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To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?

International journal of molecular sciences, 2023-04, Vol.24 (7), p.6817

2023

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Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.511-523

2020

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Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

International journal for parasitology -- drugs and drug resistance, 2019-04, Vol.9, p.35-43

2019

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Hepatoprotective and Antioxidant Effect of Bauhinia hookeri Extract against Carbon Tetrachloride-Induced Hepatotoxicity in Mice and Characterization of Its Bioactive Compounds by HPLC-PDA-ESI-MS/MS

BioMed research international, 2014-01, Vol.2014 (2014), p.1-9

2014

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Hepatoprotective and antioxidant activity of Melaleuca styphelioides on carbon tetrachloride-induced hepatotoxicity in mice

Pharmaceutical biology, 2014-12, Vol.52 (12), p.1581-1590

2014

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Itraconazole, a cytochrome P450 inhibitor, enhanced the efficacy of praziquantel against Schistosoma mansoni infection and alleviated liver injury in mice

Experimental parasitology, 2022-08, Vol.239, p.108293-108293, Article 108293

2022

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Toxicity study of methanol extract of Rosa damascena trigintipetala in mice

Egyptian Journal of Chemistry, 2023-04

2023

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Pharmacological and antioxidant actions of garlic and.or onion in non-alcoholic fatty liver disease (NAFLD) in rats

Journal of the Egyptian Society of Parasitology, 2014-08, Vol.44 (2), p.295-308

2014

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Protective effect of Pelargonium graveolens against carbon tetrachloride-induced hepatotoxicity in mice and characterization of its bioactive constituents by HPLC–PDA–ESI–MS/MS analysis

Medicinal chemistry research, 2015-04, Vol.24 (4), p.1438-1448

2015

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Response of Schistosoma mansoni Isolates Having Different Drug Sensitivity to Praziquantel Over Several Life Cycle Passages with and Without Therapeutic Pressure

The Journal of parasitology, 2008-04, Vol.94 (2), p.537-541

2008

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Determination of ED50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates

International journal for parasitology, 2004-07, Vol.34 (8), p.979-987

2004

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Pharmacological and Antioxidant Actions of Garlic and - or Onion in Non Alcoholic Fatty Liver Disease ( Nafld ) in Rats

Journal of the Egyptian Society of Parasitology, 2014-08, Vol.44 (2), p.295-308

2014

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DRUG-METABOLIZING ENZYMES AND PRAZIQUANTEL BIOAVAILABILITY IN MICE HARBORING SCHISTOSOMA MANSONI ISOLATES OF DIFFERENT DRUG SUSCEPTIBILITIES

The Journal of parasitology, 2006-12, Vol.92 (6), p.1344-1349

2006

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To Target or Not to Target ISchistosoma mansoni/I Cyclic Nucleotide Phosphodiesterase 4A?

International journal of molecular sciences, 2023-04, Vol.24 (7)

2023

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Concomitant administration of atorvastatin with N-acetylcysteine mitigates liver injury and steatosis in experimental non-alcoholic fatty liver disease

Journal of applied pharmaceutical science, 2019-07, Vol.9 (7), p.50-57

2019

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Effect of Ficus sycomorus and Azadirachta indica extracts on liver state of mice infected with Schistosoma mansoni

Journal of the Egyptian Society of Parasitology, 2011-04, Vol.41 (1), p.77

2011

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Assessment of Combined Therapy of Recombinant Glutathione S-Transferase 26 and Praziquantel on Immunoparasitological Responses

Arzneimittel-Forschung, 2000-10, Vol.50 (10), p.929-935

2000

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Determination of ED 50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates

International journal for parasitology, 2004, Vol.34 (8), p.979-987

2004

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DRUG-METABOLIZING ENZYMES AND PRAZIQUANTEL BIOAVAILABILITY IN MICE HARBORING SCHISTOSOMA MANSONI ISOLATES OF DIFFERENT DRUG SUSCEPTIBILITIES

The Journal of parasitology, 2006-12, Vol.92 (6), p.1344-1349

2006

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Co-administration of metformin and N-acetylcysteine with dietary control improves the biochemical and histological manifestations in rats with non-alcoholic fatty liver

