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Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity

Journal of medicinal chemistry, 1994-01, Vol.37 (2), p.322-328

1994

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Novel 2-(Substituted phenyl)benzimidazole Derivatives with Potent Activity against IgE, Cytokines, and CD23 for the Treatment of Allergy and Asthma

Journal of medicinal chemistry, 2004-12, Vol.47 (26), p.6451-6454

2004

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Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors

Journal of medicinal chemistry, 1991-02, Vol.34 (2), p.518-525

1991

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The biochemistry and pharmacology of PD 116124 (8-amino-2'-nordeoxyguanosine), an inhibitor of purine nucleoside phosphorylase (PNP)

The Journal of pharmacology and experimental therapeutics, 1992-01, Vol.260 (1), p.319

1992

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Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one (CI-972)

Journal of medicinal chemistry, 1992-05, Vol.35 (9), p.1605-1609

1992

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Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogs

Journal of medicinal chemistry, 1992-04, Vol.35 (8), p.1451-1457

1992

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Discovery of Potent Cyclic GMP Phosphodiesterase Inhibitors. 2-Pyridyl- and 2-Imidazolylquinazolines Possessing Cyclic GMP Phosphodiesterase and Thromboxane Synthesis Inhibitory Activities

Journal of medicinal chemistry, 1995-09, Vol.38 (18), p.3547-3557

1995

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Comparative in vitro and in vivo activities of two 9-deazaguanine analog inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955

Biochemical pharmacology, 1992-09, Vol.44 (5), p.996-999

1992

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Activities of Two 9-Deazaguanine Analogue Inhibitors of Purine Nucleoside Phosphorylase, CI-972 and PD 141955, in Vitro and in Vivo

Annals of the New York Academy of Sciences, 1993-06, Vol.685 (1), p.248-251

1993

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Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase

Journal of medicinal chemistry, 1990-08, Vol.33 (8), p.2070

1990

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Hydroxylamine analogs of 2,6 di- t-butylphenols: Dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors

Bioorganic & medicinal chemistry, 1995-04, Vol.3 (4), p.403-410

1995

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Reduction of nitroalkenes to nitroalkanes with aqueous sodium borohydride

Journal of organic chemistry, 1967-12, Vol.32 (12), p.4134-4136

1967

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Preliminary report on 8-amino-9-(2-thienylmethyl)guanine (PD 119,229), a novel and potent purine nucleoside phosphorylase inhibitor

Agents and Actions, 1987-08, Vol.21 (3-4), p.272-274

1987

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8-Amino-9-substituted guanines: potent purine nucleoside phosphorylase (PNP) inhibitors

Agents and Actions, 1987-08, Vol.21 (3-4), p.253-256

1987

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Inhibitors of human purine nucleoside phosphorylase. Synthesis, purine nucleoside phosphorylase inhibition, and T-cell cytotoxicity of 2,5-diaminothiazolo[5,4-d]pyrimidin-7(6H)-one and 2,5-diaminothiazolo[4,5-d]pyrimidin-7(6H)-one. Two thio isosteres of 8-aminoguanine

Journal of medicinal chemistry, 1986-09, Vol.29 (9), p.1804-1806

1986

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Aza steroids. VII. 18-Nor-D-homo-8-aza steroids

Journal of organic chemistry, 1967-04, Vol.32 (4), p.1248-1250

1967

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Free-radical bromination of methyl abietate by N-bromosuccinimide and solvolysis of the products

Journal of organic chemistry, 1970-09, Vol.35 (9), p.3090-3093

1970

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Photochemical reactions of resin acids. Photochemically initiated addition of methanol to abietic acid

Journal of organic chemistry, 1969-02, Vol.34 (2), p.404-408

1969

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Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis

Biochemical pharmacology, 1983, Vol.32 (1), p.170-172

1983

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A small molecule compound (AVP-13358) in Phase I clinical development suppresses experimental allergy in animals via a distinctly Novel mechanism

Journal of allergy and clinical immunology, 2005-02, Vol.115 (2), p.S68-S68

2005

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Identification and development of a small molecule compound effective in suppressing early mediators of allergy

Journal of allergy and clinical immunology, 2003-02, Vol.111 (2), p.S88-S88

2003

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The synthesis of 7-aminobenzo[a]cycloalkano[f]quinolizinium perchlorates. An example of the addition of enamines to the nitrile function

Journal of organic chemistry, 1967-04, Vol.32 (4), p.1250-1251

1967

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Synthesis of 7-aminobenzo[a]cycloalkano[f]quino-lizinium perchlorates. An example of the addition of enamines to the nitrile function

Journal of organic chemistry, 1967-04, Vol.32 (4), p.1250-1251

1967

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A Convenient Method for the Preparation of 1,3-Cyclohexanedione1

Journal of organic chemistry, 1965-09, Vol.30 (9), p.3206-3207

1965

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Hydrogen and syngas production and purification technologies

1, 2010

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Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity

Novel 2-(Substituted phenyl)benzimidazole Derivatives with Potent Activity against IgE, Cytokines, and CD23 for the Treatment of Allergy and Asthma

Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors

The biochemistry and pharmacology of PD 116124 (8-amino-2'-nordeoxyguanosine), an inhibitor of purine nucleoside phosphorylase (PNP)

Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogs

Discovery of Potent Cyclic GMP Phosphodiesterase Inhibitors. 2-Pyridyl- and 2-Imidazolylquinazolines Possessing Cyclic GMP Phosphodiesterase and Thromboxane Synthesis Inhibitory Activities

Comparative in vitro and in vivo activities of two 9-deazaguanine analog inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955

Activities of Two 9-Deazaguanine Analogue Inhibitors of Purine Nucleoside Phosphorylase, CI-972 and PD 141955, in Vitro and in Vivo

Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase

Hydroxylamine analogs of 2,6 di- t-butylphenols: Dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors

Reduction of nitroalkenes to nitroalkanes with aqueous sodium borohydride

Preliminary report on 8-amino-9-(2-thienylmethyl)guanine (PD 119,229), a novel and potent purine nucleoside phosphorylase inhibitor

8-Amino-9-substituted guanines: potent purine nucleoside phosphorylase (PNP) inhibitors

Inhibitors of human purine nucleoside phosphorylase. Synthesis, purine nucleoside phosphorylase inhibition, and T-cell cytotoxicity of 2,5-diaminothiazolo[5,4-d]pyrimidin-7(6H)-one and 2,5-diaminothiazolo[4,5-d]pyrimidin-7(6H)-one. Two thio isosteres of 8-aminoguanine

Aza steroids. VII. 18-Nor-D-homo-8-aza steroids

Free-radical bromination of methyl abietate by N-bromosuccinimide and solvolysis of the products

Photochemical reactions of resin acids. Photochemically initiated addition of methanol to abietic acid

Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis

A small molecule compound (AVP-13358) in Phase I clinical development suppresses experimental allergy in animals via a distinctly Novel mechanism

Identification and development of a small molecule compound effective in suppressing early mediators of allergy

The synthesis of 7-aminobenzo[a]cycloalkano[f]quinolizinium perchlorates. An example of the addition of enamines to the nitrile function

Synthesis of 7-aminobenzo[a]cycloalkano[f]quino-lizinium perchlorates. An example of the addition of enamines to the nitrile function

A Convenient Method for the Preparation of 1,3-Cyclohexanedione1

Hydrogen and syngas production and purification technologies

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