,6R)- and (2S,5R,6S)-6-Hydroxy- 8-(1-decynyl)-benzolactam-V8 as Protein Kinase C Modulators

Organic letters, 2002-06, Vol.4 (13), p.2169-2172

2002

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2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors

Bioorganic & medicinal chemistry, 2003-03, Vol.11 (6), p.1123-1136

2003

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Impact of Phosphorothioate Chirality on Double‐Stranded siRNAs: A Systematic Evaluation of Stereopure siRNA Designs

Identification of a Tricyclic PIII Chiral Auxiliary for Solid‐Supported Synthesis of Stereopure Phosphorothioate‐Containing Oligonucleotides

Inhibitors of Ras/Raf-1 Interaction Identified by Two-Hybrid Screening Revert Ras-Dependent Transformation Phenotypes in Human Cancer Cells

ARX788, a Site-specific Anti-HER2 Antibody–Drug Conjugate, Demonstrates Potent and Selective Activity in HER2-low and T-DM1–resistant Breast and Gastric Cancers

Synthesis of 7-methoxybenzolactam-V8 using aminomercuration as a key reaction

Identification of a Tricyclic P III Chiral Auxiliary for Solid-Supported Synthesis of Stereopure Phosphorothioate-Containing Oligonucleotides

Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors

Synthesis of 7-methoxybenzolactam-V8 using a diastereoselective Strecker synthesis

Total Synthesis of Tubulysin U and V

Abstract 5616: Tumor-targeted immune activation via a site-specific TLR7-agonist antibody-drug conjugate

Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors

Total Synthesis of Tubulysin U and V

Abstract 2849: Optimization and pharmacokinetic characterization of potent CXCR4 antagonist CovX-Bodies

Initial Design and Synthesis of Conformationally Restricted and Pharmacophore-Based Scaffold Hopping Analogs of a Ras Pathway Modulator and Evaluation of Their MAPK Inhibitory Activities

Pharmacophore-Based discovery of substituted pyridines as novel dopamine transporter inhibitors

Design and modular parallel synthesis of a MCR derived α-helix mimetic protein–protein interaction inhibitor scaffold

Discovery of a Novel Dopamine Transporter Inhibitor, 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-Methylphenyl Ketone, as a Potential Cocaine Antagonist through 3D-Database Pharmacophore Searching. Molecular Modeling, Structure−Activity Relationships, and Behavioral Pharmacological Studies

Total Synthesis of Tubulysin U and V

Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator

Total Synthesis of Tubulysin U and V

Pharmacophore-Based discovery, synthesis, and biological evaluation of 4-phenyl-1-arylalkyl piperidines as dopamine transporter inhibitors

Molecular Modeling, Structure–Activity Relationships and Functional Antagonism Studies of 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-Methylphenyl Ketones as a Novel Class of Dopamine Transporter Inhibitors

Synthesis of novel spirocyclic cocaine analogs using the Suzuki coupling

Synthesis and Modeling Study of (2S,5R,6R)- and (2S,5R,6S)-6-Hydroxy- 8-(1-decynyl)-benzolactam-V8 as Protein Kinase C Modulators

2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors

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