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Randomized controlled trial of intraoperative goal-directed fluid therapy in aerobically fit and unfit patients having major colorectal surgery

British journal of anaesthesia : BJA, 2012-01, Vol.108 (1), p.53-62

2012

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Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers

Pituitary, 2022-04, Vol.25 (2), p.328-339

2022

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Discovery of nonpeptide 3,4-dihydroquinazoline-4-carboxamides as potent and selective sst2 agonists

Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (17), p.127391-127391, Article 127391

2020

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Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism

Bioorganic & medicinal chemistry letters, 2022-09, Vol.71, p.128807-128807, Article 128807

2022

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Differential Desensitization, Receptor Phosphorylation, β-Arrestin Recruitment, and ERK1/2 Activation by the Two Endogenous Ligands for the CC Chemokine Receptor 7

The Journal of biological chemistry, 2004-05, Vol.279 (22), p.23214-23222

2004

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Validation of preoperative cardiopulmonary exercise testing-derived variables to predict in-hospital morbidity after major colorectal surgery

British journal of surgery, 2016-05, Vol.103 (6), p.744-752

2016

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ACROBAT Edge: Safety and Efficacy of Switching Injected SRLs to Oral Paltusotine in Patients With Acromegaly

The journal of clinical endocrinology and metabolism, 2023-05, Vol.108 (5), p.e148-e159

2023

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Stroke volume optimisation: is the fairy tale over?

Anaesthesia, 2014-04, Vol.69 (4), p.291-296

2014

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It's not about the bike: enhancing oxygen delivery

British journal of anaesthesia : BJA, 2017-05, Vol.118 (5), p.655-657

2017

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Acromegaly Disease Control Maintained After Switching From Injected Somatostatin Receptor Ligands to Oral Paltusotine

The journal of clinical endocrinology and metabolism, 2024-06

2024

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In Vitro Pharmacological Characterization of CRN04894: The First Reported Oral, Selective Nonpeptide Melanocortin 2 Receptor Antagonist Evaluated in Phase 1 First‐in‐Human Clinical Trials

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (21), p.127496-127496, Article 127496

2020

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Patients’ inability to perform a preoperative cardiopulmonary exercise test or demonstrate an anaerobic threshold is associated with inferior outcomes after major colorectal surgery

British journal of anaesthesia : BJA, 2013-10, Vol.111 (4), p.607-611

2013

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Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist Elagolix

The journal of clinical endocrinology and metabolism, 2009-02, Vol.94 (2), p.545-551

2009

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Randomized controlled trial of stroke volume optimization during elective major abdominal surgery in patients stratified by aerobic fitness

British journal of anaesthesia : BJA, 2015-10, Vol.115 (4), p.578-589

2015

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Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist

ACS medicinal chemistry letters, 2023-01, Vol.14 (1), p.66-74

2023

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Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist

ACS medicinal chemistry letters, 2024-04, Vol.15 (4), p.478-485

2024

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Reproductive physiology of a humanized GnRH receptor mouse model: application in evaluation of human-specific analogs

American journal of physiology: endocrinology and metabolism, 2013-07, Vol.305 (1), p.E67-E77

2013

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Assessing fitness for surgery: a comparison of questionnaire, incremental shuttle walk, and cardiopulmonary exercise testing in general surgical patients

British journal of anaesthesia : BJA, 2008-12, Vol.101 (6), p.774-780

2008

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Gonadotropin‐Releasing Hormone Targeting for Gonadotroph Ablation: An Approach to Non‐surgical Sterilization

Reproduction in domestic animals, 2012-08, Vol.47 (s4), p.233-238

Struthers, RS

2012

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Oesophageal Doppler monitoring: costly and supported by weak evidence

Anaesthesia, 2012-04, Vol.67 (4), p.426-427

2012

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Discovery of Sodium R-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

Journal of medicinal chemistry, 2008-12, Vol.51 (23), p.7478-7485

2008

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Non-Peptide Gonadotropin-Releasing Hormone Receptor Antagonists

Journal of medicinal chemistry, 2008-06, Vol.51 (12), p.3331-3348

2008

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Distinct Conformations of the Corticotropin Releasing Factor Type 1 Receptor Adopted following Agonist and Antagonist Binding Are Differentially Regulated

The Journal of biological chemistry, 2005-03, Vol.280 (12), p.11560-11568

2005

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Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (19), p.4363-4366

2005

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Randomized controlled trial of intraoperative goal-directed fluid therapy in aerobically fit and unfit patients having major colorectal surgery

Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers

Discovery of nonpeptide 3,4-dihydroquinazoline-4-carboxamides as potent and selective sst2 agonists

Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism

Differential Desensitization, Receptor Phosphorylation, β-Arrestin Recruitment, and ERK1/2 Activation by the Two Endogenous Ligands for the CC Chemokine Receptor 7

Validation of preoperative cardiopulmonary exercise testing-derived variables to predict in-hospital morbidity after major colorectal surgery

ACROBAT Edge: Safety and Efficacy of Switching Injected SRLs to Oral Paltusotine in Patients With Acromegaly

Stroke volume optimisation: is the fairy tale over?

It's not about the bike: enhancing oxygen delivery

Acromegaly Disease Control Maintained After Switching From Injected Somatostatin Receptor Ligands to Oral Paltusotine

In Vitro Pharmacological Characterization of CRN04894: The First Reported Oral, Selective Nonpeptide Melanocortin 2 Receptor Antagonist Evaluated in Phase 1 First‐in‐Human Clinical Trials

Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist

Patients’ inability to perform a preoperative cardiopulmonary exercise test or demonstrate an anaerobic threshold is associated with inferior outcomes after major colorectal surgery

Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist Elagolix

Randomized controlled trial of stroke volume optimization during elective major abdominal surgery in patients stratified by aerobic fitness

Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist

Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist

Reproductive physiology of a humanized GnRH receptor mouse model: application in evaluation of human-specific analogs

Assessing fitness for surgery: a comparison of questionnaire, incremental shuttle walk, and cardiopulmonary exercise testing in general surgical patients

Gonadotropin‐Releasing Hormone Targeting for Gonadotroph Ablation: An Approach to Non‐surgical Sterilization

Oesophageal Doppler monitoring: costly and supported by weak evidence

Discovery of Sodium R-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

Non-Peptide Gonadotropin-Releasing Hormone Receptor Antagonists

Distinct Conformations of the Corticotropin Releasing Factor Type 1 Receptor Adopted following Agonist and Antagonist Binding Are Differentially Regulated

Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor

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