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Targeting antioxidants to mitochondria by conjugation to lipophilic cations

Annual review of pharmacology and toxicology, 2007-01, Vol.47 (1), p.629-656

2007

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Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

Nature medicine, 2013-06, Vol.19 (6), p.753-759

2013

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NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

Neuropsychopharmacology (New York, N.Y.), 2013-08, Vol.38 (9), p.1609-1616

2013

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Animal and human studies with the mitochondria-targeted antioxidant MitoQ

Annals of the New York Academy of Sciences, 2010-07, Vol.1201 (1), p.96-103

2010

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A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

Movement disorders, 2010-08, Vol.25 (11), p.1670-1674

2010

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The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

Liver international, 2010-08, Vol.30 (7), p.1019-1026

2010

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Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

The FASEB journal, 2005-07, Vol.19 (9), p.1088-1095

2005

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Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

Biochemical journal, 2008-05, Vol.411 (3), p.633-645

2008

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Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis

Free radical biology & medicine, 2014-05, Vol.70, p.204-213

2014

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Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation

Biochemical journal, 2010-08, Vol.430 (1), p.49-59

2010

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Characteristics of memory B cells elicited by a highly efficacious HPV vaccine in subjects with no pre-existing immunity

PLoS pathogens, 2014-10, Vol.10 (10), p.e1004461-e1004461

2014

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Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism

PloS one, 2013-04, Vol.8 (4), p.e60253

2013

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mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

Proceedings of the National Academy of Sciences - PNAS, 2009-06, Vol.106 (26), p.10764-10769

2009

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Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats

Arteriosclerosis, thrombosis, and vascular biology, 2012-02, Vol.32 (2), p.325-334

2012

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Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus

Journal of neuroinflammation, 2016-05, Vol.13 (1), p.98-98, Article 98

2016

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Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G

Basic research in cardiology, 2013-03, Vol.108 (2), p.337-337, Article 337

2013

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Assessing the Delivery of Molecules to the Mitochondrial Matrix Using Click Chemistry

Chembiochem : a European journal of chemical biology, 2016-07, Vol.17 (14), p.1312-1316

2016

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Direct Modification of the Proinflammatory Cytokine Macrophage Migration Inhibitory Factor by Dietary Isothiocyanates

The Journal of biological chemistry, 2009-11, Vol.284 (47), p.32425-32433

2009

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A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms

PloS one, 2015-03, Vol.10 (3), p.e0120460

2015

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Interaction of the Mitochondria-targeted Antioxidant MitoQ with Phospholipid Bilayers and Ubiquinone Oxidoreductases

The Journal of biological chemistry, 2007-05, Vol.282 (20), p.14708-14718

2007

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Delivery of Bioactive Molecules to Mitochondria in vivo

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (9), p.5407-5412

2003

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Mitochondrial pharmacology

Trends in pharmacological sciences (Regular ed.), 2012-06, Vol.33 (6), p.341-352

2012

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Accumulation of lipophilic dications by mitochondria and cells

Biochemical journal, 2006-11, Vol.400 (1), p.199-208

2006

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The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys

The Journal of pharmacology and experimental therapeutics, 2011-03, Vol.336 (3), p.682-692

2011

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Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

Nature medicine, 2001-10, Vol.7 (10), p.1111-1117

2001

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Targeting antioxidants to mitochondria by conjugation to lipophilic cations

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

Animal and human studies with the mitochondria-targeted antioxidant MitoQ

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis

Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation

Characteristics of memory B cells elicited by a highly efficacious HPV vaccine in subjects with no pre-existing immunity

Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism

mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats

Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus

Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G

Assessing the Delivery of Molecules to the Mitochondrial Matrix Using Click Chemistry

Direct Modification of the Proinflammatory Cytokine Macrophage Migration Inhibitory Factor by Dietary Isothiocyanates

A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms

Interaction of the Mitochondria-targeted Antioxidant MitoQ with Phospholipid Bilayers and Ubiquinone Oxidoreductases

Delivery of Bioactive Molecules to Mitochondria in vivo

Mitochondrial pharmacology

Accumulation of lipophilic dications by mitochondria and cells

The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys

Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

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