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Hemoglobin: Structure, Function and Allostery

Sub-cellular biochemistry, 2020, Vol.94, p.345-382

2020

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New developments in anti‐sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?

British journal of haematology, 2016-10, Vol.175 (1), p.24-30

2016

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Psiadia punctulata major flavonoids alleviate exaggerated vasoconstriction produced by advanced glycation end products

PloS one, 2019-09, Vol.14 (9), p.e0222101-e0222101

2019

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Docking and Molecular Dynamic Investigations of Phenylspirodrimanes as Cannabinoid Receptor-2 Agonists

Molecules (Basel, Switzerland), 2022-12, Vol.28 (1), p.44

2022

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Therapeutic Strategies to Alter the Oxygen Affinity of Sickle Hemoglobin

Hematology/oncology clinics of North America, 2014-04, Vol.28 (2), p.217-231

2014

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Metabolic Reprogramming in Sickle Cell Diseases: Pathophysiology and Drug Discovery Opportunities

International journal of molecular sciences, 2022-07, Vol.23 (13), p.7448

2022

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Bound water at protein-protein interfaces: partners, roles and hydrophobic bubbles as a conserved motif

PloS one, 2011-09, Vol.6 (9), p.e24712-e24712

2011

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Crystal structures of influenza A virus matrix protein M1: variations on a theme

PloS one, 2014-10, Vol.9 (10), p.e109510-e109510

2014

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Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase

PloS one, 2012-07, Vol.7 (7), p.e41680

2012

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Elucidating the Interaction between Pyridoxine 5'-Phosphate Oxidase and Dopa Decarboxylase: Activation of B6-Dependent Enzyme

International journal of molecular sciences, 2022-12, Vol.24 (1), p.642

2022

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Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies

Biochimie, 2021-04, Vol.183, p.18-29

2021

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A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells

Molecular pharmaceutics, 2018-05, Vol.15 (5), p.1954-1963

2018

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Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5‑HMF for the Treatment of Sickle Cell Disease

Molecular pharmaceutics, 2017-10, Vol.14 (10), p.3499-3511

2017

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Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease

Molecules (Basel, Switzerland), 2022-10, Vol.27 (20), p.6835

2022

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The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications

Medicinal research reviews, 2024-06

2024

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Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia

Nature communications, 2016-07, Vol.7 (1), p.12086-12086, Article 12086

2016

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On the catalytic mechanism and stereospecificity of Escherichia coli l‐threonine aldolase

The FEBS journal, 2014-01, Vol.281 (1), p.129-145

2014

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Correction: Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5′-phosphate, GABA and anti-epileptic drugs

Disease models & mechanisms, 2023-10, Vol.16 (10)

2023

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Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property

Expert opinion on therapeutic patents, 2022-02, Vol.32 (2), p.115-130

2022

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Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

The Journal of clinical investigation, 2014-06, Vol.124 (6), p.2750-2761

2014

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Exploration of Structure–Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14724-14739

2020

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Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers

International journal of nanomedicine, 2020-01, Vol.15, p.4001-4020

2020

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Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli: a pivotal enzyme in the vitamin B6 salvage pathway

The FEBS journal, 2023-12, Vol.290 (23), p.5628-5651

2023

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Characterization of the Staphylococcus aureus rRNA Methyltransferase Encoded by orfX, the Gene Containing the Staphylococcal Chromosome Cassette mec (SCCmec) Insertion Site

The Journal of biological chemistry, 2013-01, Vol.288 (1), p.132-140

2013

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Quantitative assessment of the in-vitro binding kinetics of antisickling aromatic aldehydes with hemoglobin A: A universal HPLC-UV/Vis method to quantitate Schiff-base adduct formation

Journal of pharmaceutical and biomedical analysis, 2023-01, Vol.223, p.115152-115152, Article 115152

2023

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Hemoglobin: Structure, Function and Allostery

New developments in anti‐sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?

Psiadia punctulata major flavonoids alleviate exaggerated vasoconstriction produced by advanced glycation end products

Docking and Molecular Dynamic Investigations of Phenylspirodrimanes as Cannabinoid Receptor-2 Agonists

Therapeutic Strategies to Alter the Oxygen Affinity of Sickle Hemoglobin

Metabolic Reprogramming in Sickle Cell Diseases: Pathophysiology and Drug Discovery Opportunities

Bound water at protein-protein interfaces: partners, roles and hydrophobic bubbles as a conserved motif

Crystal structures of influenza A virus matrix protein M1: variations on a theme

Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase

Elucidating the Interaction between Pyridoxine 5'-Phosphate Oxidase and Dopa Decarboxylase: Activation of B6-Dependent Enzyme

Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies

A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells

Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5‑HMF for the Treatment of Sickle Cell Disease

Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease

The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications

Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia

On the catalytic mechanism and stereospecificity of Escherichia coli l‐threonine aldolase

Correction: Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5′-phosphate, GABA and anti-epileptic drugs

Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

Exploration of Structure–Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers

Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli: a pivotal enzyme in the vitamin B6 salvage pathway

Characterization of the Staphylococcus aureus rRNA Methyltransferase Encoded by orfX, the Gene Containing the Staphylococcal Chromosome Cassette mec (SCCmec) Insertion Site

Quantitative assessment of the in-vitro binding kinetics of antisickling aromatic aldehydes with hemoglobin A: A universal HPLC-UV/Vis method to quantitate Schiff-base adduct formation

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