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Growth‐rate model predicts in vivo tumor response from in vitro data

CPT: pharmacometrics and systems pharmacology, 2022-09, Vol.11 (9), p.1183-1193

2022

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ER+, HER2- advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes

Molecular oncology, 2023-10, Vol.17 (10), p.2000-2016

2023

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Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2-, PIK3CA-mutated breast cancers

Genome medicine, 2023-04, Vol.15 (1), p.28-28, Article 28

2023

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Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

Cancer research (Chicago, Ill.), 2006-12, Vol.66 (23), p.11100-11105

2006

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Discovery of XL413, a potent and selective CDC7 inhibitor

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (11), p.3727-3731

2012

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The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (15), p.4979-4985

2012

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Phase II Study of Taselisib (GDC-0032) in Combination with Fulvestrant in Patients with HER2-Negative, Hormone Receptor-Positive Advanced Breast Cancer

Clinical cancer research, 2018-09, Vol.24 (18), p.4380-4387

2018

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Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer (LORELEI): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

The lancet oncology, 2019-09, Vol.20 (9), p.1226-1238

2019

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Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.44039-44045

2004

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Structures of Active and Latent PAI-1: A Possible Stabilizing Role for Chloride Ions

Biochemistry (Easton), 2000-07, Vol.39 (29), p.8460-8469

2000

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The additivity of substrate fragments in enzyme–ligand binding

Structure (London), 1998-07, Vol.6 (7), p.839-848

1998

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Total synthesis of the macrolide antibiotic cytovaricin

Journal of the American Chemical Society, 1990-09, Vol.112 (19), p.7001-7031

1990

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The design, synthesis, and biological evaluation of PIM kinase inhibitors

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (11), p.3732-3738

2012

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D221 in Thymidylate Synthase Controls Conformation Change, and Thereby Opening of the Imidazolidine

Biochemistry (Easton), 1998-09, Vol.37 (39), p.13893-13901

1998

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Octalactins A and B: cytotoxic eight-membered-ring lactones from a marine bacterium, Streptomyces sp

Journal of the American Chemical Society, 1991-06, Vol.113 (12), p.4682-4683

1991

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An Essential Role for Water in an Enzyme Reaction Mechanism: The Crystal Structure of the Thymidylate Synthase Mutant E58Q

Biochemistry (Easton), 1996-12, Vol.35 (50), p.16270-16281

1996

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Vinylogous polypeptides: an alternative peptide backbone

Journal of the American Chemical Society, 1992-07, Vol.114 (16), p.6568-6570

1992

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Abstract OT-36-01: Phase III study of GDC-0077 or placebo (pbo) with palbociclib (P) + fulvestrant (F) in patients with PIK3CA -mutant/hormone receptor-positive/HER2-negative locally advanced or metastatic breast cancer (HR+/HER2- LA/MBC)

Cancer research (Chicago, Ill.), 2021-02, Vol.81 (4_Supplement), p.OT-36-01-OT-36-01

2021

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Studies on the solution- and solid-state structure of patellin 2

Journal of the American Chemical Society, 1990-10, Vol.112 (22), p.8080-8084

1990

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Can Mosquitoes Be Bitten? A New Hope for Anti-Malarial Drug Design

Structure, 2003-11, Vol.11 (11), p.1309-1310

2003

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The baconipyrones. Novel polypropionates from the pulmonate Siphonaria baconi

Journal of organic chemistry, 1989-10, Vol.54 (22), p.5371-5374

1989

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Structure-Based Design of Inhibitors Specific for Bacterial Thymidylate Synthase

Biochemistry (Easton), 1999-02, Vol.38 (5), p.1607-1617

1999

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Transannular Diels-Alder route to systems related to dynemicin A

Journal of the American Chemical Society, 1990-09, Vol.112 (20), p.7410-7411

1990

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Abstract 5165: The genomic landscape and prognostic implications of somatic alterations in patients (pts) with ER+, HER2-, PIK3CA mutated (mut) advanced breast cancer treated with taselisib and fulvestrant

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.5165-5165

2022

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Synthesis of the angular anthraquinone subunit of dynemicin A

Journal of organic chemistry, 1991-03, Vol.56 (5), p.1692-1694

1991

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Growth‐rate model predicts in vivo tumor response from in vitro data

ER+, HER2- advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes

Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2-, PIK3CA-mutated breast cancers

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

Discovery of XL413, a potent and selective CDC7 inhibitor

The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors

Phase II Study of Taselisib (GDC-0032) in Combination with Fulvestrant in Patients with HER2-Negative, Hormone Receptor-Positive Advanced Breast Cancer

Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer (LORELEI): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1

Structures of Active and Latent PAI-1: A Possible Stabilizing Role for Chloride Ions

The additivity of substrate fragments in enzyme–ligand binding

Total synthesis of the macrolide antibiotic cytovaricin

The design, synthesis, and biological evaluation of PIM kinase inhibitors

D221 in Thymidylate Synthase Controls Conformation Change, and Thereby Opening of the Imidazolidine

Octalactins A and B: cytotoxic eight-membered-ring lactones from a marine bacterium, Streptomyces sp

An Essential Role for Water in an Enzyme Reaction Mechanism: The Crystal Structure of the Thymidylate Synthase Mutant E58Q

Vinylogous polypeptides: an alternative peptide backbone

Abstract OT-36-01: Phase III study of GDC-0077 or placebo (pbo) with palbociclib (P) + fulvestrant (F) in patients with PIK3CA -mutant/hormone receptor-positive/HER2-negative locally advanced or metastatic breast cancer (HR+/HER2- LA/MBC)

Studies on the solution- and solid-state structure of patellin 2

Can Mosquitoes Be Bitten? A New Hope for Anti-Malarial Drug Design

The baconipyrones. Novel polypropionates from the pulmonate Siphonaria baconi

Structure-Based Design of Inhibitors Specific for Bacterial Thymidylate Synthase

Transannular Diels-Alder route to systems related to dynemicin A

Abstract 5165: The genomic landscape and prognostic implications of somatic alterations in patients (pts) with ER+, HER2-, PIK3CA mutated (mut) advanced breast cancer treated with taselisib and fulvestrant

Synthesis of the angular anthraquinone subunit of dynemicin A

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