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Structure and function of the human calcium‐sensing receptor: insights from natural and engineered mutations and allosteric modulators

Journal of cellular and molecular medicine, 2007-09, Vol.11 (5), p.908-922

2007

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Inherited diseases involving g proteins and g protein-coupled receptors

Annual review of medicine, 2004-01, Vol.55 (1), p.27-39

2004

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A double negative: inhibition of hepatic Gi signaling improves glucose homeostasis

The Journal of clinical investigation, 2018-02, Vol.128 (2), p.567-569

Spiegel, Allen M

2018

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Recapitulation of Pancreatic Neuroendocrine Tumors in Human Multiple Endocrine Neoplasia Type I Syndrome via Pdx1-Directed Inactivation of Men1

Cancer research (Chicago, Ill.), 2009-03, Vol.69 (5), p.1858-1866

2009

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Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout

Molecular and Cellular Biology, 2003-09, Vol.23 (17), p.6075-6085

2003

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Molecular Pathology of the MEN1 Gene

Annals of the New York Academy of Sciences, 2004-04, Vol.1014 (1), p.189-198

2004

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A Region in the Seven-transmembrane Domain of the Human Ca2+ Receptor Critical for Response to Ca2

The Journal of biological chemistry, 2005-02, Vol.280 (6), p.5113-5120

2005

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Transcription Factor JunD, Deprived of Menin, Switches from Growth Suppressor to Growth Promoter

Proceedings of the National Academy of Sciences - PNAS, 2003-09, Vol.100 (19), p.10770-10775

2003

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THE JEREMIAH METZGER LECTURE: A BRIEF HISTORY OF EUGENICS IN AMERICA: IMPLICATIONS FOR MEDICINE IN THE 21ST CENTURY

Transactions of the American Clinical and Climatological Association, 2019-01, Vol.130, p.216-234

Spiegel, Allen M

2019

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The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1)

Endocrinology (Philadelphia), 2015-09, Vol.156 (9), p.3114-3121

2015

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G Proteins — The Disease Spectrum Expands

The New England journal of medicine, 2013-06, Vol.368 (26), p.2515-2516

Spiegel, Allen M

2013

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The 32-Kilodalton Subunit of Replication Protein A Interacts with Menin, the Product of the MEN1 Tumor Suppressor Gene

Molecular and Cellular Biology, 2003-01, Vol.23 (2), p.493-509

2003

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A Missense Mutation in the Seven-transmembrane Domain of the Human Ca2+ Receptor Converts a Negative Allosteric Modulator into a Positive Allosteric Modulator

The Journal of biological chemistry, 2006-07, Vol.281 (30), p.21558-21565

2006

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Distribution of Menin-Occupied Regions in Chromatin Specifies a Broad Role of Menin in Transcriptional Regulation

Neoplasia (New York, N.Y.), 2007-02, Vol.9 (2), p.101-107

2007

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Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders

The Journal of biological chemistry, 2016-05, Vol.291 (20), p.10876-10885

2016

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Activating Mutations of the Stimulatory G Protein in the McCune–Albright Syndrome

The New England journal of medicine, 1991-12, Vol.325 (24), p.1688-1695

1991

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Identification of Acidic Residues in the Extracellular Loops of the Seven-transmembrane Domain of the Human Ca2+ Receptor Critical for Response to Ca2+ and a Positive Allosteric Modulator

The Journal of biological chemistry, 2002-11, Vol.277 (48), p.46622-46631

2002

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Parathyroid tumor development involves deregulation of homeobox genes

Endocrine-related cancer, 2008-03, Vol.15 (1), p.267-275

2008

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'Personalized medicine' to identify genetic risks for type 2 diabetes and focus prevention: can it fulfill its promise?

Health Affairs, 2012-01, Vol.31 (1), p.43-49

2012

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Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis

PLoS genetics, 2006-04, Vol.2 (4), p.e51-e51

2006

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Commentary: new guidelines for NIH peer review: improving the system or undermining it?

Academic medicine, 2010-05, Vol.85 (5), p.746-748

Spiegel, Allen M

2010

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A Mouse Model of Multiple Endocrine Neoplasia, Type 1, Develops Multiple Endocrine Tumors

Proceedings of the National Academy of Sciences - PNAS, 2001-01, Vol.98 (3), p.1118-1123

2001

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The stem cell wars: a dispatch from the front

Transactions of the American Clinical and Climatological Association, 2013, Vol.124, p.94-110

Spiegel, Allen M

2013

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Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function

Trends in endocrinology and metabolism, 2003-08, Vol.14 (6), p.282-288

2003

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Research in academic medical centers: two threats to sustainable support

Science translational medicine, 2015-05, Vol.7 (289), p.289fs22

2015

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Structure and function of the human calcium‐sensing receptor: insights from natural and engineered mutations and allosteric modulators

Inherited diseases involving g proteins and g protein-coupled receptors

A double negative: inhibition of hepatic Gi signaling improves glucose homeostasis

Recapitulation of Pancreatic Neuroendocrine Tumors in Human Multiple Endocrine Neoplasia Type I Syndrome via Pdx1-Directed Inactivation of Men1

Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout

Molecular Pathology of the MEN1 Gene

A Region in the Seven-transmembrane Domain of the Human Ca2+ Receptor Critical for Response to Ca2

Transcription Factor JunD, Deprived of Menin, Switches from Growth Suppressor to Growth Promoter

THE JEREMIAH METZGER LECTURE: A BRIEF HISTORY OF EUGENICS IN AMERICA: IMPLICATIONS FOR MEDICINE IN THE 21ST CENTURY

The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1)

G Proteins — The Disease Spectrum Expands

The 32-Kilodalton Subunit of Replication Protein A Interacts with Menin, the Product of the MEN1 Tumor Suppressor Gene

A Missense Mutation in the Seven-transmembrane Domain of the Human Ca2+ Receptor Converts a Negative Allosteric Modulator into a Positive Allosteric Modulator

Distribution of Menin-Occupied Regions in Chromatin Specifies a Broad Role of Menin in Transcriptional Regulation

Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders

Activating Mutations of the Stimulatory G Protein in the McCune–Albright Syndrome

Identification of Acidic Residues in the Extracellular Loops of the Seven-transmembrane Domain of the Human Ca2+ Receptor Critical for Response to Ca2+ and a Positive Allosteric Modulator

Parathyroid tumor development involves deregulation of homeobox genes

'Personalized medicine' to identify genetic risks for type 2 diabetes and focus prevention: can it fulfill its promise?

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis

Commentary: new guidelines for NIH peer review: improving the system or undermining it?

A Mouse Model of Multiple Endocrine Neoplasia, Type 1, Develops Multiple Endocrine Tumors

The stem cell wars: a dispatch from the front

Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function

Research in academic medical centers: two threats to sustainable support

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