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Exploratory translational modeling approach in drug development to predict human brain pharmacokinetics and pharmacologically relevant clinical doses

Drug metabolism and disposition, 2012-05, Vol.40 (5), p.877-883

2012

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Development of a Rat Plasma and Brain Extracellular Fluid Pharmacokinetic Model for Bupropion and Hydroxybupropion Based on Microdialysis Sampling, and Application to Predict Human Brain Concentrations

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.624-633

2016

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Mechanism and kinetics of transcellular transport of a new β-lactam antibiotic loracarbef across an intestinal epithelial membrane model system (Caco-2)

Pharmaceutical research, 1994-10, Vol.11 (10), p.1405-1413

1994

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Activities of the semisynthetic glycopeptide LY191145 against vancomycin-resistant enterococci and other gram-positive bacteria

Antimicrobial Agents and Chemotherapy, 1995-11, Vol.39 (11), p.2585-2587

1995

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Mechanisms of transport of quinapril in Caco-2 cell monolayers : comparison with cephalexin

Pharmaceutical research, 1995-08, Vol.12 (8), p.1120-1125

1995

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Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication

Journal of pharmaceutical sciences, 1999-08, Vol.88 (8), p.747-753

1999

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Regional‐Dependent Intestinal Absorption and Meal Composition Effects on Systemic Availability of LY303366, a Lipopeptide Antifungal Agent, in Dogs

Journal of pharmaceutical sciences, 2001-01, Vol.90 (1), p.47-57

2001

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Uptake Characteristics of Loracarbef and Cephalexin in the Caco-2 Cell Culture Model: Effects of the Proton Gradient and Possible Presence of a Distinctive Second Component

Journal of pharmaceutical sciences, 1996-07, Vol.85 (7), p.767-772

1996

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Peptide Transporter Function and Prolidase Activities in Caco-2 Cells: A Lack of Coordinated Expression

Journal of drug targeting, 1995, Vol.3 (4), p.291-300

1995

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Regional‐dependent intestinal absorption and meal composition effects on systemic availability of LY303366, a lipopeptide antifungal agent, in dogs

Journal of pharmaceutical sciences, 2001-01, Vol.90 (1), p.47-57

2001

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Aminopeptidase Activity in Albino Rabbit Extraocular Tissues Relative to the Small Intestine

Journal of pharmaceutical sciences, 1985-07, Vol.74 (7), p.731-734

1985

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Ocular aminopeptidase activity and distribution in the albino rabbit

Current eye research, 1985-01, Vol.4 (9), p.995-1000

1985

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Three-Dimensional Quantitative Structure-Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus Replication

Journal of Chemical Information and Computer Sciences, 2001-11, Vol.41 (6), p.1578-1586

2001

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Systemic Absorption of Ocularly Administered Enkephalinamide and Inulin in the Albino Rabbit: Extent, Pathways, and Vehicle Effects

Journal of pharmaceutical sciences, 1988-10, Vol.77 (10), p.838-842

1988

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Disposition of topically applied sodium cromoglycate in the albino rabbit eye

Journal of pharmacy and pharmacology, 1983-07, Vol.35 (7), p.445-450

1983

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In vitro measurement of drug transport using a new diffusion chamber compatible with Millicell® culture supports: Performance with caco-2 monolayers

International journal of pharmaceutics, 1996-05, Vol.133 (1), p.47-58

1996

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Development of a plasma high-performance liquid chromatographic assay for LY303366, a lipopeptide antifungal agent, and its application in a dog pharmacokinetic study

Journal of chromatography. B, Biomedical sciences and applications, 1997-08, Vol.695 (2), p.381-387

1997

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Dipeptides as Effective Prodrugs of the Unnatural Amino Acid (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740), a Selective Group II Metabotropic Glutamate Receptor Agonist

Journal of medicinal chemistry, 2005-08, Vol.48 (16), p.5305-5320

2005

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Esterase distribution in the rabbit cornea and its implications in ocular drug bioavailability

