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Understanding the Mechanisms Behind Trastuzumab Therapy for Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

Journal of clinical oncology, 2009-12, Vol.27 (34), p.5838-5847

2009

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Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer

Breast cancer research : BCR, 2012-04, Vol.14 (2), p.R62-R62, Article R62

2012

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Medical oncologists' perspectives of the Veterans Affairs National Precision Oncology Program

PloS one, 2020-07, Vol.15 (7), p.e0235861-e0235861

2020

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Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis

PloS one, 2014-02, Vol.9 (2), p.e88983-e88983

2014

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An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models

Breast cancer research : BCR, 2013-09, Vol.15 (5), p.R85-R85, Article R85

2013

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A Model of Acquired Autoresistance to a Potent ErbB2 Tyrosine Kinase Inhibitor and a Therapeutic Strategy to Prevent Its Onset in Breast Cancer

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (20), p.7795-7800

2006

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X-Ray Psoralen Activated Cancer Therapy (X-PACT)

PloS one, 2016-09, Vol.11 (9), p.e0162078-e0162078

2016

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Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor

PloS one, 2015-11, Vol.10 (11), p.e0142845-e0142845

2015

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Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors

Clinical cancer research, 2008-11, Vol.14 (21), p.6730-6734

2008

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Phase I Safety, Pharmacokinetics, and Clinical Activity Study of Lapatinib (GW572016), a Reversible Dual Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinases, in Heavily Pretreated Patients With Metastatic Carcinomas

Journal of clinical oncology, 2005-08, Vol.23 (23), p.5305-5313

2005

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Phase II Study of Predictive Biomarker Profiles for Response Targeting Human Epidermal Growth Factor Receptor 2 (HER-2) in Advanced Inflammatory Breast Cancer With Lapatinib Monotherapy

Journal of clinical oncology, 2008-03, Vol.26 (7), p.1066-1072

2008

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Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

Oncogene, 2002-09, Vol.21 (41), p.6255-6263

2002

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Visualizing Borrelia burgdorferi Infection Using a Small-Molecule Imaging Probe

Journal of clinical microbiology, 2021-06, Vol.59 (7), p.e0231320-e0231320

2021

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Comparison of Annotation Services for Next-Generation Sequencing in a Large-Scale Precision Oncology Program

JCO precision oncology, 2020-11 (4), p.212-221

2020

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Study of the Biologic Effects of Lapatinib, a Reversible Inhibitor of ErbB1 and ErbB2 Tyrosine Kinases, on Tumor Growth and Survival Pathways in Patients With Advanced Malignancies

Journal of clinical oncology, 2005-04, Vol.23 (11), p.2502-2512

2005

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Phase II Study to Evaluate the Efficacy and Safety of Neoadjuvant Lapatinib Plus Paclitaxel in Patients With Inflammatory Breast Cancer

Journal of clinical oncology, 2010-07, Vol.28 (20), p.3248-3255

2010

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The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients

Cancer Immunology, Immunotherapy, 2008-08, Vol.57 (8), p.1115-1124

2008

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A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53

Science signaling, 2013-05, Vol.6 (274), p.ra32

2013

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Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells

Oncogene, 2005-09, Vol.24 (41), p.6213-6221

2005

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Pertuzumab protects the achilles' heel of trastuzumab--emtansine

Clinical cancer research, 2014-01, Vol.20 (2), p.278-280

2014

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Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells

Molecular cancer research, 2021-05, Vol.19 (5), p.886-899

2021

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Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells

Proceedings of the National Academy of Sciences - PNAS, 2007-06, Vol.104 (25), p.10607-10612

2007

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A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo

ACS chemical biology, 2017-04, Vol.12 (4), p.1047-1055

2017

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Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine

PLoS medicine, 2016-12, Vol.13 (12), p.e1002136

2016

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Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration

Stem cells (Dayton, Ohio), 2018-02, Vol.36 (2), p.252-264

2018

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Understanding the Mechanisms Behind Trastuzumab Therapy for Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer

Medical oncologists' perspectives of the Veterans Affairs National Precision Oncology Program

Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis

An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models

A Model of Acquired Autoresistance to a Potent ErbB2 Tyrosine Kinase Inhibitor and a Therapeutic Strategy to Prevent Its Onset in Breast Cancer

X-Ray Psoralen Activated Cancer Therapy (X-PACT)

Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor

Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors

Phase I Safety, Pharmacokinetics, and Clinical Activity Study of Lapatinib (GW572016), a Reversible Dual Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinases, in Heavily Pretreated Patients With Metastatic Carcinomas

Phase II Study of Predictive Biomarker Profiles for Response Targeting Human Epidermal Growth Factor Receptor 2 (HER-2) in Advanced Inflammatory Breast Cancer With Lapatinib Monotherapy

Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

Visualizing Borrelia burgdorferi Infection Using a Small-Molecule Imaging Probe

Comparison of Annotation Services for Next-Generation Sequencing in a Large-Scale Precision Oncology Program

Study of the Biologic Effects of Lapatinib, a Reversible Inhibitor of ErbB1 and ErbB2 Tyrosine Kinases, on Tumor Growth and Survival Pathways in Patients With Advanced Malignancies

Phase II Study to Evaluate the Efficacy and Safety of Neoadjuvant Lapatinib Plus Paclitaxel in Patients With Inflammatory Breast Cancer

The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients

A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53

Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells

Pertuzumab protects the achilles' heel of trastuzumab--emtansine

Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells

Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells

A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo

Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine

Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration

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