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Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease

Journal of neurochemistry, 2017-02, Vol.140 (4), p.561-575

2017

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Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification

Organic & biomolecular chemistry, 2014-10, Vol.12 (39), p.7659-7672

2014

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Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice

ACS chemical neuroscience, 2017-08, Vol.8 (8), p.1801-1811

2017

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σ2R/TMEM97 in retinal ganglion cell degeneration

Scientific reports, 2022-12, Vol.12 (1), p.20753-20753, Article 20753

2022

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Norbenzomorphan Scaffold: Chemical Tool for Modulating Sigma Receptor-Subtype Selectivity

ACS medicinal chemistry letters, 2017-04, Vol.8 (4), p.455-460

2017

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Identification of the gene that codes for the σ₂ receptor

Proceedings of the National Academy of Sciences - PNAS, 2017-07, Vol.114 (27), p.7160-7165

2017

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MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion

Neuroscience, 2023-04, Vol.515, p.96-107

2023

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Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain

Pharmacological reviews, 2021-01, Vol.73 (1), p.59-88

2021

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[2 + 2] Photochemical Cycloaddition/Ring Opening of 6-Alkenyl-2,3-dihydro-4-pyridones

Journal of organic chemistry, 2010-10, Vol.75 (19), p.6728-6731

2010

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Targeting σ2R/TMEM97 with novel aminotetralins

European journal of medicinal chemistry, 2022-12, Vol.243, p.114696-114696, Article 114696

2022

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The Sigma-2 receptor / transmembrane protein 97 (σ2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice

Neuropharmacology, 2021-02, Vol.184, p.108409-108409, Article 108409

2021

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Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties

European journal of medicinal chemistry, 2018-05, Vol.151, p.557-567

2018

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Highly specific σ2R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response

Proceedings of the National Academy of Sciences - PNAS, 2023-12, Vol.120 (52), p.1-e2306090120

2023

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Highly specific σ 2 R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response

Proceedings of the National Academy of Sciences - PNAS, 2023-12, Vol.120 (52), p.e2306090120

2023

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Neuroprotective Effects of σ2R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington’s Disease

ACS chemical neuroscience, 2022-10, Vol.13 (19), p.2852-2862

2022

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Small molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors

Neuropsychopharmacology (New York, N.Y.), 2018-08, Vol.43 (9), p.1867-1875

2018

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Facile syntheses of substituted, conformationally-constrained benzoxazocines and benzazocines via sequential multicomponent assembly and cyclization

Tetrahedron letters, 2011-12, Vol.52 (51), p.6855-6858

2011

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Neuroprotective Efficacy of a Sigma 2 Receptor/TMEM97 Modulator (DKR-1677) after Traumatic Brain Injury

ACS chemical neuroscience, 2019-03, Vol.10 (3), p.1595-1602

2019

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Neuroprotective Effects of σ 2 R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington's Disease

ACS chemical neuroscience, 2022-10, Vol.13 (19), p.2852-2862

2022

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Facile and Unified Approach to Skeletally Diverse, Privileged Scaffolds

Organic letters, 2011-05, Vol.13 (10), p.2590-2593

2011

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Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma2 Receptor/PGRMC1 Subtype-Selective Ligands

ChemMedChem, 2016-03, Vol.11 (6), p.556

2016

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Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma 2 Receptor/PGRMC1 Subtype-Selective Ligands

ChemMedChem, 2016-03, Vol.11 (6), p.556-561

2016

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Expedient Synthesis of Norbenzomorphan Library via Multicomponent Assembly Process Coupled with Ring-Closing Reactions

ACS combinatorial science, 2012-09, Vol.14 (9), p.496-502

2012

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High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model

ACS chemical neuroscience, 2018-05, Vol.9 (5), p.1014-1026

2018

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Identification of the gene that codes for the σ 2 receptor

Proceedings of the National Academy of Sciences - PNAS, 2017-07, Vol.114 (27), p.7160-7165

2017

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Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease

Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification

Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice

σ2R/TMEM97 in retinal ganglion cell degeneration

Norbenzomorphan Scaffold: Chemical Tool for Modulating Sigma Receptor-Subtype Selectivity

Identification of the gene that codes for the σ₂ receptor

MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion

Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain

[2 + 2] Photochemical Cycloaddition/Ring Opening of 6-Alkenyl-2,3-dihydro-4-pyridones

Targeting σ2R/TMEM97 with novel aminotetralins

The Sigma-2 receptor / transmembrane protein 97 (σ2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice

Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties

Highly specific σ2R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response

Highly specific σ 2 R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response

Neuroprotective Effects of σ2R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington’s Disease

Small molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors

Facile syntheses of substituted, conformationally-constrained benzoxazocines and benzazocines via sequential multicomponent assembly and cyclization

Neuroprotective Efficacy of a Sigma 2 Receptor/TMEM97 Modulator (DKR-1677) after Traumatic Brain Injury

Neuroprotective Effects of σ 2 R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington's Disease

Facile and Unified Approach to Skeletally Diverse, Privileged Scaffolds

Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma2 Receptor/PGRMC1 Subtype-Selective Ligands

Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma 2 Receptor/PGRMC1 Subtype-Selective Ligands

Expedient Synthesis of Norbenzomorphan Library via Multicomponent Assembly Process Coupled with Ring-Closing Reactions

High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model

Identification of the gene that codes for the σ 2 receptor

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