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RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits

Human molecular genetics, 2019-11, Vol.28 (21), p.3552-3568

2019

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Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

Human molecular genetics, 2012-02, Vol.21 (3), p.511-525

2012

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The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A

The Journal of biological chemistry, 2019-03, Vol.294 (13), p.4738-4758

2019

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LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity

Human molecular genetics, 2014-12, Vol.23 (25), p.6779-6796

2014

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Pathophysiology and Neuroimmune Interactions Underlying Parkinson's Disease and Traumatic Brain Injury

International journal of molecular sciences, 2023-04, Vol.24 (8), p.7186

2023

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LRRK2-Related Parkinson's Disease Due to Altered Endolysosomal Biology With Variable Lewy Body Pathology: A Hypothesis

Frontiers in neuroscience, 2020-06, Vol.14, p.556-556

2020

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Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinsons Disease

Current neuropharmacology, 2016-01, Vol.14 (3), p.238-249

2016

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LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy

Autophagy, 2012-04, Vol.8 (4), p.692-693

2012

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Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB

Cell death & disease, 2022-12, Vol.13 (12), p.1047-11, Article 1047

2022

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Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

Molecular neurodegeneration, 2018-01, Vol.13 (1), p.3-3, Article 3

2018

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Targeting LRRK2 mRNA stability in Parkinson's disease

Trends in neurosciences (Regular ed.), 2024-01, Vol.47 (1), p.1-3

2024

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Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations

Cells (Basel, Switzerland), 2020-07, Vol.9 (7), p.1719

2020

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RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A

Frontiers in molecular neuroscience, 2018-11, Vol.11, p.417-417

2018

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The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization

Biology open, 2022-08, Vol.11 (8)

2022

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Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions

Cell death discovery, 2020-06, Vol.6 (1), p.45-45, Article 45

2020

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Protocol to measure centrosome cohesion deficits mediated by pathogenic LRRK2 in cultured cells using confocal microscopy

STAR protocols, 2023-03, Vol.4 (1), p.102024-102024, Article 102024

2023

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Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients

Toxicology reports, 2017-01, Vol.4, p.188-193

2017

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Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

iScience, 2022-06, Vol.25 (6), p.104476-104476, Article 104476

2022

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Cellular effects mediated by pathogenic LRRK2: homing in on Rab-mediated processes

Biochemical Society transactions, 2017-02, Vol.45 (1), p.147-154

2017

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Synapsins as regulators of neurotransmitter release

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 1999-02, Vol.354 (1381), p.269-279

1999

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A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells

NPJ Parkinson's Disease, 2024-01, Vol.10 (1), p.12-12, Article 12

2024

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Autophagy researchers

Autophagy, 2014-07, Vol.10 (7), p.1149-1152

2014

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Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation

Biochemical Society transactions, 2023-04, Vol.51 (2), p.587-595

2023

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A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease

Parkinson's disease, 2012-01, Vol.2012, p.324521-9

2012

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A delayed response enhancement during hippocampal presynaptic plasticity in mice

The Journal of physiology, 2007-08, Vol.583 (1), p.129-143

2007

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RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity

Pathophysiology and Neuroimmune Interactions Underlying Parkinson's Disease and Traumatic Brain Injury

LRRK2-Related Parkinson's Disease Due to Altered Endolysosomal Biology With Variable Lewy Body Pathology: A Hypothesis

Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinsons Disease

LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy

Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

Targeting LRRK2 mRNA stability in Parkinson's disease

Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations

RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A

The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization

Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions

Protocol to measure centrosome cohesion deficits mediated by pathogenic LRRK2 in cultured cells using confocal microscopy

Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients

Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

Cellular effects mediated by pathogenic LRRK2: homing in on Rab-mediated processes

Synapsins as regulators of neurotransmitter release

A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells

Autophagy researchers

Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation

A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease

A delayed response enhancement during hippocampal presynaptic plasticity in mice

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