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Adaptive designs in clinical trials: why use them, and how to run and report them

BMC medicine, 2018-02, Vol.16 (1), p.29-29, Article 29

2018

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Prostate Radiotherapy for Metastatic Hormone-sensitive Prostate Cancer: A STOPCAP Systematic Review and Meta-analysis

European urology, 2019-07, Vol.76 (1), p.115-124

2019

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Addition of docetaxel or bisphosphonates to standard of care in men with localised or metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

The lancet oncology, 2016-02, Vol.17 (2), p.243-256

2016

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Practical methods for incorporating summary time-to-event data into meta-analysis

Trials, 2007-06, Vol.8 (1), p.16-16, Article 16

2007

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Abiraterone in “High-” and “Low-risk” Metastatic Hormone-sensitive Prostate Cancer

European urology, 2019-12, Vol.76 (6), p.719-728

2019

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Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial

The Lancet (British edition), 2011-12, Vol.378 (9809), p.2104-2111

2011

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Final Report of the Intergroup Randomized Study of Combined Androgen-Deprivation Therapy Plus Radiotherapy Versus Androgen-Deprivation Therapy Alone in Locally Advanced Prostate Cancer

Journal of clinical oncology, 2015-07, Vol.33 (19), p.2143-2150

2015

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Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy

JNCI : Journal of the National Cancer Institute, 2020-02, Vol.112 (2), p.179-190

2020

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Testing approaches to sharing trial results with participants: The Show RESPECT cluster randomised, factorial, mixed methods trial

PLoS medicine, 2021-10, Vol.18 (10), p.e1003798-e1003798

2021

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Dose–Volume Constraints to Reduce Rectal Side Effects From Prostate Radiotherapy: Evidence From MRC RT01 Trial ISRCTN 47772397

International journal of radiation oncology, biology, physics, 2010-03, Vol.76 (3), p.747-754

2010

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Reporting guidelines for clinical trials of artificial intelligence interventions: the SPIRIT-AI and CONSORT-AI guidelines

Trials, 2021-01, Vol.22 (1), p.11-11, Article 11

2021

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The SHOW RESPECT adaptable framework of considerations for planning how to share trial results with participants, based on qualitative findings from trial participants and site staff

Trials, 2024-07, Vol.25 (1), p.467-18, Article 467

2024

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Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials

The lancet oncology, 2009-09, Vol.10 (9), p.872-876

2009

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A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1

Nature genetics, 2014-08, Vol.46 (8), p.891-894

2014

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Clinical trial designs for rare diseases: Studies developed and discussed by the International Rare Cancers Initiative

European journal of cancer (1990), 2015-02, Vol.51 (3), p.271-281

2015

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Outcomes and endpoints in cancer trials: bridging the divide

The lancet oncology, 2015, Vol.16 (1), p.e43-e52

2015

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Uptake of the multi-arm multi-stage (MAMS) adaptive platform approach: a trial-registry review of late-phase randomised clinical trials

BMJ open, 2022-03, Vol.12 (3), p.e055615-e055615

2022

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Monitoring in practice - How are UK academic clinical trials monitored? A survey

Trials, 2020-01, Vol.21 (1), p.59-59, Article 59

2020

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Late Gastrointestinal Toxicity After Dose-Escalated Conformal Radiotherapy for Early Prostate Cancer: Results From the UK Medical Research Council RT01 Trial (ISRCTN47772397)

International journal of radiation oncology, biology, physics, 2010-07, Vol.77 (3), p.773-783

2010

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Prospective reporting of statistical analysis plans for randomised controlled trials

Trials, 2020-10, Vol.21 (1), p.898-898, Article 898

2020

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Adaptive designs in clinical trials: why use them, and how to run and report them

Prostate Radiotherapy for Metastatic Hormone-sensitive Prostate Cancer: A STOPCAP Systematic Review and Meta-analysis

Addition of docetaxel or bisphosphonates to standard of care in men with localised or metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

Practical methods for incorporating summary time-to-event data into meta-analysis

Medicines and Healthcare products Regulatory Agency's "Consultation on proposals for legislative changes for clinical trials": a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing

Abiraterone in “High-” and “Low-risk” Metastatic Hormone-sensitive Prostate Cancer

Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial

Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial

Final Report of the Intergroup Randomized Study of Combined Androgen-Deprivation Therapy Plus Radiotherapy Versus Androgen-Deprivation Therapy Alone in Locally Advanced Prostate Cancer

Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy

Testing approaches to sharing trial results with participants: The Show RESPECT cluster randomised, factorial, mixed methods trial

Dose–Volume Constraints to Reduce Rectal Side Effects From Prostate Radiotherapy: Evidence From MRC RT01 Trial ISRCTN 47772397

Reporting guidelines for clinical trials of artificial intelligence interventions: the SPIRIT-AI and CONSORT-AI guidelines

The SHOW RESPECT adaptable framework of considerations for planning how to share trial results with participants, based on qualitative findings from trial participants and site staff

Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials

A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1

Clinical trial designs for rare diseases: Studies developed and discussed by the International Rare Cancers Initiative

Outcomes and endpoints in cancer trials: bridging the divide

Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial

Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study

Uptake of the multi-arm multi-stage (MAMS) adaptive platform approach: a trial-registry review of late-phase randomised clinical trials

Monitoring in practice - How are UK academic clinical trials monitored? A survey

Realising the full potential of data-enabled trials in the UK: a call for action

Late Gastrointestinal Toxicity After Dose-Escalated Conformal Radiotherapy for Early Prostate Cancer: Results From the UK Medical Research Council RT01 Trial (ISRCTN47772397)

Prospective reporting of statistical analysis plans for randomised controlled trials

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