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In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

Antimicrobial Agents and Chemotherapy, 2010-05, Vol.54 (5), p.1878-1887

2010

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TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage

Antimicrobial Agents and Chemotherapy, 2012-09, Vol.56 (9), p.4676-4684

2012

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Global Modulation of Cellular Transcription by Human Cytomegalovirus is Initiated by Viral Glycoprotein B

Proceedings of the National Academy of Sciences - PNAS, 2001-06, Vol.98 (13), p.7140-7145

2001

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Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors

Journal of Virology, 2007-07, Vol.81 (13), p.6909-6919

2007

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1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors

Antimicrobial Agents and Chemotherapy, 2008-12, Vol.52 (12), p.4420-4431

2008

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1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus

Journal of Virology, 2010-03, Vol.84 (6), p.2923-2934

2010

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Application of the trak-C™ HCV core assay for monitoring antiviral activity in HCV replication systems

Journal of virological methods, 2004-06, Vol.118 (1), p.23-31

2004

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Development of a novel influenza A antiviral assay

Journal of virological methods, 2002-08, Vol.105 (1), p.105-114

2002

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Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements

Journal of Virology, 1997-05, Vol.71 (5), p.3886-3894

1997

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TFIID is required for in vitro transcription of the human U6 gene by RNA polymerase III

The EMBO journal, 1991-07, Vol.10 (7), p.1853-1862

1991

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Cofractionation of the TATA-binding protein with the RNA polymerase III transcription factor TFIIIB

Nucleic acids research, 1992-11, Vol.20 (22), p.5889-5898

1992

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Common and unique transcription factor requirements of human U1 and U6 snRNA genes

The EMBO journal, 1993-09, Vol.12 (9), p.3573-3585

1993

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Complex requirements for RNA poIymerase III transcription of the Xenopus U6 promoter

Nucleic acids research, 1990-10, Vol.18 (19), p.5649-5657

1990

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Proximal sequence element factor binding and species specificity in vertebrate U6 snRNA promoters

Journal of molecular biology, 1992-02, Vol.223 (4), p.873-884

1992

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In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Antimicrobial Agents and Chemotherapy, 2009-04, Vol.53 (4), p.1377-1385

2009

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Antiviral Activity of TMC353121, a Respiratory Syncytial Virus (RSV) Fusion Inhibitor, in a Non-Human Primate Model

PloS one, 2015-05, Vol.10 (5), p.e0126959-e0126959

2015

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Tracking the Evolution of Multiple In Vitro Hepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing

Journal of Virology, 2010-11, Vol.84 (21), p.11124-11133

2010

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Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

Angewandte Chemie (International ed.), 2010-02, Vol.49 (9), p.1652-1655

2010

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Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4853-4858

2008

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Rapid HCV-RNA Decline With Once Daily TMC435: A Phase I Study in Healthy Volunteers and Hepatitis C Patients

Gastroenterology (New York, N.Y. 1943), 2010-03, Vol.138 (3), p.913-921

2010

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Efficacy of Re-treatment With TMC435 as Combination Therapy in Hepatitis C Virus–Infected Patients Following TMC435 Monotherapy

Gastroenterology (New York, N.Y. 1943), 2012-11, Vol.143 (5), p.1176-1178.e6

2012

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Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library

Antiviral research, 2017-11, Vol.147, p.149-158

2017

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Rapid viral response of once-daily TMC435 plus pegylated interferon/ribavirin in hepatitis C genotype-1 patients: a randomized trial

Antiviral therapy, 2011-01, Vol.16 (7), p.1021-1033

2011

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Synthesis and evaluation of novel HCV replication inhibitors

Molecular diversity, 2017-05, Vol.21 (2), p.475-481

2017

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2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase

Journal of medicinal chemistry, 2010-11, Vol.53 (22), p.8150-8160

2010

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In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage

Global Modulation of Cellular Transcription by Human Cytomegalovirus is Initiated by Viral Glycoprotein B

Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors

1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors

1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus

Application of the trak-C™ HCV core assay for monitoring antiviral activity in HCV replication systems

Development of a novel influenza A antiviral assay

Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements

TFIID is required for in vitro transcription of the human U6 gene by RNA polymerase III

Cofractionation of the TATA-binding protein with the RNA polymerase III transcription factor TFIIIB

Common and unique transcription factor requirements of human U1 and U6 snRNA genes

Complex requirements for RNA poIymerase III transcription of the Xenopus U6 promoter

Proximal sequence element factor binding and species specificity in vertebrate U6 snRNA promoters

In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Antiviral Activity of TMC353121, a Respiratory Syncytial Virus (RSV) Fusion Inhibitor, in a Non-Human Primate Model

Tracking the Evolution of Multiple In Vitro Hepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing

Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

Rapid HCV-RNA Decline With Once Daily TMC435: A Phase I Study in Healthy Volunteers and Hepatitis C Patients

Efficacy of Re-treatment With TMC435 as Combination Therapy in Hepatitis C Virus–Infected Patients Following TMC435 Monotherapy

Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library

Rapid viral response of once-daily TMC435 plus pegylated interferon/ribavirin in hepatitis C genotype-1 patients: a randomized trial

Synthesis and evaluation of novel HCV replication inhibitors

2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase

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