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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

Nature (London), 2011-06, Vol.474 (7353), p.658-661

2011

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Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A

Nature communications, 2021-11, Vol.12 (1), p.6864-6864, Article 6864

2021

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Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

The Journal of biological chemistry, 2013-04, Vol.288 (15), p.10406-10417

2013

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Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1

PLoS pathogens, 2013-07, Vol.9 (7), p.e1003496-e1003496

2013

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Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle

Proceedings of the National Academy of Sciences - PNAS, 2007-07, Vol.104 (28), p.11778-11783

2007

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Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection

PLoS pathogens, 2008-05, Vol.4 (5), p.e1000059

2008

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Specific Recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 Guanine Nucleotide Exchange Factors

The Journal of biological chemistry, 2008-02, Vol.283 (6), p.3088-3096

2008

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SIV vpx is essential for macrophage infection but not for development of AIDS

PloS one, 2014-01, Vol.9 (1), p.e84463

2014

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HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis

PLoS biology, 2004-01, Vol.2 (1), p.E6-E6

2004

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Nef Proteins from Diverse Groups of Primate Lentiviruses Downmodulate CXCR4 To Inhibit Migration to the Chemokine Stromal Derived Factor 1

Journal of Virology, 2005-08, Vol.79 (16), p.10650-10659

2005

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Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency Virus

Journal of Virology, 2004-12, Vol.78 (23), p.13335-13344

2004

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Modulation of Different Human Immunodeficiency Virus Type 1 Nef Functions during Progression to AIDS

Journal of Virology, 2001-04, Vol.75 (8), p.3657-3665

2001

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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

Nature (London), 2011-06, Vol.474 (7353), p.658-661

2011

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HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1

The Journal of biological chemistry, 2012-04, Vol.287 (15), p.12550-12558

2012

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Cooperative Interactions of Simian Immunodeficiency Virus Nef, AP-2, and CD3-ζ Mediate the Selective Induction of T-Cell Receptor-CD3 Endocytosis

Journal of Virology, 2003-07, Vol.77 (14), p.8116-8126

2003

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Human N-Myristoyltransferases Form Stable Complexes with Lentiviral Nef and Other Viral and Cellular Substrate Proteins

Journal of Virology, 2005-01, Vol.79 (2), p.1133-1141

2005

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HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection

mBio, 2018-10, Vol.9 (5)

2018

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HIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells

Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (19), p.9568-9577

2019

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CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain

The Journal of biological chemistry, 2015-05, Vol.290 (21), p.13279-13292

2015

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Simian and Human Immunodeficiency Virus Nef Proteins Use Different Surfaces To Downregulate Class I Major Histocompatibility Complex Antigen Expression

Journal of Virology, 2000-06, Vol.74 (12), p.5691-5701

2000

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HIV-1 Vpr protein directly loads helicase-like transcription factor (HLTF) onto the CRL4-DCAF1 E3 ubiquitin ligase

The Journal of biological chemistry, 2017-12, Vol.292 (51), p.21117-21127

2017

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HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins

Proceedings of the National Academy of Sciences - PNAS, 2016-07, Vol.113 (27), p.E3921-E3930

2016

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Mechanism of allosteric activation of SAMHD1 by dGTP

Nature structural & molecular biology, 2013-11, Vol.20 (11), p.1304-1309

2013

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Comprehensive Analysis of Nef Functions Selected in Simian Immunodeficiency Virus-Infected Macaques

Journal of Virology, 2004-10, Vol.78 (19), p.10588-10597

2004

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Disrupting Surfaces of Nef Required for Downregulation of CD4 and for Enhancement of Virion Infectivity Attenuates Simian Immunodeficiency Virus Replication In Vivo

Journal of Virology, 2000-11, Vol.74 (21), p.9836-9844

2000

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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1

Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle

Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection

Specific Recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 Guanine Nucleotide Exchange Factors

SIV vpx is essential for macrophage infection but not for development of AIDS

HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis

Nef Proteins from Diverse Groups of Primate Lentiviruses Downmodulate CXCR4 To Inhibit Migration to the Chemokine Stromal Derived Factor 1

Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency Virus

Modulation of Different Human Immunodeficiency Virus Type 1 Nef Functions during Progression to AIDS

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1

Cooperative Interactions of Simian Immunodeficiency Virus Nef, AP-2, and CD3-ζ Mediate the Selective Induction of T-Cell Receptor-CD3 Endocytosis

Human N-Myristoyltransferases Form Stable Complexes with Lentiviral Nef and Other Viral and Cellular Substrate Proteins

HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection

HIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells

CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain

Simian and Human Immunodeficiency Virus Nef Proteins Use Different Surfaces To Downregulate Class I Major Histocompatibility Complex Antigen Expression

HIV-1 Vpr protein directly loads helicase-like transcription factor (HLTF) onto the CRL4-DCAF1 E3 ubiquitin ligase

HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins

Mechanism of allosteric activation of SAMHD1 by dGTP

Comprehensive Analysis of Nef Functions Selected in Simian Immunodeficiency Virus-Infected Macaques

Disrupting Surfaces of Nef Required for Downregulation of CD4 and for Enhancement of Virion Infectivity Attenuates Simian Immunodeficiency Virus Replication In Vivo

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