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Mexiletine Block of Voltage-Gated Sodium Channels: Isoform- and State-Dependent Drug-Pore Interactions

Molecular pharmacology, 2019-03, Vol.95 (3), p.236-244

2019

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Drug-Binding Sites of Cardiac Sodium Channel

Journal of arrhythmia, 2011, Vol.27 (Supplement), p.SS1_2

Sunami, Akihiko

2011

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Electrophysiological effects of ginseng and ginsenoside Re in guinea pig ventricular myocytes

European journal of pharmacology, 2003-08, Vol.476 (1), p.35-44

2003

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Sodium Channel Selectivity Filter Regulates Antiarrhythmic Drug Binding

Proceedings of the National Academy of Sciences - PNAS, 1997-12, Vol.94 (25), p.14126-14131

1997

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Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents

The Journal of physiology, 2004-12, Vol.561 (2), p.403-413

2004

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A Critical Residue for Isoform Difference in Tetrodotoxin Affinity Is a Molecular Determinant of the External Access Path for Local Anesthetics in the Cardiac Sodium Channel

Proceedings of the National Academy of Sciences - PNAS, 2000-02, Vol.97 (5), p.2326-2331

2000

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Unexpected Mexiletine Responses of a Mutant Cardiac Na+ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

Molecular pharmacology, 2004-08, Vol.66 (2), p.330-336

2004

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Structural and Gating Changes of the Sodium Channel Induced by Mutation of a Residue in the Upper Third of IVS6, Creating an External Access Path for Local Anesthetics

Molecular pharmacology, 2001-04, Vol.59 (4), p.684-691

2001

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The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome

The Journal of clinical investigation, 2008-06, Vol.118 (6), p.2219-2229

2008

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SS1-2 Drug-Binding Sites of Cardiac Sodium Channel

Journal of Arrhythmia, 2011-09, Vol.27 (suppl), p.241-241

Akihiko Sunami

2011

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P3L-19 Single channel study of ranolazine block late sodium currents in guinea pig ventricular myocytes

Journal of Pharmacological Sciences, 2008, Vol.106 (suppl.2), p.265-265

Akihiko Sunami

2008

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A Genetically Encoded Bioluminescent Indicator for the Sodium Channel Activity in Living Cells

Journal of the American Chemical Society, 2009-04, Vol.131 (12), p.4188-4189

2009

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P2-094 Functional characterization of SCN5A mutation, F1293S, associated with Brugada syndrome

Journal of Pharmacological Sciences, 2007, Vol.103 (suppl.2), p.196-196

2007

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Role of L1462 in Nav1.5 Channel DIII-S6 in Voltage-dependent Gating and Antiarrhythmic Block

Biophysical journal, 2009-02, Vol.96 (3), p.250a-250a

2009

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P3J-16-1 Role of N406 in Nav1.5 channel DI-S6 in voltage-dependent gating and antiarrhythmic block

Journal of Pharmacological Sciences, 2010, Vol.112 (suppl), p.249-249

2010

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P1N-P9-1 Role of L1462 in Nav1.5 channel DIII-S6 in voltage-dependent gating and antiarrhythmic block

Journal of Pharmacological Sciences, 2009, Vol.109 (suppl.2), p.168-168

2009

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Local Anesthetics

Encyclopedia of Molecular Pharmacology, 2021, p.936-941

2021

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Involvement of local anesthetic binding sites on IVS6 of sodium channels in fast and slow inactivation

Neuroscience letters, 2003-01, Vol.337 (1), p.41-45

2003

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Cardiac-Specific External Paths for Lidocaine, Defined by Isoform-Specific Residues, Accelerate Recovery From Use-Dependent Block

Circulation research, 2001-11, Vol.89 (11), p.1014-1021

2001

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New observations on the mechanisms of antiarrhythmic actions of disopyramide on cardiac membranes

The American journal of cardiology, 1989-12, Vol.64 (20), p.J15-J19

1989

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Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na super(+) channel to methanethiosulfonate reagents

The Journal of physiology, 2004-12, Vol.561 (2), p.403-413

2004

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Electrophysiological properties of a new antiarrhythmic agent, bisaramil on guinea-pig, rabbit and canine cardiac preparations

Naunyn-Schmiedeberg's archives of pharmacology, 1991-09, Vol.344 (3), p.323-330

1991

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Synthesis and Biological Activity of the Metabolites of syn-3-Ethyl-7-methyl-3, 7-diazabicyclo[3.3.1]non-9-yl 4-Chlorobenzoate Hydrochloride

Chemical and Pharmaceutical Bulletin, 1994/11/15, Vol.42(11), pp.2365-2369

1994

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Combined effects of different class I antiarrhythmic agents on maximum rate of depolarization (V max ) of action potentials in guinea-gig papillary muscles

Cardiovascular drugs and therapy, 1991-08, Vol.5 (S4), p.791-799, Article 791

1991

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Blockade of cardiac Na + channels by a charged class I antiarrhythmic agent, bisaramil: possible interaction of the drug with a pre-open closed state

European journal of pharmacology, 1996-09, Vol.312 (2), p.245-255

1996

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Mexiletine Block of Voltage-Gated Sodium Channels: Isoform- and State-Dependent Drug-Pore Interactions

Drug-Binding Sites of Cardiac Sodium Channel

Electrophysiological effects of ginseng and ginsenoside Re in guinea pig ventricular myocytes

Sodium Channel Selectivity Filter Regulates Antiarrhythmic Drug Binding

Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents

A Critical Residue for Isoform Difference in Tetrodotoxin Affinity Is a Molecular Determinant of the External Access Path for Local Anesthetics in the Cardiac Sodium Channel

Unexpected Mexiletine Responses of a Mutant Cardiac Na+ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

Structural and Gating Changes of the Sodium Channel Induced by Mutation of a Residue in the Upper Third of IVS6, Creating an External Access Path for Local Anesthetics

The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome

SS1-2 Drug-Binding Sites of Cardiac Sodium Channel

P3L-19 Single channel study of ranolazine block late sodium currents in guinea pig ventricular myocytes

A Genetically Encoded Bioluminescent Indicator for the Sodium Channel Activity in Living Cells

P2-094 Functional characterization of SCN5A mutation, F1293S, associated with Brugada syndrome

Role of L1462 in Nav1.5 Channel DIII-S6 in Voltage-dependent Gating and Antiarrhythmic Block

P3J-16-1 Role of N406 in Nav1.5 channel DI-S6 in voltage-dependent gating and antiarrhythmic block

P1N-P9-1 Role of L1462 in Nav1.5 channel DIII-S6 in voltage-dependent gating and antiarrhythmic block

Local Anesthetics

Involvement of local anesthetic binding sites on IVS6 of sodium channels in fast and slow inactivation

Cardiac-Specific External Paths for Lidocaine, Defined by Isoform-Specific Residues, Accelerate Recovery From Use-Dependent Block

New observations on the mechanisms of antiarrhythmic actions of disopyramide on cardiac membranes

Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na super(+) channel to methanethiosulfonate reagents

Electrophysiological properties of a new antiarrhythmic agent, bisaramil on guinea-pig, rabbit and canine cardiac preparations

Synthesis and Biological Activity of the Metabolites of syn-3-Ethyl-7-methyl-3, 7-diazabicyclo[3.3.1]non-9-yl 4-Chlorobenzoate Hydrochloride

Combined effects of different class I antiarrhythmic agents on maximum rate of depolarization (V max ) of action potentials in guinea-gig papillary muscles

Blockade of cardiac Na + channels by a charged class I antiarrhythmic agent, bisaramil: possible interaction of the drug with a pre-open closed state

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