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Discovery of Novel 7‑Aryl 7‑Deazapurine 3′-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi

Journal of medicinal chemistry, 2018-10, Vol.61 (20), p.9287-9300

2018

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Ciprofloxacin Derivatives Affect Parasite Cell Division and Increase the Survival of Mice Infected with Toxoplasma gondii

PloS one, 2015-05, Vol.10 (5), p.e0125705-e0125705

2015

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6‐Methyl‐7‐Aryl‐7‐Deazapurine Nucleosides as Anti‐Trypanosoma cruzi Agents: Structure‐Activity Relationship and in vivo Efficacy

ChemMedChem, 2021-07, Vol.16 (14), p.2231-2253

2021

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Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches

Molecules (Basel, Switzerland), 2022-11, Vol.27 (22), p.8087

2022

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Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae

Journal of medicinal chemistry, 2018-12, Vol.61 (23), p.10910-10921

2018

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In Vitro Phenotypic Activity and In Silico Analysis of Natural Products from Brazilian Biodiversity on Trypanosoma cruzi

Molecules (Basel, Switzerland), 2021-09, Vol.26 (18), p.5676

2021

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Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruzi Activity

Bioinorganic Chemistry and Applications, 2016-01, Vol.2016, p.5027404-11

2016

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Trypanosoma cruzi targets for new chemotherapeutic approaches

Expert opinion on therapeutic targets, 2009-01, Vol.13 (1), p.105-121

2009

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Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi

Antimicrobial agents and chemotherapy, 2016-02, Vol.60 (2), p.1058-1066

2016

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In Vitro and In Vivo Studies of the Trypanocidal Activity of a Diarylthiophene Diamidine against Trypanosoma cruzi

Antimicrobial Agents and Chemotherapy, 2008-09, Vol.52 (9), p.3307-3314

2008

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Synthesis, in vitro Toxicity, and Antitrypanosomal Activity of Arylated and Diarylated Thiazoles

Journal of the Brazilian Chemical Society, 2024, Vol.35 (1)

2024

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Discovery of Pyrrolo[2,3‑b]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-Trypanosoma cruzi Agents

Journal of medicinal chemistry, 2019-10, Vol.62 (19), p.8847-8865

2019

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Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

International journal of molecular sciences, 2016-08, Vol.17 (8), p.1340-1340

2016

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Norfloxacin Zn(II)-based complexes: acid base ionization constant determination, DNA and albumin binding properties and the biological effect against Trypanosoma cruzi

Biometals, 2013-10, Vol.26 (5), p.813-825

2013

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SB-431542, a Transforming Growth Factor β Inhibitor, Impairs Trypanosoma cruzi Infection in Cardiomyocytes and Parasite Cycle Completion

Antimicrobial Agents and Chemotherapy, 2007-08, Vol.51 (8), p.2905-2910

2007

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The association of myocardial strain with cardiac magnetic resonance and clinical outcomes in patients with acute myocarditis

Frontiers in cardiovascular medicine, 2023-07, Vol.10, p.1121083-1121083

2023

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Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2‐Benzyl‐5‐nitroindazole‐Derived Amines

ChemMedChem, 2018-06, Vol.13 (12), p.1246-1259

2018

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Atorvastatin Downregulates In Vitro Methyl Methanesulfonate and Cyclophosphamide Alkylation-Mediated Cellular and DNA Injuries

Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (1), p.7820890-7820890

2018

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Repurposing Strategy of Atorvastatin against Trypanosoma cruzi: In Vitro Monotherapy and Combined Therapy with Benznidazole Exhibit Synergistic Trypanocidal Activity

Antimicrobial agents and chemotherapy, 2018-09, Vol.62 (9)

2018

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In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi

Journal of antimicrobial chemotherapy, 2009-10, Vol.64 (4), p.747-750

2009

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Copper(II)–fluoroquinolone complexes with anti-Trypanosoma cruzi activity and DNA binding ability

Biometals, 2012-10, Vol.25 (5), p.951-960

2012

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Cellular Effects of Reversed Amidines on Trypanosoma cruzi

Antimicrobial Agents and Chemotherapy, 2007-11, Vol.51 (11), p.3803-3809

2007

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Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain

Antimicrobial agents and chemotherapy, 2017-04, Vol.61 (4)

2017

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The Trypanocidal Activity of Amidine Compounds Does Not Correlate with Their Binding Affinity to Trypanosoma cruzi Kinetoplast DNA

Antimicrobial Agents and Chemotherapy, 2011-10, Vol.55 (10), p.4765-4773

2011

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In Vitro and In Vivo Studies of the Trypanocidal Effect of Novel Quinolines

Antimicrobial agents and chemotherapy, 2018-02, Vol.62 (2)

2018

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Discovery of Novel 7‑Aryl 7‑Deazapurine 3′-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi

Ciprofloxacin Derivatives Affect Parasite Cell Division and Increase the Survival of Mice Infected with Toxoplasma gondii

6‐Methyl‐7‐Aryl‐7‐Deazapurine Nucleosides as Anti‐Trypanosoma cruzi Agents: Structure‐Activity Relationship and in vivo Efficacy

Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches

Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae

In Vitro Phenotypic Activity and In Silico Analysis of Natural Products from Brazilian Biodiversity on Trypanosoma cruzi

Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruzi Activity

Trypanosoma cruzi targets for new chemotherapeutic approaches

Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi

In Vitro and In Vivo Studies of the Trypanocidal Activity of a Diarylthiophene Diamidine against Trypanosoma cruzi

Synthesis, in vitro Toxicity, and Antitrypanosomal Activity of Arylated and Diarylated Thiazoles

Discovery of Pyrrolo[2,3‑b]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-Trypanosoma cruzi Agents

Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

Norfloxacin Zn(II)-based complexes: acid base ionization constant determination, DNA and albumin binding properties and the biological effect against Trypanosoma cruzi

SB-431542, a Transforming Growth Factor β Inhibitor, Impairs Trypanosoma cruzi Infection in Cardiomyocytes and Parasite Cycle Completion

The association of myocardial strain with cardiac magnetic resonance and clinical outcomes in patients with acute myocarditis

Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2‐Benzyl‐5‐nitroindazole‐Derived Amines

Atorvastatin Downregulates In Vitro Methyl Methanesulfonate and Cyclophosphamide Alkylation-Mediated Cellular and DNA Injuries

Repurposing Strategy of Atorvastatin against Trypanosoma cruzi: In Vitro Monotherapy and Combined Therapy with Benznidazole Exhibit Synergistic Trypanocidal Activity

In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi

Copper(II)–fluoroquinolone complexes with anti-Trypanosoma cruzi activity and DNA binding ability

Cellular Effects of Reversed Amidines on Trypanosoma cruzi

Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain

The Trypanocidal Activity of Amidine Compounds Does Not Correlate with Their Binding Affinity to Trypanosoma cruzi Kinetoplast DNA

In Vitro and In Vivo Studies of the Trypanocidal Effect of Novel Quinolines

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