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Targeting protein prenylation for cancer therapy

Nature reviews. Cancer, 2011-11, Vol.11 (11), p.775

2011

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Targeting protein tyrosine phosphatases for anticancer drug discovery

Current pharmaceutical design, 2010-06, Vol.16 (16), p.1843

2010

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GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

Nature communications, 2018-12, Vol.9 (1), p.5154-9, Article 5154

2018

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A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation

Cancer research (Chicago, Ill.), 2013-03, Vol.73 (6), p.1922-1933

2013

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Protective role of Spirulina platensis against acute deltamethrin-induced toxicity in rats

PloS one, 2013-09, Vol.8 (9), p.e72991

2013

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Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer

Clinical cancer research, 2021-07, Vol.27 (14), p.4012-4024

2021

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Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors

Nature protocols, 2011-10, Vol.6 (11), p.1775-1791

2011

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Regulation of Matrix Metalloproteinase Genes by E2F Transcription Factors: Rb-Raf-1 Interaction as a Novel Target for Metastatic Disease

Cancer research (Chicago, Ill.), 2012-01, Vol.72 (2), p.516-526

2012

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RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer

Cancer research (Chicago, Ill.), 2012-10, Vol.72 (19), p.5025-5034

2012

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Development of o‑Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7392-7416

2012

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Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

Journal of medicinal chemistry, 2008-08, Vol.51 (16), p.4948-4956

2008

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Oxadiazole-isopropylamides as Potent and Noncovalent Proteasome Inhibitors

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.3783-3805

2013

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Searching for the elusive targets of farnesyltransferase inhibitors

Nature reviews. Cancer, 2003-12, Vol.3 (12), p.945-951

2003

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Angina bullosa haemorrhagica: a systematic review and proposal for diagnostic criteria

International journal of oral and maxillofacial surgery, 2019-01, Vol.48 (1), p.28-39

2019

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Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis

Molecular and Cellular Biology, 2005-11, Vol.25 (21), p.9369-9382

2005

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Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice

Cancer research (Chicago, Ill.), 2003-03, Vol.63 (6), p.1270-1279

2003

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Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT

Investigational new drugs, 2011-12, Vol.29 (6), p.1381-1389

2011

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Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice

Clinical cancer research, 2011-05, Vol.17 (9), p.2852-2862

2011

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Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.1978-1998

2012

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Geranylgeranyltransferase I Inhibitors Target RalB To Inhibit Anchorage-Dependent Growth and Induce Apoptosis and RalA To Inhibit Anchorage-Independent Growth

Molecular and Cellular Biology, 2007-11, Vol.27 (22), p.8003-8014

2007

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Protein farnesylation: Implications for normal physiology, malignant transformation, and cancer therapy

Cancer cell, 2005-04, Vol.7 (4), p.297-300

Sebti, Saïd M.

2005

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Lysophosphatidic acid acyltransferase beta regulates mTOR signaling

PloS one, 2013, Vol.8 (10), p.e78632-e78632

2013

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Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Bioorganic & medicinal chemistry, 2010-08, Vol.18 (15), p.5576-5592

2010

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The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner

The Journal of biological chemistry, 2011-03, Vol.286 (11), p.9382-9392

2011

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