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p53 +/- Hemizygous Knockout Mouse: Overview of Available Data

Toxicologic pathology, 2001, Vol.29 (1_suppl), p.30-50

2001

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The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens

Toxicologic pathology, 2001, Vol.29, p.24-29

2001

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Extent and Persistence of Streptozotocin-Induced DNA Damage and Cell Proliferation in Rat Kidney as Determined by in Vivo Alkaline Elution and BrdUrd Labeling Assays

Toxicology and applied pharmacology, 1995-12, Vol.135 (2), p.279-286

1995

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Transgenic tumor models for carcinogen identification: the heterozygous Trp53-deficient and RasH2 mouse lines

Mutation research, 2003-10, Vol.540 (2), p.165-176

2003

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Experimental Metastasis in Nude Mice of NIH 3T3 Cells Containing Various ras Genes

Proceedings of the National Academy of Sciences - PNAS, 1986-07, Vol.83 (14), p.5277-5281

1986

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Short-term carcinogenesis bioassay of genotoxic procarcinogens in PIM® transgenic mice

Carcinogenesis (New York), 1995-02, Vol.16 (2), p.285-293

1995

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Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors

Carcinogenesis (New York), 1994-11, Vol.15 (11), p.2665-2667

1994

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Rapid induction of hyperplasia in vitro in rat bladder explants by elevated sodium ion concentrations and alkaline pH

Toxicology and applied pharmacology, 1996-06, Vol.138 (2), p.219-230

1996

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Current status and use of short/medium term models for carcinogenicity testing of pharmaceuticals — scientific perspective

Toxicology letters, 2000-03, Vol.112 (1-3), p.557-566

2000

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Rapid DNA degradation in primary rat hepatocytes treated with diverse cytotoxic chemicals: Analysis by pulsed field gel electrophoresis and implications for alkaline elution assays

Environmental and molecular mutagenesis, 1994, Vol.24 (3), p.181-191

1994

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Occupational Hazard Evaluation of P-Bromobenzyl Bromide from Tests for Genotoxicity

Drug and chemical toxicology (New York, N.Y. 1978), 1999-01, Vol.22 (4), p.583-593

1999

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Genotoxicity of naturally occurring indole compounds: correlation between covalent DNA binding and other genotoxicity tests

Environmental and molecular mutagenesis, 2002, Vol.40 (1), p.1-17

2002

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Rapid induction of an experimental metastatic phenotype in first passage rat embryo cells by cotransfection of EJ c-Ha-ras and c-myc oncogenes

Oncogene, 1988-02, Vol.2 (2), p.141-147

1988

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Murine p53 intron sequences 5-8 and their use in polymerase chain reaction/direct sequencing analysis of p53 mutations in CD-1 mouse liver and lung tumors

Molecular carcinogenesis, 1992, Vol.5 (1), p.9-15

1992

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The effect of deuterium labeling on the genotoxicity of N-nitrosodimethylamine, epichlorohydrin and dimethyl sulfate

Mutation research, 1991-05, Vol.263 (1), p.9-12

1991

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The mouse lymphoma L5178Y Tk +/− cell line is heterozygous for a codon 170 mutation in the p53 tumor suppressor gene

Mutation research, 1997-02, Vol.373 (2), p.157-165

1997

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Validation of a high-throughput in vitro alkaline elution/rat hepatocyte assay for DNA damage

Mutation research, 2007-04, Vol.629 (1), p.49-63

2007

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Evaluation of the Eμ-pim-1 Transgenic Mouse Model for Short-Term Carcinogenicity Testing

Toxicologic pathology, 1998-11, Vol.26 (6), p.750-756

1998

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Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds

Mutat. Res.-Genet. Toxicol, 1996-06, Vol.368 (2), p.59-101

1996

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Polymerase chain reaction/sequencing analysis of ras mutations in paraffin-embedded tissues as compared with 3T3 transfection and polymerase chain reaction/sequencing of frozen tumor deoxyribonucleic acids

