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PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML

Leukemia, 2008-09, Vol.22 (9), p.1698-1706

2008

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Phosphospecific proteolysis for mapping sites of protein phosphorylation

Nature biotechnology, 2003-09, Vol.21 (9), p.1047-1054

2003

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Sole BCR-ABL Inhibition Is Insufficient to Eliminate All Myeloproliferative Disorder Cell Populations

Proceedings of the National Academy of Sciences - PNAS, 2004-12, Vol.101 (50), p.17456-17461

2004

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Chemically targeting the PI3K family

Biochemical Society transactions, 2007-04, Vol.35 (Pt 2), p.245

2007

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Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors

Oncogene, 2014-03, Vol.33 (12), p.1590-1600

2014

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Antigen-induced B-cell death and elimination during germinal-centre immune responses

Nature (London), 1995-05, Vol.375 (6529), p.334-338

1995

Volltextzugriff (PDF)

Targets of the cyclin-dependent kinase Cdk1

Nature, 2003-10, Vol.425 (6960), p.859-864

2003

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A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src

Bioorganic & medicinal chemistry, 1998-08, Vol.6 (8), p.1219-1226

1998

Volltextzugriff (PDF)

A Chemical-Genetic Approach to Studying Neurotrophin Signaling

Neuron (Cambridge, Mass.), 2005-04, Vol.46 (1), p.13-21

2005

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Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2

Genes & development, 2003-06, Vol.17 (12), p.1524-1539

2003

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The F Box Protein Dsg1/Mdm30 Is a Transcriptional Coactivator that Stimulates Gal4 Turnover and Cotranscriptional mRNA Processing

Cell, 2005-03, Vol.120 (6), p.887-899

2005

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A chemical switch for inhibitor-sensitive alleles of any protein kinase

Nature (London), 2000-09, Vol.407 (6802), p.395-401

2000

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Two Cyclin-Dependent Kinases Promote RNA Polymerase II Transcription and Formation of the Scaffold Complex

Molecular and Cellular Biology, 2004-02, Vol.24 (4), p.1721-1735

2004

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Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells

The Journal of experimental medicine, 1994-02, Vol.179 (2), p.425-438

1994

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ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation

Nature cell biology, 2001-03, Vol.3 (3), p.325-330

2001

Volltextzugriff (PDF)

Magic bullets for protein kinases

Trends in Cell Biology, 2001-04, Vol.11 (4), p.167-172

2001

Volltextzugriff (PDF)

Engineering Unnatural Nucleotide Specificity for Rous Sarcoma Virus Tyrosine Kinase to Uniquely Label its Direct Substrates

Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (8), p.3565-3570

1997

Volltextzugriff (PDF)

The emerging power of chemical genetics

Current Opinion in Cell Biology, 2002-04, Vol.14 (2), p.155-159

2002

Volltextzugriff (PDF)

Inducible Protein Knockout Reveals Temporal Requirement of CaMKII Reactivation for Memory Consolidation in the Brain

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (7), p.4287-4292

2003

Volltextzugriff (PDF)

Chemical Genetics: Where Genetics and Pharmacology Meet

Cell, 2007-02, Vol.128 (3), p.425-430

2007

Volltextzugriff (PDF)

Chemical genetic approaches for the elucidation of signaling pathways

Current Opinion in Chemical Biology, 2001-08, Vol.5 (4), p.360-367

2001

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Src−Abl Tyrosine Kinase Chimeras: Replacement of the Adenine Binding Pocket of c-Abl with v-Src To Swap Nucleotide and Inhibitor Specificities

Biochemistry (Easton), 2000-11, Vol.39 (47), p.14400-14408

2000

Volltextzugriff (PDF)

Chemical Inhibition of the Pho85 Cyclin-Dependent Kinase Reveals a Role in the Environmental Stress Response

Proceedings of the National Academy of Sciences - PNAS, 2001-10, Vol.98 (22), p.12578-12583

2001

Volltextzugriff (PDF)

Dynamic Phosphoregulation of the Cortical Actin Cytoskeleton and Endocytic Machinery Revealed by Real-Time Chemical Genetic Analysis

The Journal of cell biology, 2003-09, Vol.162 (5), p.765-772

2003

Volltextzugriff (PDF)

Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p

Nature cell biology, 2000-10, Vol.2 (10), p.677-685

2000

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PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML

Phosphospecific proteolysis for mapping sites of protein phosphorylation

Sole BCR-ABL Inhibition Is Insufficient to Eliminate All Myeloproliferative Disorder Cell Populations

Chemically targeting the PI3K family

Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors

Antigen-induced B-cell death and elimination during germinal-centre immune responses

Targets of the cyclin-dependent kinase Cdk1

A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src

A Chemical-Genetic Approach to Studying Neurotrophin Signaling

Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2

The F Box Protein Dsg1/Mdm30 Is a Transcriptional Coactivator that Stimulates Gal4 Turnover and Cotranscriptional mRNA Processing

A chemical switch for inhibitor-sensitive alleles of any protein kinase

Two Cyclin-Dependent Kinases Promote RNA Polymerase II Transcription and Formation of the Scaffold Complex

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells

ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation

Magic bullets for protein kinases

Engineering Unnatural Nucleotide Specificity for Rous Sarcoma Virus Tyrosine Kinase to Uniquely Label its Direct Substrates

The emerging power of chemical genetics

Inducible Protein Knockout Reveals Temporal Requirement of CaMKII Reactivation for Memory Consolidation in the Brain

Chemical Genetics: Where Genetics and Pharmacology Meet

Chemical genetic approaches for the elucidation of signaling pathways

Src−Abl Tyrosine Kinase Chimeras: Replacement of the Adenine Binding Pocket of c-Abl with v-Src To Swap Nucleotide and Inhibitor Specificities

Chemical Inhibition of the Pho85 Cyclin-Dependent Kinase Reveals a Role in the Environmental Stress Response

Dynamic Phosphoregulation of the Cortical Actin Cytoskeleton and Endocytic Machinery Revealed by Real-Time Chemical Genetic Analysis

Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p

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