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Fragment-based screening identifies inhibitors of ATPase activity and of hexamer formation of Cagα from the Helicobacter pylori type IV secretion system

Scientific reports, 2019-04, Vol.9 (1), p.6474-6474, Article 6474

2019

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Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43

Biochemistry (Easton), 2017-05, Vol.56 (17), p.2261-2270

2017

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A “Drug Sweeping” State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa

Structure (London), 2021-03, Vol.29 (3), p.261-274.e6

2021

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MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections

Frontiers in microbiology, 2018-07, Vol.9, p.1547-1547

2018

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Aldolase is essential for energy production and bridging adhesin-actin cytoskeletal interactions during parasite invasion of host cells

Cell host & microbe, 2009-04, Vol.5 (4), p.353-364

2009

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Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli

The Journal of biological chemistry, 2011-11, Vol.286 (46), p.40219-40231

2011

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Stereospecific Proton Transfer by a Mobile Catalyst in Mammalian Fructose-1,6-bisphosphate Aldolase

The Journal of biological chemistry, 2007-10, Vol.282 (42), p.31028-31037

2007

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Mechanism of Aldolase Control of Sorting Nexin 9 Function in Endocytosis

The Journal of biological chemistry, 2010-04, Vol.285 (16), p.11983-11990

2010

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A Hydrophobic Pocket in the Active Site of Glycolytic Aldolase Mediates Interactions with Wiskott-Aldrich Syndrome Protein

The Journal of biological chemistry, 2007-05, Vol.282 (19), p.14309-14315

2007

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Synthesis and Biochemical Evaluation of Selective Inhibitors of Class II Fructose Bisphosphate Aldolases: Towards New Synthetic Antibiotics

Chemistry : a European journal, 2008-09, Vol.14 (28), p.8521-8529

2008

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Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases

The Journal of biological chemistry, 2018-05, Vol.293 (20), p.7737-7753

2018

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Targeting a moonlighting function of aldolase induces apoptosis in cancer cells

Cell death & disease, 2019-09, Vol.10 (10), p.712-16, Article 712

2019

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Covalent Intermediate Trapped in 2-Keto-3-Deoxy-6-Phosphogluconate (KDPG) Aldolase Structure at 1.95-Å Resolution

Proceedings of the National Academy of Sciences - PNAS, 2001-03, Vol.98 (7), p.3679-3684

2001

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Structural Analysis and Inhibition of TraE from the pKM101 Type IV Secretion System

The Journal of biological chemistry, 2016-11, Vol.291 (45), p.23817-23829

2016

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Isomer activation controls stereospecificity of class I fructose-1,6-bisphosphate aldolases

The Journal of biological chemistry, 2017-12, Vol.292 (48), p.19849-19860

2017

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Crystal Structures of the Organomercurial Lyase MerB in Its Free and Mercury-bound Forms

The Journal of biological chemistry, 2009-01, Vol.284 (2), p.938-944

2009

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Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (5), p.1735-1737

2008

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Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cagα of Helicobacter pylori

Biochemistry and cell biology, 2024-06, Vol.102 (3), p.226-237

2024

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A Conserved Glutamate Residue Exhibits Multifunctional Catalytic Roles in d-Fructose-1,6-bisphosphate Aldolases

The Journal of biological chemistry, 2002-03, Vol.277 (11), p.9474-9483

2002

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Induced Fit Movements and Metal Cofactor Selectivity of Class II Aldolases

The Journal of biological chemistry, 2004-03, Vol.279 (12), p.11825-11833

2004

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Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase

Journal of medicinal chemistry, 2018-12, Vol.61 (23), p.10558-10572

2018

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Crystal Structures of DNA-Whirly Complexes and Their Role in Arabidopsis Organelle Genome Repair

The Plant cell, 2010-06, Vol.22 (6), p.1849-1867

2010

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Promiscuous substrate catalysis in tagatose-bisphosphate aldolase

Acta crystallographica. Section A, Foundations and advances, 2014-08, Vol.70 (a1), p.C467-C467

2014

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Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan

Acta crystallographica. Section F, Structural biology communications, 2019-06, Vol.75 (6), p.405-411

2019

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Structure–Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis

ACS infectious diseases, 2016-10, Vol.2 (10), p.702-713

2016

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Fragment-based screening identifies inhibitors of ATPase activity and of hexamer formation of Cagα from the Helicobacter pylori type IV secretion system

Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43

A “Drug Sweeping” State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa

MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections

Aldolase is essential for energy production and bridging adhesin-actin cytoskeletal interactions during parasite invasion of host cells

Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli

Stereospecific Proton Transfer by a Mobile Catalyst in Mammalian Fructose-1,6-bisphosphate Aldolase

Mechanism of Aldolase Control of Sorting Nexin 9 Function in Endocytosis

A Hydrophobic Pocket in the Active Site of Glycolytic Aldolase Mediates Interactions with Wiskott-Aldrich Syndrome Protein

Synthesis and Biochemical Evaluation of Selective Inhibitors of Class II Fructose Bisphosphate Aldolases: Towards New Synthetic Antibiotics

Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases

Targeting a moonlighting function of aldolase induces apoptosis in cancer cells

Covalent Intermediate Trapped in 2-Keto-3-Deoxy-6-Phosphogluconate (KDPG) Aldolase Structure at 1.95-Å Resolution

Structural Analysis and Inhibition of TraE from the pKM101 Type IV Secretion System

Isomer activation controls stereospecificity of class I fructose-1,6-bisphosphate aldolases

Crystal Structures of the Organomercurial Lyase MerB in Its Free and Mercury-bound Forms

Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases

Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cagα of Helicobacter pylori

A Conserved Glutamate Residue Exhibits Multifunctional Catalytic Roles in d-Fructose-1,6-bisphosphate Aldolases

Induced Fit Movements and Metal Cofactor Selectivity of Class II Aldolases

Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase

Crystal Structures of DNA-Whirly Complexes and Their Role in Arabidopsis Organelle Genome Repair

Promiscuous substrate catalysis in tagatose-bisphosphate aldolase

Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan

Structure–Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis

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