Research in pharmaceutical sciences, 2016-01, Vol.11 (5), p.374-382

2016

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Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni

Memórias do Instituto Oswaldo Cruz, 2011-11, Vol.106 (7), p.814-822

2011

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Effect of Ketoconazole, a Cytochrome P450 Inhibitor, on the Efficacy of Quinine and Halofantrine against Schistosoma mansoni in Mice

Korean journal of parasitology, 2013-04, Vol.51 (2), p.165-175

2013

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The phosphodiesterase-4 inhibitor roflumilast impacts Schistosoma mansoni ovipositing in vitro but displays only modest antischistosomal activity in vivo

Experimental parasitology, 2020-01, Vol.208, p.107793-107793, Article 107793

2020

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Effect of Ketoconazole, a Cytochrome P450 Inhibitor, on the Efficacy of Quinine and Halofantrine against Schistosoma mansoni in Mice

Korean journal of parasitology, 2013, Vol.51 (2), p.165-175

2013

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Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages

PLoS neglected tropical diseases, 2020-07, Vol.14 (7), p.e0008447

2020

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To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

Hepatoprotective and Antioxidant Effect of Bauhinia hookeri Extract against Carbon Tetrachloride-Induced Hepatotoxicity in Mice and Characterization of Its Bioactive Compounds by HPLC-PDA-ESI-MS/MS

Hepatoprotective and antioxidant activity of Melaleuca styphelioides on carbon tetrachloride-induced hepatotoxicity in mice

Itraconazole, a cytochrome P450 inhibitor, enhanced the efficacy of praziquantel against Schistosoma mansoni infection and alleviated liver injury in mice

Toxicity study of methanol extract of Rosa damascena trigintipetala in mice

Pharmacological and antioxidant actions of garlic and.or onion in non-alcoholic fatty liver disease (NAFLD) in rats

Protective effect of Pelargonium graveolens against carbon tetrachloride-induced hepatotoxicity in mice and characterization of its bioactive constituents by HPLC–PDA–ESI–MS/MS analysis

Response of Schistosoma mansoni Isolates Having Different Drug Sensitivity to Praziquantel Over Several Life Cycle Passages with and Without Therapeutic Pressure

Determination of ED50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates

Pharmacological and Antioxidant Actions of Garlic and - or Onion in Non Alcoholic Fatty Liver Disease ( Nafld ) in Rats

DRUG-METABOLIZING ENZYMES AND PRAZIQUANTEL BIOAVAILABILITY IN MICE HARBORING SCHISTOSOMA MANSONI ISOLATES OF DIFFERENT DRUG SUSCEPTIBILITIES

To Target or Not to Target ISchistosoma mansoni/I Cyclic Nucleotide Phosphodiesterase 4A?

Concomitant administration of atorvastatin with N-acetylcysteine mitigates liver injury and steatosis in experimental non-alcoholic fatty liver disease

Effect of Ficus sycomorus and Azadirachta indica extracts on liver state of mice infected with Schistosoma mansoni

Assessment of Combined Therapy of Recombinant Glutathione S-Transferase 26 and Praziquantel on Immunoparasitological Responses

Determination of ED 50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates

DRUG-METABOLIZING ENZYMES AND PRAZIQUANTEL BIOAVAILABILITY IN MICE HARBORING SCHISTOSOMA MANSONI ISOLATES OF DIFFERENT DRUG SUSCEPTIBILITIES

Co-administration of metformin and N-acetylcysteine with dietary control improves the biochemical and histological manifestations in rats with non-alcoholic fatty liver

Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni

Effect of Ketoconazole, a Cytochrome P450 Inhibitor, on the Efficacy of Quinine and Halofantrine against Schistosoma mansoni in Mice

The phosphodiesterase-4 inhibitor roflumilast impacts Schistosoma mansoni ovipositing in vitro but displays only modest antischistosomal activity in vivo

Effect of Ketoconazole, a Cytochrome P450 Inhibitor, on the Efficacy of Quinine and Halofantrine against Schistosoma mansoni in Mice

Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages

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