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Preservation of in vitro function of platelets stored in the presence of a synthetic dual inhibitor of factor Xa and thrombin

Journal of thrombosis and haemostasis, 2007-10, Vol.5 (10), p.2119-2126

2007

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Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition

Journal of molecular biology, 2001-10, Vol.313 (3), p.593-614

2001

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Three-Dimensional Quantitative Structure−Activity Relationship Analyses Using Comparative Molecular Field Analysis and Comparative Molecular Similarity Indices Analysis To Elucidate Selectivity Differences of Inhibitors Binding to Trypsin, Thrombin, and Factor Xa

Journal of medicinal chemistry, 1999-02, Vol.42 (3), p.458-477

1999

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Advances in the development of thrombin inhibitors

Expert opinion on investigational drugs, 2001-05, Vol.10 (5), p.845-864

2001

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Blood coagulation and fibrinolysis after extreme short-term exercise

Thrombosis research, 2003-03, Vol.109 (5), p.271-277

2003

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Expression and Proteolysis of Vascular Endothelial Growth Factor is Increased in Chronic Wounds

Journal of investigative dermatology, 2000-07, Vol.115 (1), p.12-18

2000

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Structural and Functional Analyses of Benzamidine-Based Inhibitors in Complex with Trypsin: Implications for the Inhibition of Factor Xa, tPA, and Urokinase

Journal of medicinal chemistry, 1998-12, Vol.41 (27), p.5445-5456

1998

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(4-Aminomethyl)Phenylguanidine Derivatives as Nonpeptidic Highly Selective Inhibitors of Human Urokinase

Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (10), p.5113-5118

2000

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Synthetic Inhibitors of Thrombin and Factor Xa: From Bench to Bedside

Thrombosis research, 1999-03, Vol.93 (5), p.203-241

1999

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Thrombin Potential and Thrombin Generation After Exhaustive Exercise

International journal of sports medicine, 2002-10, Vol.23 (7), p.500-504

2002

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Cyanopeptide analogues: new lead structures for the design and synthesis of new thrombin inhibitors

Pharmazie, 2002-11, Vol.57 (11), p.729-732

2002

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The ability of thrombin inhibitors to reduce the thrombin activity generated in plasma on extrinsic and intrinsic activation

Thrombosis and haemostasis, 1997-03, Vol.77 (3), p.498

1997

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Inhibition of thrombin generation in plasma by inhibitors of factor Xa

Thrombosis and haemostasis, 1997-10, Vol.78 (4), p.1215

1997

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3-Amidinophenylalanine-based inhibitors of urokinase

Bioorganic & medicinal chemistry letters, 1999-11, Vol.9 (21), p.3147-3152

1999

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Transport of peptidomimetic thrombin inhibitors with a 3-amidino-phenylalanine structure : Permeability and efflux mechanism in monolayers of a human intestinal cell line (Caco-2)

Pharmaceutical research, 2001-08, Vol.18 (8), p.1110-1118

2001

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Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors

The Journal of biological chemistry, 1997-08, Vol.272 (35), p.21713-21719

1997

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The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition

The Journal of biological chemistry, 1997-08, Vol.272 (32), p.19931-19937

1997

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Influence of structural variations in peptidomimetic 4-amidinophenylalanine-derived thrombin inhibitors on plasma clearance and biliary excretion in rats

Pharmaceutical research, 2002-07, Vol.19 (7), p.1027-1033

2002

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(R)-3-Amidinophenylalanine-Derived Inhibitors of Factor Xa with a Novel Active-Site Binding Mode

Biological chemistry, 2002-07, Vol.383 (7-8), p.1185-1191

2002

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Synthesis and Structure−Activity Relationships of Potent Thrombin Inhibitors: Piperazides of 3-Amidinophenylalanine

Journal of medicinal chemistry, 1997-09, Vol.40 (19), p.3091-3099

1997

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Determination of Activated Factor IX in Factor IX Concentrates with a Chromogenic Substrate

Thrombosis research, 1998-10, Vol.92 (2), p.99-102

1998

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Structure-Activity Relationships of New NAPAP-Analogs

Journal of enzyme inhibition, 2001, Vol.16 (3), p.241-249

2001

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Trypsin- and SLIGRL-induced vascular relaxation and the inhibition by benzamidine derivatives

Thrombosis and haemostasis, 1997, Vol.78 (5), p.1399

1997

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Urethanyl-3-Amidinophenylalanine Derivatives as Inhibitors of Factor Xa. X-Ray Crystal Structure of a Trypsin/Inhibitor Complex and Modeling Studies

Biological chemistry, 2000-04, Vol.381 (4), p.321-329

2000

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Factor-XIII-research: Pioneer achievement and progress

Hämostaseologie, 2002-02, Vol.22 (1), p.3

2002

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Preservation of in vitro function of platelets stored in the presence of a synthetic dual inhibitor of factor Xa and thrombin

Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition

Three-Dimensional Quantitative Structure−Activity Relationship Analyses Using Comparative Molecular Field Analysis and Comparative Molecular Similarity Indices Analysis To Elucidate Selectivity Differences of Inhibitors Binding to Trypsin, Thrombin, and Factor Xa

Advances in the development of thrombin inhibitors

Blood coagulation and fibrinolysis after extreme short-term exercise

Expression and Proteolysis of Vascular Endothelial Growth Factor is Increased in Chronic Wounds

Structural and Functional Analyses of Benzamidine-Based Inhibitors in Complex with Trypsin: Implications for the Inhibition of Factor Xa, tPA, and Urokinase

(4-Aminomethyl)Phenylguanidine Derivatives as Nonpeptidic Highly Selective Inhibitors of Human Urokinase

Synthetic Inhibitors of Thrombin and Factor Xa: From Bench to Bedside

Thrombin Potential and Thrombin Generation After Exhaustive Exercise

Cyanopeptide analogues: new lead structures for the design and synthesis of new thrombin inhibitors

The ability of thrombin inhibitors to reduce the thrombin activity generated in plasma on extrinsic and intrinsic activation

Inhibition of thrombin generation in plasma by inhibitors of factor Xa

3-Amidinophenylalanine-based inhibitors of urokinase

Transport of peptidomimetic thrombin inhibitors with a 3-amidino-phenylalanine structure : Permeability and efflux mechanism in monolayers of a human intestinal cell line (Caco-2)

Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors

The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition

Influence of structural variations in peptidomimetic 4-amidinophenylalanine-derived thrombin inhibitors on plasma clearance and biliary excretion in rats

(R)-3-Amidinophenylalanine-Derived Inhibitors of Factor Xa with a Novel Active-Site Binding Mode

Synthesis and Structure−Activity Relationships of Potent Thrombin Inhibitors: Piperazides of 3-Amidinophenylalanine

Determination of Activated Factor IX in Factor IX Concentrates with a Chromogenic Substrate

Structure-Activity Relationships of New NAPAP-Analogs

Trypsin- and SLIGRL-induced vascular relaxation and the inhibition by benzamidine derivatives

Urethanyl-3-Amidinophenylalanine Derivatives as Inhibitors of Factor Xa. X-Ray Crystal Structure of a Trypsin/Inhibitor Complex and Modeling Studies

Factor-XIII-research: Pioneer achievement and progress

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