Biopharmaceutics & drug disposition, 1982-10, Vol.3 (4), p.291-300

1982

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Two Prodrugs of Potent and Selective GluR5 Kainate Receptor Antagonists Actives in Three Animal Models of Pain

Journal of medicinal chemistry, 2005-06, Vol.48 (13), p.4200-4203

2005

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Ocular distribution of liposome-encapsulated epinephrine and inulin in the albino rabbit

Current eye research, 1982, Vol.2 (6), p.377-386

1982

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Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester: A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

Journal of medicinal chemistry, 2002-09, Vol.45 (20), p.4383-4386

2002

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Metabolic and permeation barriers to the ocular absorption of topically applied enkephalins in albino rabbits

Journal of ocular pharmacology, 1986, Vol.2 (4), p.345-352

1986

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A novel response to propranolol: Contractile response in the isolated rabbit ear artery

Life sciences (1973), 1980-01, Vol.26 (2), p.155-163

1980

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Aminopeptidase activity in homogenates of various absorptive mucosae in the abbino rabbit: implications in peptide delivery

International journal of pharmaceutics, 1986, Vol.30 (1), p.73-82

1986

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Exploratory translational modeling approach in drug development to predict human brain pharmacokinetics and pharmacologically relevant clinical doses

Development of a Rat Plasma and Brain Extracellular Fluid Pharmacokinetic Model for Bupropion and Hydroxybupropion Based on Microdialysis Sampling, and Application to Predict Human Brain Concentrations

Mechanism and kinetics of transcellular transport of a new β-lactam antibiotic loracarbef across an intestinal epithelial membrane model system (Caco-2)

Activities of the semisynthetic glycopeptide LY191145 against vancomycin-resistant enterococci and other gram-positive bacteria

Mechanisms of transport of quinapril in Caco-2 cell monolayers : comparison with cephalexin

Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication

Regional‐Dependent Intestinal Absorption and Meal Composition Effects on Systemic Availability of LY303366, a Lipopeptide Antifungal Agent, in Dogs

Uptake Characteristics of Loracarbef and Cephalexin in the Caco-2 Cell Culture Model: Effects of the Proton Gradient and Possible Presence of a Distinctive Second Component

Peptide Transporter Function and Prolidase Activities in Caco-2 Cells: A Lack of Coordinated Expression

Regional‐dependent intestinal absorption and meal composition effects on systemic availability of LY303366, a lipopeptide antifungal agent, in dogs

Aminopeptidase Activity in Albino Rabbit Extraocular Tissues Relative to the Small Intestine

Ocular aminopeptidase activity and distribution in the albino rabbit

Three-Dimensional Quantitative Structure-Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus Replication

Systemic Absorption of Ocularly Administered Enkephalinamide and Inulin in the Albino Rabbit: Extent, Pathways, and Vehicle Effects

Disposition of topically applied sodium cromoglycate in the albino rabbit eye

In vitro measurement of drug transport using a new diffusion chamber compatible with Millicell® culture supports: Performance with caco-2 monolayers

Development of a plasma high-performance liquid chromatographic assay for LY303366, a lipopeptide antifungal agent, and its application in a dog pharmacokinetic study

Dipeptides as Effective Prodrugs of the Unnatural Amino Acid (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740), a Selective Group II Metabotropic Glutamate Receptor Agonist

Esterase distribution in the rabbit cornea and its implications in ocular drug bioavailability

Two Prodrugs of Potent and Selective GluR5 Kainate Receptor Antagonists Actives in Three Animal Models of Pain

Ocular distribution of liposome-encapsulated epinephrine and inulin in the albino rabbit

Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester: A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

Metabolic and permeation barriers to the ocular absorption of topically applied enkephalins in albino rabbits

A novel response to propranolol: Contractile response in the isolated rabbit ear artery

Aminopeptidase activity in homogenates of various absorptive mucosae in the abbino rabbit: implications in peptide delivery

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