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Torcetrapib‐induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone

British journal of pharmacology, 2008-08, Vol.154 (7), p.1465-1473

2008

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

Cardiovascular research, 2003-04, Vol.58 (1), p.32-45

2003

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Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors

Journal of medicinal chemistry, 1992-03, Vol.35 (5), p.833-846

1992

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Comparison of electrocardiographic analysis for risk of QT interval prolongation using safety pharmacology and toxicological studies

Journal of pharmacological and toxicological methods, 2009-09, Vol.60 (2), p.107-116

2009

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Methods for assessing endothelin ETA-receptor antagonists in preclinical studies

Methods and Findings in Experimental and Clinical Pharmacology, 2002-07, Vol.24 (6), p.361-370

2002

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Comparison of Cardiovascular Responses to the Bradycardic Drugs, Alinidine, AQ-A 39, and Mixidine, in the Anesthetized Dog

Journal of cardiovascular pharmacology, 1984-07, Vol.6 (4), p.565-574

1984

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Pathophysiological Roles of Endothelin-1 in Dahl Salt-Sensitive Hypertension

Hypertension (Dallas, Tex. 1979), 1999-09, Vol.34 (3), p.514-519

1999

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L-368,899, a potent orally active oxytocin antagonist for potential use in preterm labor

Drug development research, 1993-11, Vol.30 (3), p.129-142

1993

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Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2919-2922

1991

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BRL 34915 (Cromakalim) Activates ATP-Sensitive K+ Current in Cardiac Muscle

Proceedings of the National Academy of Sciences - PNAS, 1988-11, Vol.85 (21), p.8360-8364

1988

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Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone. Commenary

British journal of pharmacology, 2008, Vol.154 (7)

2008

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Antithrombotic efficacy of recombinant tick anticoagulant peptide : a potent inhibitor of coagulation factor Xa in a primate model of arterial thrombosis

Circulation (New York, N.Y.), 1991-10, Vol.84 (4), p.1741-1748

1991

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In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist

The Journal of pharmacology and experimental therapeutics, 1992-07, Vol.262 (1), p.133

1992

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Responses to Amrinone in Isolated Cardiac Muscles from Cat, Rabbit, and Guinea Pig

Journal of cardiovascular pharmacology, 1984-03, Vol.6 (2), p.281-287

1984

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In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist

The Journal of pharmacology and experimental therapeutics, 1992-07, Vol.262 (1), p.139

1992

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Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts

Journal of molecular and cellular cardiology, 1989-08, Vol.21 (8), p.783-788

1989

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Characterization of recombinant tick anticoagulant peptide. A highly selective inhibitor of blood coagulation factor Xa

The Journal of biological chemistry, 1990-10, Vol.265 (29), p.17746-17752

1990

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Triazolinone Biphenylsulfonamides as Angiotensin II Receptor Antagonists with High Affinity for Both the AT1 and AT2 Subtypes

Journal of medicinal chemistry, 1994-12, Vol.37 (26), p.4464-4478

1994

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A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor

Journal of medicinal chemistry, 1993-10, Vol.36 (21), p.3207-3210

1993

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Cardiac angiotensin receptors: effects of selective angiotensin II receptor antagonists, DUP 753 and PD 121981, in rabbit heart

The Journal of pharmacology and experimental therapeutics, 1992-06, Vol.261 (3), p.931

1992

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The negative inotropic potency of compound D 600 in rat, guinea pig, and rabbit cardiac preparations

Canadian journal of physiology and pharmacology, 1980-12, Vol.58 (12), p.1406-1411

1980

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A highly potent, orally active imidazo-[4,5-b]pyridine biphenylacylsulfonamide (MK-996;L-159,282) : a new AT1-selective angiotensin II receptor antagonist

Journal of medicinal chemistry, 1994-11, Vol.37 (24), p.4068-4072

1994

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Inhibition of Na+/Ca+Exchange in Membrane Vesicle and Papillary Muscle Preparations from Guinea Pig Heart by Analogs of Amiloride

Proceedings of the National Academy of Sciences - PNAS, 1984-05, Vol.81 (10), p.3238-3242

1984

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Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes

Journal of medicinal chemistry, 1995-09, Vol.38 (19), p.3741-3758

1995

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Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates

Journal of medicinal chemistry, 1993-11, Vol.36 (23), p.3595-3605

1993

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Torcetrapib‐induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors

Comparison of electrocardiographic analysis for risk of QT interval prolongation using safety pharmacology and toxicological studies

Methods for assessing endothelin ETA-receptor antagonists in preclinical studies

Comparison of Cardiovascular Responses to the Bradycardic Drugs, Alinidine, AQ-A 39, and Mixidine, in the Anesthetized Dog

Pathophysiological Roles of Endothelin-1 in Dahl Salt-Sensitive Hypertension

L-368,899, a potent orally active oxytocin antagonist for potential use in preterm labor

Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists

BRL 34915 (Cromakalim) Activates ATP-Sensitive K+ Current in Cardiac Muscle

Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone. Commenary

Antithrombotic efficacy of recombinant tick anticoagulant peptide : a potent inhibitor of coagulation factor Xa in a primate model of arterial thrombosis

In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist

Responses to Amrinone in Isolated Cardiac Muscles from Cat, Rabbit, and Guinea Pig

In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist

Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts

Characterization of recombinant tick anticoagulant peptide. A highly selective inhibitor of blood coagulation factor Xa

Triazolinone Biphenylsulfonamides as Angiotensin II Receptor Antagonists with High Affinity for Both the AT1 and AT2 Subtypes

A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor

Cardiac angiotensin receptors: effects of selective angiotensin II receptor antagonists, DUP 753 and PD 121981, in rabbit heart

The negative inotropic potency of compound D 600 in rat, guinea pig, and rabbit cardiac preparations

A highly potent, orally active imidazo-[4,5-b]pyridine biphenylacylsulfonamide (MK-996;L-159,282) : a new AT1-selective angiotensin II receptor antagonist

Inhibition of Na+/Ca+Exchange in Membrane Vesicle and Papillary Muscle Preparations from Guinea Pig Heart by Analogs of Amiloride

Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes

Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates

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