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Biopharmaceutics Permeability Classification of Lorcaserin, a Selective 5‑Hydroxytryptamine 2C Agonist: Method Suitability and Permeability Class Membership

Molecular pharmaceutics, 2013-12, Vol.10 (12), p.4739-4745

2013

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Metopimazine is primarily metabolized by a liver amidase in humans

Pharmacology research & perspectives, 2022-02, Vol.10 (1), p.e00903-n/a

2022

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Increased drug delivery to the brain by P-glycoprotein inhibition

Clinical pharmacology and therapeutics, 2000-09, Vol.68 (3), p.231-237

2000

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Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration

The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.645

2013

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Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist

Drug metabolism and disposition, 2012-04, Vol.40 (4), p.761-771

2012

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Identification of Human Sulfotransferases Involved in Lorcaserin N-Sulfamate Formation

Drug metabolism and disposition, 2016-04, Vol.44 (4), p.570-575

2016

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Identification of human UDP-glucuronosyltransferases involved in N-carbamoyl glucuronidation of lorcaserin

Drug metabolism and disposition, 2012-04, Vol.40 (4), p.772-778

2012

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Kinetics of 5-HT 2B Receptor Signaling: Profound Agonist-Dependent Effects on Signaling Onset and Duration

The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.645-659

2013

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Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain

ACS medicinal chemistry letters, 2017-12, Vol.8 (12), p.1309-1313

2017

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Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.322-326

2015

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Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid

The Journal of pharmacology and experimental therapeutics, 1997-11, Vol.283 (2), p.698

1997

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Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate‑1 Receptor

ACS medicinal chemistry letters, 2014-12, Vol.5 (12), p.1313-1317

2014

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Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (15), p.3034-3038

2015

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Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (17), p.4332-4335

2014

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Discovery of APD371: Identification of a Highly Potent and Selective CB 2 Agonist for the Treatment of Chronic Pain

ACS medicinal chemistry letters, 2017-12, Vol.8 (12), p.1309-1313

2017

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Cyclosporine pharmacokinetics and pharmacodynamics in African American and white subjects

Clinical pharmacology and therapeutics, 2001-05, Vol.69 (5), p.317-323

2001

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Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxam i des as potent and selective CB sub(2) receptor agonists

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.322-326

2015

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(7‑Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2‑a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists

ACS medicinal chemistry letters, 2014-12, Vol.5 (12), p.1334-1339

2014

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Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4404-4409

2012

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Molecular versus conventional methods: Clinical evaluation of different methods for the diagnosis of tuberculosis in Bangladesh

Journal of microbiology, immunology and infection, 2011-04, Vol.44 (2), p.101-105

2011

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Prochiral Sulfoxidation as a Probe for Multiple Forms of the Microsomal Flavin-Containing Monooxygenase: Studies with Rabbit FMO1, FMO2, FMO3, and FMO5 Expressed in Escherichia coli

Archives of biochemistry and biophysics, 1994-06, Vol.311 (2), p.369-377

1994

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Purification of macacque liver flavin-containing monooxygenase: A form of the enzyme related immunochemically to an isozyme expressed selectively in adult human liver

Biochimica et biophysica acta, Protein structure and molecular enzymology, 1993-03, Vol.1162 (1), p.127-134

1993

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Interaction of fluoroaniline with cytochrome P-450scc and myoglobin: temperature and pH dependence studies

Inorganica Chimica Acta, 1988, Vol.151 (1), p.49-54

1988

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Electron spin resonance studies of wild-type and mutant cytochromes P-450d: effects of mutations at proximal, aromatic and distal sites on g values

Biochimica et biophysica acta, 1990-01, Vol.1037 (1), p.122-128

1990

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Biopharmaceutics Permeability Classification of Lorcaserin, a Selective 5‑Hydroxytryptamine 2C Agonist: Method Suitability and Permeability Class Membership

Metopimazine is primarily metabolized by a liver amidase in humans

Increased drug delivery to the brain by P-glycoprotein inhibition

Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration

Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist

Identification of Human Sulfotransferases Involved in Lorcaserin N-Sulfamate Formation

Identification of human UDP-glucuronosyltransferases involved in N-carbamoyl glucuronidation of lorcaserin

Kinetics of 5-HT 2B Receptor Signaling: Profound Agonist-Dependent Effects on Signaling Onset and Duration

Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain

Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists

Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate‑1 Receptor

Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists

Discovery of APD371: Identification of a Highly Potent and Selective CB 2 Agonist for the Treatment of Chronic Pain

Cyclosporine pharmacokinetics and pharmacodynamics in African American and white subjects

Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxam i des as potent and selective CB sub(2) receptor agonists

(7‑Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2‑a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists

Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease

(7-Benzyloxy-2,3-dihydro- 1H -pyrrolo[1,2- a ]indol-1-yl)acetic Acids as S1P 1 Functional Antagonists

Molecular versus conventional methods: Clinical evaluation of different methods for the diagnosis of tuberculosis in Bangladesh

Prochiral Sulfoxidation as a Probe for Multiple Forms of the Microsomal Flavin-Containing Monooxygenase: Studies with Rabbit FMO1, FMO2, FMO3, and FMO5 Expressed in Escherichia coli

Purification of macacque liver flavin-containing monooxygenase: A form of the enzyme related immunochemically to an isozyme expressed selectively in adult human liver

Interaction of fluoroaniline with cytochrome P-450scc and myoglobin: temperature and pH dependence studies

Electron spin resonance studies of wild-type and mutant cytochromes P-450d: effects of mutations at proximal, aromatic and distal sites on g values

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