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A revised picture of the E2F transcriptional network and RB function

Current Opinion in Cell Biology, 2002-12, Vol.14 (6), p.684-691

2002

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The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer

Clinical cancer research, 2021-05, Vol.27 (10), p.2928-2937

2021

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GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

Genes & development, 2009-01, Vol.23 (1), p.24-36

2009

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Native E2F/RBF Complexes Contain Myb-Interacting Proteins and Repress Transcription of Developmentally Controlled E2F Target Genes

Cell, 2004-10, Vol.119 (2), p.181-193

2004

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Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies

PloS one, 2012-12, Vol.7 (12), p.e50920-e50920

2012

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Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway

Genes & development, 2003-09, Vol.17 (18), p.2308-2320

2003

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Abstract DDT02-03: AMG 509: A novel, humanized, half-Life extended, bispecific STEAP1 × CD3 T cell recruiting XmAb® 2+1 antibody

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.DDT02-03-DDT02-03

Nolan-Stevaux, Olivier

2020

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Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (49), p.E1275-E1284

2011

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Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway

Journal for immunotherapy of cancer, 2022-03, Vol.10 (3), p.e004348

2022

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Functional antagonism between E2F family members

Genes & development, 2001-08, Vol.15 (16), p.2146-2160

2001

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Measurement of Cancer Cell Growth Heterogeneity through Lentiviral Barcoding Identifies Clonal Dominance as a Characteristic of In Vivo Tumor Engraftment

PloS one, 2013-06, Vol.8 (6), p.e67316

2013

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718 AMG 509, a STEAP1 x CD3 bispecific XmAb® 2+1 immune therapy, exhibits avidity-driven binding and preferential killing of high STEAP1-expressing prostate and Ewing sarcoma cancer cells

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A760-A760

2020

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Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell–cold solid tumors

Science translational medicine, 2021-08, Vol.13 (608)

2021

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Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release

Clinical cancer research, 2019-07, Vol.25 (13), p.3921-3933

2019

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Abstract 6714: Genetic screens identify T cell co-stimulation as a key modifier of the redirected cytotoxicity of bispecific T cell engager (BiTE®) molecules

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.6714-6714

2020

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Retinoblastoma Family 2 is Required In Vivo for the Tissue-Specific Repression of dE2F2 target Genes

Cell cycle (Georgetown, Tex.), 2005-09, Vol.4 (9), p.1272-1280

2005

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Characterization of an Anti-CD70 Half-Life Extended Bispecific T-Cell Engager (HLE-BiTE) and Associated On-Target Toxicity in Cynomolgus Monkeys

Toxicological sciences, 2022-08, Vol.189 (1), p.32-50

2022

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The Ton System, an ABC Transporter, and a Universally Conserved GTPase Are Involved in Iron Utilization by Brucella melitensis 16M

Infection and Immunity, 2004-10, Vol.72 (10), p.5783-5790

2004

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AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer

Cancer discovery, 2024-01, Vol.14 (1), p.90-103

2024

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Abstract 585: Assessing ENPP3 as a renal cancer target for bispecific T-cell engager (BiTE) therapy

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.585-585

2016

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Preclinical Characterization of AMG 424, a Novel Humanized T Cell-Recruiting Bispecific Anti-CD3/CD38 Antibody

Blood, 2017-12, Vol.130, p.500-500

2017

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Abstract 4548: High throughput siRNA screens uncover a high rate of USP8 and ESCRT pathway dependency in squamous carcinoma cell lines

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4548-4548

2016

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Abstract 5079: Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-Endoglin antibodies

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.5079-5079

2013

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Abstract PR12: Assessing in vivo mechanisms regulating the therapeutic activity of bi-specific T-cell engager (BiTE®) molecules in immunocompetent mice expressing a chimeric human/mouse CD3ϵ receptor

Cancer immunology research, 2020-04, Vol.8 (4_Supplement), p.PR12-PR12

2020

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Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (49), p.19455-19456

2011

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A revised picture of the E2F transcriptional network and RB function

The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

Native E2F/RBF Complexes Contain Myb-Interacting Proteins and Repress Transcription of Developmentally Controlled E2F Target Genes

Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies

Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway

Abstract DDT02-03: AMG 509: A novel, humanized, half-Life extended, bispecific STEAP1 × CD3 T cell recruiting XmAb® 2+1 antibody

Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma

Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway

Functional antagonism between E2F family members

Measurement of Cancer Cell Growth Heterogeneity through Lentiviral Barcoding Identifies Clonal Dominance as a Characteristic of In Vivo Tumor Engraftment

718 AMG 509, a STEAP1 x CD3 bispecific XmAb® 2+1 immune therapy, exhibits avidity-driven binding and preferential killing of high STEAP1-expressing prostate and Ewing sarcoma cancer cells

Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell–cold solid tumors

Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release

Abstract 6714: Genetic screens identify T cell co-stimulation as a key modifier of the redirected cytotoxicity of bispecific T cell engager (BiTE®) molecules

Retinoblastoma Family 2 is Required In Vivo for the Tissue-Specific Repression of dE2F2 target Genes

Characterization of an Anti-CD70 Half-Life Extended Bispecific T-Cell Engager (HLE-BiTE) and Associated On-Target Toxicity in Cynomolgus Monkeys

The Ton System, an ABC Transporter, and a Universally Conserved GTPase Are Involved in Iron Utilization by Brucella melitensis 16M

AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer

Abstract 585: Assessing ENPP3 as a renal cancer target for bispecific T-cell engager (BiTE) therapy

Preclinical Characterization of AMG 424, a Novel Humanized T Cell-Recruiting Bispecific Anti-CD3/CD38 Antibody

Abstract 4548: High throughput siRNA screens uncover a high rate of USP8 and ESCRT pathway dependency in squamous carcinoma cell lines

Abstract 5079: Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-Endoglin antibodies

Abstract PR12: Assessing in vivo mechanisms regulating the therapeutic activity of bi-specific T-cell engager (BiTE®) molecules in immunocompetent mice expressing a chimeric human/mouse CD3ϵ receptor

Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma

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