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Structure-based discovery of tipranavir disodium (PNU-140690E): A potent, orally bioavailable, nonpeptidic HIV protease inhibitor

BIOPOLYM, 1999, Vol.51 (1), p.51-58

1999

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CHAPTER 3 - Anti-Inflammatory Drugs

Pain therapeutics : current and future treatment paradigms, 2014, p.105-130

2014

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An Inhibitor of the Protease Blocks Maturation of Human and Simian Immunodeficiency Viruses and Spread of Infection

Proceedings of the National Academy of Sciences - PNAS, 1990-10, Vol.87 (19), p.7472-7476

1990

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Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors

Journal of medicinal chemistry, 1996-06, Vol.39 (12), p.2400-2410

1996

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Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

Journal of medicinal chemistry, 1995-09, Vol.38 (18), p.3624-3637

1995

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The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors

The Journal of biological chemistry, 1993-06, Vol.268 (18), p.13103-13109

1993

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Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones

Bioorganic & medicinal chemistry letters, 1998-05, Vol.8 (10), p.1237-1242

1998

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Discovery of indazoles as inhibitors of Tpl2 kinase

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (16), p.4758-4761

2011

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Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogs

Journal of medicinal chemistry, 1986-10, Vol.29 (10), p.2080-2087

1986

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An approach to the total synthesis of aplysiatoxin

Journal of the American Chemical Society, 1988-08, Vol.110 (17), p.5768-5779

1988

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Potential HIV protease inhibitors: Preparation of di- N-alkylated 2-, 6-, and 2,6-aminodeoxy-derivatives of d-glucose by direct displacement and by a novel reductive-alkylation procedure

Carbohydrate research, 1997-05, Vol.300 (2), p.109-117

1997

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The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (6), p.1994-2000

2010

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Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

Journal of medicinal chemistry, 1998-08, Vol.41 (18), p.3467-3476

1998

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Discovery of indazoles as inhibitors of Tp12 kinase

Bioorganic & medicinal chemistry letters, 2011, Vol.21 (16), p.4758-4761

2011

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Peptidomimetic HIV protease inhibitors: phosphate prodrugs with improved biological activities

Journal of medicinal chemistry, 1993-08, Vol.36 (17), p.2575-2577

1993

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The design and development of 2-aryl-2-hydroxy ethylamine substituted 1 H,7 H-pyrido[1,2,3- de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (6), p.1994-2000

2010

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Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo

Journal of medicinal chemistry, 1986-10, Vol.29 (10), p.2088-2093

1986

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Difluorostatine and difluorostatone containing peptides as potent and specific renin inhibitors

Journal of medicinal chemistry, 1985-11, Vol.28 (11), p.1553-1555

1985

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Total synthesis of (.+-.)-aphidicolin and (.+-.)-.beta.-chamigrene

Journal of organic chemistry, 1984-03, Vol.49 (6), p.1001-1013

1984

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Renin inhibitory peptides. A .beta.-aspartyl residue as a replacement for the histidyl residue at the P-2 site

Journal of medicinal chemistry, 1990-05, Vol.33 (5), p.1337-1343

1990

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Diastereoselective benzyloxymercuration/demercuration of derivatives of .gamma.-alkyl-.delta.-hydroxy-.alpha.,.beta.-unsaturated esters. A new strategy for the synthesis of aldol-type products

Journal of the American Chemical Society, 1983-11, Vol.105 (25), p.7407-7413

1983

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Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors

Journal of medicinal chemistry, 1996-10, Vol.39 (22), p.4349-4353

1996

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Effect of Point Mutations on the Kinetics and the Inhibition of Human Immunodeficiency Virus Type 1 Protease: Relationship to Drug Resistance

Biochemistry (Easton), 1995, Vol.34 (4), p.1143-1152

1995

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An efficient method for the preparation of furanoid and pyranoid glycals

Journal of organic chemistry, 1978-02, Vol.43 (4), p.786-787

1978

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Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors

Journal of medicinal chemistry, 1996-11, Vol.39 (23), p.4630-4642

1996

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Structure-based discovery of tipranavir disodium (PNU-140690E): A potent, orally bioavailable, nonpeptidic HIV protease inhibitor

CHAPTER 3 - Anti-Inflammatory Drugs

An Inhibitor of the Protease Blocks Maturation of Human and Simian Immunodeficiency Viruses and Spread of Infection

Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors

Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors

Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones

Discovery of indazoles as inhibitors of Tpl2 kinase

Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogs

An approach to the total synthesis of aplysiatoxin

Potential HIV protease inhibitors: Preparation of di- N-alkylated 2-, 6-, and 2,6-aminodeoxy-derivatives of d-glucose by direct displacement and by a novel reductive-alkylation procedure

The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase

Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

Discovery of indazoles as inhibitors of Tp12 kinase

Peptidomimetic HIV protease inhibitors: phosphate prodrugs with improved biological activities

The design and development of 2-aryl-2-hydroxy ethylamine substituted 1 H,7 H-pyrido[1,2,3- de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase

Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo

Difluorostatine and difluorostatone containing peptides as potent and specific renin inhibitors

Total synthesis of (.+-.)-aphidicolin and (.+-.)-.beta.-chamigrene

Renin inhibitory peptides. A .beta.-aspartyl residue as a replacement for the histidyl residue at the P-2 site

Diastereoselective benzyloxymercuration/demercuration of derivatives of .gamma.-alkyl-.delta.-hydroxy-.alpha.,.beta.-unsaturated esters. A new strategy for the synthesis of aldol-type products

Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors

Effect of Point Mutations on the Kinetics and the Inhibition of Human Immunodeficiency Virus Type 1 Protease: Relationship to Drug Resistance

An efficient method for the preparation of furanoid and pyranoid glycals

Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors

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