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Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity and antimicrobial activity

Journal of medicinal chemistry, 1992-12, Vol.35 (25), p.4745-4750

1992

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2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3‘,5‘-bis(trifluoromethyl)phenyl)- carboxamide: A Potent Inhibitor of NF-κB- and AP-1-Mediated Gene Expression Identified Using Solution-Phase Combinatorial Chemistry

Journal of medicinal chemistry, 1998-02, Vol.41 (4), p.413-419

1998

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Inhibitors of NF-κB and AP-1 Gene Expression: SAR Studies on the Pyrimidine Portion of 2-Chloro-4-trifluoromethylpyrimidine-5-[N-(3‘,5‘-bis(trifluoromethyl)phenyl)carboxamide]

Journal of medicinal chemistry, 2000-10, Vol.43 (21), p.3995-4004

2000

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1,4-Dihydropyridine antagonist activities at the calcium channel: a quantitative structure-activity relationship approach

Journal of medicinal chemistry, 1988-11, Vol.31 (11), p.2103-2107

1988

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Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1-pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy

Journal of medicinal chemistry, 1993-04, Vol.36 (7), p.871-882

1993

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Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase

Anti-cancer drug design, 1991-05, Vol.6 (2), p.107

1991

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A novel inhibitor of nuclear factor-κB and activator protein-1 transcription factors in T cells suppresses host-versus-graft alloreactivity in vivo

Transplantation proceedings, 1997-02, Vol.29 (1), p.1269-1270

1997

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SP100030 is a novel T-cell-specific transcription factor inhibitor that possesses immunosuppressive activity in vivo

Transplantation proceedings, 1996-12, Vol.28 (6), p.3106-3109

1996

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Designing chiral libraries for drug discovery

Drug Discovery Today, 2000-08, Vol.5 (8), p.364-372

2000

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The biochemistry and pharmacology of PD 116124 (8-amino-2'-nordeoxyguanosine), an inhibitor of purine nucleoside phosphorylase (PNP)

The Journal of pharmacology and experimental therapeutics, 1992-01, Vol.260 (1), p.319

1992

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Synthesis and antibacterial activity of new quinolones containing a 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl] moiety. Gram-positive agents with excellent oral activity and low side-effect potential

Journal of medicinal chemistry, 1994-03, Vol.37 (6), p.733-738

1994

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Solution-phase parallel synthesis using ion-exchange resins

Tetrahedron, 1998-04, Vol.54 (16), p.4141-4150

1998

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Dual-function radiosensitizers. .alpha.-[[(2-Bromoethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanol and related compounds: preparation via an aziridine equivalent

Journal of medicinal chemistry, 1991-03, Vol.34 (3), p.1207-1209

1991

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A new class of analogues of the bifunctional radiosensitizer α-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069) : the cycloalkylaziridines

Journal of medicinal chemistry, 1991-08, Vol.34 (8), p.2484-2488

1991

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Synthesis and evaluation of .alpha.-[[(2-haloethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanols as prodrugs of .alpha.-[(1-aziridinyl)methyl]-2-nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogs which are radiosensitizers and bioreductively activated cytotoxins

Journal of medicinal chemistry, 1990-09, Vol.33 (9), p.2603-2610

1990

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N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy

ACS medicinal chemistry letters, 2011-06, Vol.2 (6), p.481-484

2011

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Ion-exchange resins for solution phase parallel synthesis of chemical libraries

Tetrahedron letters, 1997-01, Vol.38 (4), p.513-516

1997

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Stereoselective Michael additions of nitromethane yielding 3R(1S N-substituted aminoethyl)pyrrolidines

Tetrahedron letters, 1993-11, Vol.34 (47), p.7529-7532

1993

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Traceless linker: Oxidative activation and displacement of a sulfur-based linker

Tetrahedron letters, 1997-01, Vol.38 (2), p.211-214

1997

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A General and Regiospecific Synthesis of 5,8-Disubstituted α-Tetralones

Synthetic communications, 1998-09, Vol.28 (18), p.3491-3502

1998

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An efficient method for the synthesis of ( R)-3-(1-amino-1-methylethyl)pyrrolidines for the antiinfective agent, PD 138312

