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SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

Nature communications, 2022-07, Vol.13 (1), p.4416-4416, Article 4416

2022

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ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens

Antimicrobial agents and chemotherapy, 2020-08, Vol.64 (9)

2020

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Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine

Journal of virology, 2024-04, Vol.98 (4), p.e0013224

2024

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4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

PLoS pathogens, 2023-04, Vol.19 (4), p.e1011342-e1011342

2023

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Development of a novel progesterone analog in the treatment of traumatic brain injury

Neuropharmacology, 2019-02, Vol.145, p.292-298

2019

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Asymmetric synthesis of host-directed inhibitors of myxoviruses

Beilstein journal of organic chemistry, 2013-01, Vol.9 (1), p.197-203

2013

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Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.946-979

2018

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An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model

Science translational medicine, 2014-04, Vol.6 (232), p.232ra52

2014

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Non-nucleoside Inhibitors of the Measles Virus RNA-Dependent RNA Polymerase: Synthesis, Structure–Activity Relationships, and Pharmacokinetics

Journal of medicinal chemistry, 2012-05, Vol.55 (9), p.4220-4230

2012

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Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists

ACS medicinal chemistry letters, 2013-11, Vol.4 (11), p.1025-1030

2013

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A Stereoselective Synthesis of BMS-262084, an Azetidinone-Based Tryptase Inhibitor

Journal of organic chemistry, 2002-05, Vol.67 (11), p.3595-3600

2002

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A synthetic route to forskolin

Journal of the American Chemical Society, 1987-12, Vol.109 (26), p.8115-8116

1987

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Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents

Journal of medicinal chemistry, 1995-07, Vol.38 (14), p.2531-2540

1995

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An Efficient Large Scale Synthesis of 4-Isopropyl- and 4-Isopropyl-6-methoxybenzisothiazolones. [Erratum to document cited in CA122:160528]

Journal of organic chemistry, 1995-06, Vol.60 (13), p.4308-4308

1995

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An Efficient Large Scale Synthesis of 4-Isopropyl- and 4-Isopropyl-6-methoxybenzisothiazolones

Journal of organic chemistry, 1994-11, Vol.59 (23), p.7161-7163

1994

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A C6, C7 oxygen functionalized intermediate for the synthesis of forskolin: stereochemical control in an intramolecular Diels-Alder reaction

Tetrahedron letters, 1985, Vol.26 (28), p.3307-3310

1985

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A C 6, C 7 Oxygen Functionalized Intermediate for the Synthesis of Forskolin: Stereochemical Control in an Intramolecular Diels-Alder Reaction

Tetrahedron letters, 1985, Vol.26 (28), p.3307-3310

1985

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4,5-Dihydro-3-(methanesulfonamidophenyl)-1-phenyl-1H-2,4-benzodiazepines: A Novel Class III Antiarrhythmic Agents

Journal of medicinal chemistry, 1995-07, Vol.38 (14), p.2551-2556

1995

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Relationship of structure of bridged (2,6-dimethyl-4-pyridinyl)quinolones to mammalian topoisomerase II inhibition

Bioorganic & medicinal chemistry letters, 1993-08, Vol.3 (8), p.1711-1716

1993

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A Stereoselective Synthesis of BMS-262084, an Azetidinone-Based Tryptase Inhibitor

ChemInform, 2002-11, Vol.33 (44), p.227-227

2002

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Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Journal of virology, 2019-12, Vol.93 (24)

2019

Volltextzugriff (PDF)

Small-Molecule Antiviral β-d- N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Journal of virology, 2019-12, Vol.93 (24)

2019

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Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.4058-4084

2022

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Abstract 2649: Orally bioavailable small molecule CXCR4 antagonists with enhanced efficacy in mouse models of genitourinary cancers

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2649-2649

2022

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SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens

Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine

4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

Development of a novel progesterone analog in the treatment of traumatic brain injury

Asymmetric synthesis of host-directed inhibitors of myxoviruses

Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties

An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model

Non-nucleoside Inhibitors of the Measles Virus RNA-Dependent RNA Polymerase: Synthesis, Structure–Activity Relationships, and Pharmacokinetics

Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists

A Stereoselective Synthesis of BMS-262084, an Azetidinone-Based Tryptase Inhibitor

A synthetic route to forskolin

Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents

An Efficient Large Scale Synthesis of 4-Isopropyl- and 4-Isopropyl-6-methoxybenzisothiazolones. [Erratum to document cited in CA122:160528]

An Efficient Large Scale Synthesis of 4-Isopropyl- and 4-Isopropyl-6-methoxybenzisothiazolones

A C6, C7 oxygen functionalized intermediate for the synthesis of forskolin: stereochemical control in an intramolecular Diels-Alder reaction

A C 6, C 7 Oxygen Functionalized Intermediate for the Synthesis of Forskolin: Stereochemical Control in an Intramolecular Diels-Alder Reaction

4,5-Dihydro-3-(methanesulfonamidophenyl)-1-phenyl-1H-2,4-benzodiazepines: A Novel Class III Antiarrhythmic Agents

Relationship of structure of bridged (2,6-dimethyl-4-pyridinyl)quinolones to mammalian topoisomerase II inhibition

A Stereoselective Synthesis of BMS-262084, an Azetidinone-Based Tryptase Inhibitor

Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Small-Molecule Antiviral β-d- N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles

Abstract 2649: Orally bioavailable small molecule CXCR4 antagonists with enhanced efficacy in mouse models of genitourinary cancers

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