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Observing a DNA Polymerase Choose Right from Wrong

Cell, 2013-07, Vol.154 (1), p.157-168

2013

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Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

Nature (London), 2015-01, Vol.517 (7536), p.635-639

2015

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Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints

Nature communications, 2022-06, Vol.13 (1), p.3193-12, Article 3193

2022

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Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton

The Journal of biological chemistry, 2010-12, Vol.285 (52), p.40479-40488

2010

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Time-lapse crystallography snapshots of a double-strand break repair polymerase in action

Nature communications, 2017-08, Vol.8 (1), p.253-11, Article 253

2017

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Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

Nature communications, 2021-08, Vol.12 (1), p.5055-11, Article 5055

2021

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Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

Nature communications, 2021-04, Vol.12 (1), p.2059-12, Article 2059

2021

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Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse

Proceedings of the National Academy of Sciences - PNAS, 2015-09, Vol.112 (38), p.E5228-E5236

2015

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Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction

Nature chemical biology, 2017-10, Vol.13 (10), p.1074

2017

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A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

Nucleic acids research, 2019-04, Vol.47 (6), p.3197

2019

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Magnesium-Induced Assembly of a Complete DNA Polymerase Catalytic Complex

Structure (London), 2006-04, Vol.14 (4), p.757-766

2006

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Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (1), p.113-118

2012

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Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β

The Journal of biological chemistry, 2019-05, Vol.294 (18), p.7194-7201

2019

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DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context

The Journal of biological chemistry, 2020-01, Vol.295 (2), p.529-538

2020

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Substrate-induced DNA Polymerase β Activation

The Journal of biological chemistry, 2014-11, Vol.289 (45), p.31411-31422

2014

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Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation

Molecular cell, 2008-05, Vol.30 (3), p.315-324

2008

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Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction

Journal of the American Chemical Society, 2013-05, Vol.135 (21), p.8078-8088

2013

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Coordination of Steps in Single-nucleotide Base Excision Repair Mediated by Apurinic/Apyrimidinic Endonuclease 1 and DNA Polymerase β

The Journal of biological chemistry, 2007-05, Vol.282 (18), p.13532-13541

2007

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Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate

ACS omega, 2020-06, Vol.5 (25), p.15317-15324

2020

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DNA Polymerase λ Mediates a Back-up Base Excision Repair Activity in Extracts of Mouse Embryonic Fibroblasts

The Journal of biological chemistry, 2005-05, Vol.280 (18), p.18469-18475

2005

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Substrate Rescue of DNA Polymerase β Containing a Catastrophic L22P Mutation

Biochemistry (Easton), 2014-04, Vol.53 (14), p.2413-2422

2014

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DNA Polymerase β and Flap Endonuclease 1 Enzymatic Specificities Sustain DNA Synthesis for Long Patch Base Excision Repair

The Journal of biological chemistry, 2005-02, Vol.280 (5), p.3665-3674

2005

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Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity

The Journal of biological chemistry, 2002-12, Vol.277 (49), p.47393-47398

2002

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Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (36), p.15693-15698

2010

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Metal-induced DNA translocation leads to DNA polymerase conformational activation

Nucleic acids research, 2012-04, Vol.40 (7), p.2974

2012

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Observing a DNA Polymerase Choose Right from Wrong

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints

Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action

Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse

Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction

A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

Magnesium-Induced Assembly of a Complete DNA Polymerase Catalytic Complex

Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion

Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β

DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context

Substrate-induced DNA Polymerase β Activation

Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation

Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction

Coordination of Steps in Single-nucleotide Base Excision Repair Mediated by Apurinic/Apyrimidinic Endonuclease 1 and DNA Polymerase β

Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate

DNA Polymerase λ Mediates a Back-up Base Excision Repair Activity in Extracts of Mouse Embryonic Fibroblasts

Substrate Rescue of DNA Polymerase β Containing a Catastrophic L22P Mutation

DNA Polymerase β and Flap Endonuclease 1 Enzymatic Specificities Sustain DNA Synthesis for Long Patch Base Excision Repair

Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity

Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid

Metal-induced DNA translocation leads to DNA polymerase conformational activation

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