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The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor

ACS medicinal chemistry letters, 2010-07, Vol.1 (4), p.170-174

2010

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The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐ α and leukotriene B 4 in a novel human whole blood assay

British journal of pharmacology, 2009-01, Vol.126 (4), p.979-988

2009

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Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1201-1203

2004

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Synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid by human monocytes and lymphocytes

Journal of leukocyte biology, 1996-06, Vol.59 (6), p.847-854

1996

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Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6387-6393

2010

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Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7281-7286

2011

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A Multiplexed Cell Assay in HepG2 Cells for the Identification of Delta-5, Delta-6, and Delta-9 Desaturase and Elongase Inhibitors

Journal of biomolecular screening, 2010-02, Vol.15 (2), p.169-176

2010

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Optimization and structure–activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: Identification of MK-0873, a potent and effective PDE4 inhibitor

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5554-5558

2008

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Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (4), p.1407-1412

2008

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The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐α and leukotriene B4 in a novel human whole blood assay

British journal of pharmacology, 1999-02, Vol.126 (4), p.979-988

1999

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Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5266-5269

2009

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In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)

Bioorganic & medicinal chemistry letters, 2001-04, Vol.11 (8), p.1059-1062

2001

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Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2608-2612

2006

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Substituted 2-Pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (11), p.1923-1926

2003

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Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (4), p.741-744

2003

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Proliferative response of airway smooth muscle cells to macrophage-derived products

Styhler, Angela

1995

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Mechanical Responses of Tracheal Tissue In Vitro: Dependance on the Tissue Preparation Employed and Relationship to Smooth Muscle Content

Pulmonary pharmacology (Edinburgh), 1996-06, Vol.9 (3), p.157-166

1996

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Increased maximal pulmonary response to methacholine and airway smooth muscle in immature compared with mature rabbits

American journal of respiratory and critical care medicine, 1995-03, Vol.151 (3 Pt 1), p.836

1995

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Antiproliferative effect of prostaglandin E(2) in cultured guinea pig tracheal smooth muscle cells

American journal of physiology. Lung cellular and molecular physiology, 1994-02, Vol.10 (2), p.L131

1994

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Evaluation of Loxoprofen and Its Alcohol Metabolites for Potency and Selectivity of Inhibition of Cyclooxygenase-2

ChemInform, 2004-06, Vol.35 (23), p.no-no

2004

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Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia

The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor

The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐ α and leukotriene B 4 in a novel human whole blood assay

Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2

Synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid by human monocytes and lymphocytes

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment

Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

A Multiplexed Cell Assay in HepG2 Cells for the Identification of Delta-5, Delta-6, and Delta-9 Desaturase and Elongase Inhibitors

Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Optimization and structure–activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: Identification of MK-0873, a potent and effective PDE4 inhibitor

Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors

The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐α and leukotriene B4 in a novel human whole blood assay

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors

In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)

Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors

Substituted 2-Pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors

Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors

Discovery of a substituted 8-arylquinoline series of PED4 inhibitors : Structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

Proliferative response of airway smooth muscle cells to macrophage-derived products

Mechanical Responses of Tracheal Tissue In Vitro: Dependance on the Tissue Preparation Employed and Relationship to Smooth Muscle Content

Increased maximal pulmonary response to methacholine and airway smooth muscle in immature compared with mature rabbits

Antiproliferative effect of prostaglandin E(2) in cultured guinea pig tracheal smooth muscle cells

Evaluation of Loxoprofen and Its Alcohol Metabolites for Potency and Selectivity of Inhibition of Cyclooxygenase-2

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