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Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis

Nature chemical biology, 2020-01, Vol.16 (1), p.87-94

2020

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Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta

Bioinformatics (Oxford, England), 2017-09, Vol.33 (17), p.2765-2767

2017

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Computational protein design enables a novel one-carbon assimilation pathway

Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (12), p.3704-3709

2015

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Increased Diels-Alderase activity through backbone remodeling guided by Foldit players

Nature biotechnology, 2012-02, Vol.30 (2), p.190-192

2012

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Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

Science (American Association for the Advancement of Science), 2010-07, Vol.329 (5989), p.309-313

2010

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Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset

PLoS computational biology, 2024-07, Vol.20 (7), p.e1012248

2024

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Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform

Nature communications, 2022-08, Vol.13 (1), p.5021-5021, Article 5021

2022

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Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase

Proceedings of the National Academy of Sciences - PNAS, 2014-06, Vol.111 (22), p.8013-8018

2014

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Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway

Nature communications, 2015-11, Vol.6 (1), p.10005-10005, Article 10005

2015

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A new benchmark illustrates that integration of geometric constraints inferred from enzyme reaction chemistry can increase enzyme active site modeling accuracy

PloS one, 2019-04, Vol.14 (4), p.e0214126-e0214126

2019

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Orthogonal glycolytic pathway enables directed evolution of noncanonical cofactor oxidase

Nature communications, 2022-11, Vol.13 (1), p.7282-14, Article 7282

2022

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Discovery, Design, and Structural Characterization of Alkane-Producing Enzymes across the Ferritin-like Superfamily

Biochemistry (Easton), 2020-10, Vol.59 (40), p.3834-3843

2020

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Predicting Productive Binding Modes for Substrates and Carbocation Intermediates in Terpene SynthasesBornyl Diphosphate Synthase As a Representative Case

ACS catalysis, 2018-04, Vol.8 (4), p.3322-3330

2018

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High-throughput mutagenesis reveals unique structural features of human ADAR1

Nature communications, 2020-10, Vol.11 (1), p.5130-13, Article 5130

2020

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Thermal stability and kinetic constants for 129 variants of a family 1 glycoside hydrolase reveal that enzyme activity and stability can be separately designed

PloS one, 2017-05, Vol.12 (5), p.e0176255-e0176255

2017

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Evaluating Protein Engineering Thermostability Prediction Tools Using an Independently Generated Dataset

ACS omega, 2020-03, Vol.5 (12), p.6487-6493

2020

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Kinetic Characterization of 100 Glycoside Hydrolase Mutants Enables the Discovery of Structural Features Correlated with Kinetic Constants

PloS one, 2016-01, Vol.11 (1), p.e0147596

2016

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Preliminary Techno-Economic Assessment of Animal Cell-Based Meat

Foods, 2020-12, Vol.10 (1), p.3

2020

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The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair

Journal of the American Chemical Society, 2018-10, Vol.140 (41), p.13260-13271

2018

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Discovery of a natural cyan blue: A unique food-sourced anthocyanin could replace synthetic brilliant blue

Science advances, 2021-04, Vol.7 (15)

2021

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Computational enzyme design: Transitioning from catalytic proteins to enzymes

Current opinion in structural biology, 2014-08, Vol.27, p.87-94

2014

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Acid-active proteases to optimize dietary protein digestibility: a step towards sustainable nutrition

Frontiers in nutrition (Lausanne), 2024-02, Vol.11, p.1291685

2024

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Awakening the natural capability of psicose production in Escherichia coli

NPJ science of food, 2023-10, Vol.7 (1), p.54-54, Article 54

2023

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Brewers’ Spent Grain: An Unprecedented Opportunity to Develop Sustainable Plant-Based Nutrition Ingredients Addressing Global Malnutrition Challenges

Journal of agricultural and food chemistry, 2023-07, Vol.71 (28), p.10543-10564

2023

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Molecular annotation of food – Towards personalized diet and precision health

Trends in food science & technology, 2019-09, Vol.91, p.675-680

2019

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Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis

Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta

Computational protein design enables a novel one-carbon assimilation pathway

Increased Diels-Alderase activity through backbone remodeling guided by Foldit players

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset

Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform

Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase

Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway

A new benchmark illustrates that integration of geometric constraints inferred from enzyme reaction chemistry can increase enzyme active site modeling accuracy

Orthogonal glycolytic pathway enables directed evolution of noncanonical cofactor oxidase

Discovery, Design, and Structural Characterization of Alkane-Producing Enzymes across the Ferritin-like Superfamily

Predicting Productive Binding Modes for Substrates and Carbocation Intermediates in Terpene SynthasesBornyl Diphosphate Synthase As a Representative Case

High-throughput mutagenesis reveals unique structural features of human ADAR1

Thermal stability and kinetic constants for 129 variants of a family 1 glycoside hydrolase reveal that enzyme activity and stability can be separately designed

Evaluating Protein Engineering Thermostability Prediction Tools Using an Independently Generated Dataset

Kinetic Characterization of 100 Glycoside Hydrolase Mutants Enables the Discovery of Structural Features Correlated with Kinetic Constants

Preliminary Techno-Economic Assessment of Animal Cell-Based Meat

The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair

Discovery of a natural cyan blue: A unique food-sourced anthocyanin could replace synthetic brilliant blue

Computational enzyme design: Transitioning from catalytic proteins to enzymes

Acid-active proteases to optimize dietary protein digestibility: a step towards sustainable nutrition

Awakening the natural capability of psicose production in Escherichia coli

Brewers’ Spent Grain: An Unprecedented Opportunity to Develop Sustainable Plant-Based Nutrition Ingredients Addressing Global Malnutrition Challenges

Molecular annotation of food – Towards personalized diet and precision health

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