Laboratory investigation, 1992-04, Vol.66 (4), p.504

1992

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An investigation of the role of microsomal oxidative metabolism in the in vivo genotoxicity of 1,2-dichloroethane

Toxicology and applied pharmacology, 1985, Vol.77 (1), p.36-46

1985

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DNA fingerprinting of 7,12-dimethylbenz[a]anthracene-induced and spontaneous CD-1 mouse liver tumors

Cancer research (Chicago, Ill.), 1990-09, Vol.50 (17), p.5245

1990

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Activation of the Ha-, Ki-, and N-ras genes in chemically induced liver tumors from CD-1 mice

Cancer research (Chicago, Ill.), 1992-06, Vol.52 (12), p.3347-3352

1992

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Comparative in vivo genotoxicity and acute hepatotoxicity of three 1,2-dihaloethanes

Carcinogenesis (New York), 1983-11, Vol.4 (11), p.1491-1494

1983

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Activation of the Ki-ras gene in spontaneous and chemically induced lung tumors in CD-1 mice

Molecular carcinogenesis, 1992, Vol.6 (1), p.68-75

1992

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p53 +/- Hemizygous Knockout Mouse: Overview of Available Data

The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens

Extent and Persistence of Streptozotocin-Induced DNA Damage and Cell Proliferation in Rat Kidney as Determined by in Vivo Alkaline Elution and BrdUrd Labeling Assays

Transgenic tumor models for carcinogen identification: the heterozygous Trp53-deficient and RasH2 mouse lines

Experimental Metastasis in Nude Mice of NIH 3T3 Cells Containing Various ras Genes

Short-term carcinogenesis bioassay of genotoxic procarcinogens in PIM® transgenic mice

Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors

Rapid induction of hyperplasia in vitro in rat bladder explants by elevated sodium ion concentrations and alkaline pH

Current status and use of short/medium term models for carcinogenicity testing of pharmaceuticals — scientific perspective

Rapid DNA degradation in primary rat hepatocytes treated with diverse cytotoxic chemicals: Analysis by pulsed field gel electrophoresis and implications for alkaline elution assays

Occupational Hazard Evaluation of P-Bromobenzyl Bromide from Tests for Genotoxicity

Genotoxicity of naturally occurring indole compounds: correlation between covalent DNA binding and other genotoxicity tests

Rapid induction of an experimental metastatic phenotype in first passage rat embryo cells by cotransfection of EJ c-Ha-ras and c-myc oncogenes

Murine p53 intron sequences 5-8 and their use in polymerase chain reaction/direct sequencing analysis of p53 mutations in CD-1 mouse liver and lung tumors

The effect of deuterium labeling on the genotoxicity of N-nitrosodimethylamine, epichlorohydrin and dimethyl sulfate

The mouse lymphoma L5178Y Tk +/− cell line is heterozygous for a codon 170 mutation in the p53 tumor suppressor gene

Validation of a high-throughput in vitro alkaline elution/rat hepatocyte assay for DNA damage

Evaluation of the Eμ-pim-1 Transgenic Mouse Model for Short-Term Carcinogenicity Testing

Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds

Polymerase chain reaction/sequencing analysis of ras mutations in paraffin-embedded tissues as compared with 3T3 transfection and polymerase chain reaction/sequencing of frozen tumor deoxyribonucleic acids

An investigation of the role of microsomal oxidative metabolism in the in vivo genotoxicity of 1,2-dichloroethane

DNA fingerprinting of 7,12-dimethylbenz[a]anthracene-induced and spontaneous CD-1 mouse liver tumors

Activation of the Ha-, Ki-, and N-ras genes in chemically induced liver tumors from CD-1 mice

Comparative in vivo genotoxicity and acute hepatotoxicity of three 1,2-dihaloethanes

Activation of the Ki-ras gene in spontaneous and chemically induced lung tumors in CD-1 mice

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