Tetrahedron: asymmetry, 1994-07, Vol.5 (7), p.1131-1134

1994

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8-Amino-9-substituted guanines: potent purine nucleoside phosphorylase (PNP) inhibitors

Agents and Actions, 1987-08, Vol.21 (3-4), p.253-256

1987

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Synthesis and evaluation of a series of 3,5-disubstituted benzisoxazole-4,7-diones. Potent radiosensitizers in vitro

Journal of medicinal chemistry, 1991-11, Vol.34 (11), p.3290-3294

1991

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Inhibitors of human purine nucleoside phosphorylase. Synthesis, purine nucleoside phosphorylase inhibition, and T-cell cytotoxicity of 2,5-diaminothiazolo[5,4-d]pyrimidin-7(6H)-one and 2,5-diaminothiazolo[4,5-d]pyrimidin-7(6H)-one. Two thio isosteres of 8-aminoguanine

Journal of medicinal chemistry, 1986-09, Vol.29 (9), p.1804-1806

1986

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Design of a gene family screening library targeting G-protein coupled receptors

Journal of molecular graphics & modelling, 2004-09, Vol.23 (1), p.15-21

2004

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Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity and antimicrobial activity

2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3‘,5‘-bis(trifluoromethyl)phenyl)- carboxamide: A Potent Inhibitor of NF-κB- and AP-1-Mediated Gene Expression Identified Using Solution-Phase Combinatorial Chemistry

Inhibitors of NF-κB and AP-1 Gene Expression: SAR Studies on the Pyrimidine Portion of 2-Chloro-4-trifluoromethylpyrimidine-5-[N-(3‘,5‘-bis(trifluoromethyl)phenyl)carboxamide]

1,4-Dihydropyridine antagonist activities at the calcium channel: a quantitative structure-activity relationship approach

Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1-pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy

Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase

A novel inhibitor of nuclear factor-κB and activator protein-1 transcription factors in T cells suppresses host-versus-graft alloreactivity in vivo

SP100030 is a novel T-cell-specific transcription factor inhibitor that possesses immunosuppressive activity in vivo

Designing chiral libraries for drug discovery

The biochemistry and pharmacology of PD 116124 (8-amino-2'-nordeoxyguanosine), an inhibitor of purine nucleoside phosphorylase (PNP)

Synthesis and antibacterial activity of new quinolones containing a 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl] moiety. Gram-positive agents with excellent oral activity and low side-effect potential

Solution-phase parallel synthesis using ion-exchange resins

Dual-function radiosensitizers. .alpha.-[[(2-Bromoethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanol and related compounds: preparation via an aziridine equivalent

A new class of analogues of the bifunctional radiosensitizer α-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069) : the cycloalkylaziridines

Synthesis and evaluation of .alpha.-[[(2-haloethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanols as prodrugs of .alpha.-[(1-aziridinyl)methyl]-2-nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogs which are radiosensitizers and bioreductively activated cytotoxins

N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy

Ion-exchange resins for solution phase parallel synthesis of chemical libraries

Stereoselective Michael additions of nitromethane yielding 3R(1S N-substituted aminoethyl)pyrrolidines

Traceless linker: Oxidative activation and displacement of a sulfur-based linker

A General and Regiospecific Synthesis of 5,8-Disubstituted α-Tetralones

An efficient method for the synthesis of ( R)-3-(1-amino-1-methylethyl)pyrrolidines for the antiinfective agent, PD 138312

8-Amino-9-substituted guanines: potent purine nucleoside phosphorylase (PNP) inhibitors

Synthesis and evaluation of a series of 3,5-disubstituted benzisoxazole-4,7-diones. Potent radiosensitizers in vitro

Inhibitors of human purine nucleoside phosphorylase. Synthesis, purine nucleoside phosphorylase inhibition, and T-cell cytotoxicity of 2,5-diaminothiazolo[5,4-d]pyrimidin-7(6H)-one and 2,5-diaminothiazolo[4,5-d]pyrimidin-7(6H)-one. Two thio isosteres of 8-aminoguanine

Design of a gene family screening library targeting G-protein coupled receptors

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