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Identification of druggable cancer driver genes amplified across TCGA datasets

PloS one, 2014-05, Vol.9 (5), p.e98293

2014

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The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade

Cell reports (Cambridge), 2018-03, Vol.22 (11), p.2978-2994

2018

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Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response

Antioxidants & redox signaling, 2023-08, Vol.39 (4-6), p.351-373

2023

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Activation of Gcn2 by small molecules designed to be inhibitors

The Journal of biological chemistry, 2023-04, Vol.299 (4), p.104595-104595, Article 104595

2023

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PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma

PLoS genetics, 2016-12, Vol.12 (12), p.e1006518

2016

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Phosphorylation of eIF2 Directs ATF5 Translational Control in Response to Diverse Stress Conditions

The Journal of biological chemistry, 2008-03, Vol.283 (11), p.7064-7073

2008

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Adapting to cell stress from inside and out

Nature cell biology, 2019-07, Vol.21 (7), p.799-800

2019

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Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii

Antimicrobial agents and chemotherapy, 2018-11, Vol.62 (11)

2018

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PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors

Clinical cancer research, 2023-12, Vol.29 (23), p.4870-4882

2023

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A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells

Clinical cancer research, 2023-12, Vol.29 (24), p.5155-5172

2023

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GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

eLife, 2022-09, Vol.11

2022

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TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma

Cancer research (Chicago, Ill.), 2024-04, Vol.84 (8), p.1286-1302

2024

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GCN2 is required to maintain core body temperature in mice during acute cold

American journal of physiology: endocrinology and metabolism, 2023-11, Vol.325 (5), p.E624-E637

2023

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Asparagine bioavailability regulates the translation of MYC oncogene

Oncogene, 2022-10, Vol.41 (44), p.4855-4865

2022

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Obtaining Functional Proteomics Insights From Thermal Proteome Profiling Through Optimized Melt Shift Calculation and Statistical Analysis With InflectSSP

Molecular & cellular proteomics, 2023-09, Vol.22 (9), p.100630, Article 100630

2023

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Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice

The Journal of clinical investigation, 2024-06, Vol.134 (16), p.1-15

2024

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Targeting GCN2 Regulation of Amino Acid Homeostasis in Prostate Cancer

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Integration of General Amino Acid Control and Target of Rapamycin (TOR) Regulatory Pathways in Nitrogen Assimilation in Yeast

The Journal of biological chemistry, 2010-05, Vol.285 (22), p.16893-16911

2010

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Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication?

Virology (New York, N.Y.), 2007-07, Vol.364 (1), p.1-9

2007

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mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress

Molecular cancer research, 2015-10, Vol.13 (10), p.1377-1388

2015

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A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity

The Journal of experimental medicine, 2007-05, Vol.204 (5), p.1025-1036

2007

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How do tumours adapt to nutrient stress?

The EMBO journal, 2010-06, Vol.29 (12), p.1946-1947

2010

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Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment

Frontiers in medicine, 2023-04, Vol.10, p.1146115

2023

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Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells

Cell death & disease, 2018-02, Vol.9 (3), p.254-12, Article 254

2018

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IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease

The Journal of immunology (1950), 2009-07, Vol.183 (1), p.568-577

2009

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Identification of druggable cancer driver genes amplified across TCGA datasets

The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade

Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response

Activation of Gcn2 by small molecules designed to be inhibitors

PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma

Phosphorylation of eIF2 Directs ATF5 Translational Control in Response to Diverse Stress Conditions

Adapting to cell stress from inside and out

Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii

PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors

A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma

GCN2 is required to maintain core body temperature in mice during acute cold

Asparagine bioavailability regulates the translation of MYC oncogene

Obtaining Functional Proteomics Insights From Thermal Proteome Profiling Through Optimized Melt Shift Calculation and Statistical Analysis With InflectSSP

Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice

Targeting GCN2 Regulation of Amino Acid Homeostasis in Prostate Cancer

Integration of General Amino Acid Control and Target of Rapamycin (TOR) Regulatory Pathways in Nitrogen Assimilation in Yeast

Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication?

mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress

A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity

How do tumours adapt to nutrient stress?

Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment

Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells

IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease

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