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Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Blood, 2013-04, Vol.121 (14), p.2659-2668

2013

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Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells

Frontiers in pharmacology, 2024-07, Vol.15, p.1396710

2024

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A natural genetic variant of granzyme B confers lethality to a common viral infection

PLoS pathogens, 2014-12, Vol.10 (12), p.e1004526-e1004526

2014

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Caspase Activation by Granzyme B Is Indirect, and Caspase Autoprocessing Requires the Release of Proapoptotic Mitochondrial Factors

Immunity (Cambridge, Mass.), 2003-03, Vol.18 (3), p.319-329

2003

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Beyond target cell death – Granzyme serine proteases in health and disease

Molecular aspects of medicine, 2022-12, Vol.88, p.101152-101152, Article 101152

2022

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Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity

Journal of medicinal chemistry, 2022-11, Vol.65 (21), p.14305-14325

2022

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The Drug Efflux Protein, P-Glycoprotein, Additionally Protects Drug-Resistant Tumor Cells from Multiple Forms of Caspase-Dependent Apoptosis

Proceedings of the National Academy of Sciences - PNAS, 1998-06, Vol.95 (12), p.7024-7029

1998

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A Central Role for Bid in Granzyme B-induced Apoptosis

The Journal of biological chemistry, 2005-02, Vol.280 (6), p.4476-4482

2005

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Unlocking the secrets of cytotoxic granule proteins

Journal of leukocyte biology, 2001-07, Vol.70 (1), p.18-29

2001

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Granzyme B–Mediated Death of Pancreatic β-Cells Requires the Proapoptotic BH3-Only Molecule Bid

Diabetes (New York, N.Y.), 2006-08, Vol.55 (8), p.2212-2219

2006

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Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1

Blood, 2022-03, Vol.139 (12), p.1833-1849

2022

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A novel role for granzymes in anti-tumor immunity

Oncoimmunology, 2012-03, Vol.1 (2), p.219-221

2012

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Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo

Current Opinion in Immunology, 2000-06, Vol.12 (3), p.323-329

2000

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Granzyme B: pro-apoptotic, antiviral and antitumor functions

Current opinion in immunology, 2003-10, Vol.15 (5), p.533-543

2003

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Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

The FEBS journal, 2016-03, Vol.283 (5), p.947-961

2016

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Antigen‐specific CD4+CD25+ T cells induced by locally expressed ICOS‐Ig: the role of Foxp3, Perforin, Granzyme B and IL‐10 ‐ an experimental study

Transplant international, 2019-11, Vol.32 (11), p.1203-1215

2019

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Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus

Biochimica et biophysica acta. Proteins and proteomics, 2020-09, Vol.1868 (9), p.140457-140457, Article 140457

2020

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Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

Science advances, 2022-09, Vol.8 (37), p.eabm9427-eabm9427

2022

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Cathepsin H Is an Additional Convertase of Pro-granzyme B

The Journal of biological chemistry, 2010-07, Vol.285 (27), p.20514-20519

2010

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The Histone Deacetylase Inhibitor and Chemotherapeutic Agent Suberoylanilide Hydroxamic Acid (SAHA) Induces a Cell-Death Pathway Characterized by Cleavage of Bid and Production of Reactive Oxygen Species

Proceedings of the National Academy of Sciences - PNAS, 2001-09, Vol.98 (19), p.10833-10838

2001

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Activated mouse B cells lack expression of granzyme B

The Journal of immunology (1950), 2012-04, Vol.188 (8), p.3886-3892

2012

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Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L

Immunology, 2010-10, Vol.131 (2), p.257-267

2010

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Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

Blood, 2007-08, Vol.110 (4), p.1184-1190

2007

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ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome

Cancer immunology research, 2020-08, Vol.8 (8), p.1085-1098

2020

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A colorimetric assay that specifically measures Granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl

Journal of visualized experiments, 2014-11 (93), p.e52419-e52419

2014

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Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells

A natural genetic variant of granzyme B confers lethality to a common viral infection

Caspase Activation by Granzyme B Is Indirect, and Caspase Autoprocessing Requires the Release of Proapoptotic Mitochondrial Factors

Beyond target cell death – Granzyme serine proteases in health and disease

Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity

The Drug Efflux Protein, P-Glycoprotein, Additionally Protects Drug-Resistant Tumor Cells from Multiple Forms of Caspase-Dependent Apoptosis

A Central Role for Bid in Granzyme B-induced Apoptosis

Unlocking the secrets of cytotoxic granule proteins

Granzyme B–Mediated Death of Pancreatic β-Cells Requires the Proapoptotic BH3-Only Molecule Bid

Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1

A novel role for granzymes in anti-tumor immunity

Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo

Granzyme B: pro-apoptotic, antiviral and antitumor functions

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

Antigen‐specific CD4+CD25+ T cells induced by locally expressed ICOS‐Ig: the role of Foxp3, Perforin, Granzyme B and IL‐10 ‐ an experimental study

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

Cathepsin H Is an Additional Convertase of Pro-granzyme B

The Histone Deacetylase Inhibitor and Chemotherapeutic Agent Suberoylanilide Hydroxamic Acid (SAHA) Induces a Cell-Death Pathway Characterized by Cleavage of Bid and Production of Reactive Oxygen Species

Activated mouse B cells lack expression of granzyme B

Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome

A colorimetric assay that specifically measures Granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl

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