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Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

Clinical pharmacology and therapeutics, 2014-02, Vol.95 (2), p.179-188

2014

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Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole

Oncogene, 2007-01, Vol.26 (2), p.258-268

2007

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Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1399-1423

2016

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Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice

Chemical research in toxicology, 1998-04, Vol.11 (4), p.252-259

1998

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Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group-An Industry Perspective

Drug metabolism and disposition, 2016-10, Vol.44 (10), p.1720-1730

2016

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The effect of troglitazone biliary excretion on metabolite distribution and cholestasis in transporter-deficient rats

Drug metabolism and disposition, 2001-12, Vol.29 (12), p.1561

2001

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Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes

Xenobiotica, 2000, Vol.30 (3), p.273-284

2000

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Metabolism and excretion studies in mouse after single and multiple oral doses of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin

Drug metabolism and disposition, 1998-08, Vol.26 (8), p.755

1998

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CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

Drug metabolism and disposition, 2002-07, Vol.30 (7), p.795-804

2002

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Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions

Current drug metabolism, 2006-05, Vol.7 (4), p.375-388

2006

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Characterization of Phase I and Phase II hepatic drug metabolism activities in a panel of human liver preparations

Chemico-biological interactions, 1999-04, Vol.118 (2), p.151-169

1999

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Leitbilder und Handlungsstrategien für die Raumentwicklung in Deutschland: Entwicklungs-, Umsetzungs- und Fortschreibungsprozess der Bund-Länder-Strategie für Städte und Regionen

Standort (Berlin, Germany), 2010-09, Vol.34 (3), p.80-87

2010

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Isolation and characterization of a novel quaternary ammonium-linked glucuronide of lamotrigine

Drug metabolism and disposition, 1991-01, Vol.19 (1), p.149

1991

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Characterization of the induction of rat microsomal cytochrome P450 by tacrine

Biochemical pharmacology, 1997-08, Vol.54 (3), p.425-427

1997

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Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens. Evidence for accumulation of tacrine in brain tissue

Drug metabolism and disposition, 1996-06, Vol.24 (6), p.628

1996

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Cytochrome P450 reaction-phenotyping: an industrial perspective

Expert opinion on drug metabolism & toxicology, 2007-10, Vol.3 (5), p.667-687

2007

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Endovenous thermal ablation of superficial truncal veins and compression therapy result in symptom relief in venous valve aplasia

Journal of vascular surgery cases and innovative techniques, 2023-06, Vol.9 (2), p.101113, Article 101113

2023

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Comparison of humans versus mobile phone-powered artificial intelligence for the diagnosis and management of pigmented skin cancer in secondary care: a multicentre, prospective, diagnostic, clinical trial

The Lancet. Digital health, 2023-10, Vol.5 (10), p.e679-e691

2023

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A quaternary ammonium glucuronide is the major metabolite of lamotrigine in guinea pigs. In vitro and in vivo studies

Drug metabolism and disposition, 1991-05, Vol.19 (3), p.630

1991

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Neue Leitbilder der Raumentwicklung. Ein Impuls zur Modernisierung der Raumordnung ?

Raumforschung und Raumordnung, 2006-11, Vol.64 (6), p.451-459

2006

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Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390 : A lead HIV protease inhibitor

Bioorganic & medicinal chemistry, 1999-12, Vol.7 (12), p.2775-2800

1999

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Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays

Journal of biomolecular screening, 2004-09, Vol.9 (6), p.533-540

2004

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Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition

Drug metabolism and disposition, 2003-04, Vol.31 (4), p.439-446

2003

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In vitro and in vivo disposition of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide (CI-976). Identification of a novel five-carbon cleavage metabolite in rats

Drug metabolism and disposition, 1997-01, Vol.25 (1), p.123

1997

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Use of cryopreserved transiently transfected cells in high-throughput pregnane X receptor transactivation assay

Journal of biomolecular screening, 2007-03, Vol.12 (2), p.248-254

2007

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Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole

Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective

Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice

Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group-An Industry Perspective

The effect of troglitazone biliary excretion on metabolite distribution and cholestasis in transporter-deficient rats

Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes

Metabolism and excretion studies in mouse after single and multiple oral doses of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions

Characterization of Phase I and Phase II hepatic drug metabolism activities in a panel of human liver preparations

Leitbilder und Handlungsstrategien für die Raumentwicklung in Deutschland: Entwicklungs-, Umsetzungs- und Fortschreibungsprozess der Bund-Länder-Strategie für Städte und Regionen

Isolation and characterization of a novel quaternary ammonium-linked glucuronide of lamotrigine

Characterization of the induction of rat microsomal cytochrome P450 by tacrine

Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens. Evidence for accumulation of tacrine in brain tissue

Cytochrome P450 reaction-phenotyping: an industrial perspective

Endovenous thermal ablation of superficial truncal veins and compression therapy result in symptom relief in venous valve aplasia

Comparison of humans versus mobile phone-powered artificial intelligence for the diagnosis and management of pigmented skin cancer in secondary care: a multicentre, prospective, diagnostic, clinical trial

A quaternary ammonium glucuronide is the major metabolite of lamotrigine in guinea pigs. In vitro and in vivo studies

Neue Leitbilder der Raumentwicklung. Ein Impuls zur Modernisierung der Raumordnung ?

Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390 : A lead HIV protease inhibitor

Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays

Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition

In vitro and in vivo disposition of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide (CI-976). Identification of a novel five-carbon cleavage metabolite in rats

Use of cryopreserved transiently transfected cells in high-throughput pregnane X receptor transactivation assay

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